File:Tectum signaling model 01.jpg

Tectum Development Signaling Model

Model for a possible cooperation of Meis2, Pax3, Pax7 and Otx2 during tectal development.

• MHB - mid-hindbrain boundary

Red lines indicate negative regulation, green arrows positive regulation. Dashed lines indicate hypothetical direct regulation of the Meis2 promoter/enhancer by different Pax3 concentrations. Solid lines indicate indirect regulation of Meis2 expression via Pax3/7 mediated induction of Fgf8 as previously reported:

1. Regulation of Meis2 expression in response to Ras-MAPK signaling levels
2. Induction of Fgf8 by Pax3 and Pax7
3. Existence of Meis2-Otx2 containing protein complexes in the tectal anlage

Links: tectum

Reference

Agoston Z, Li N, Haslinger A, Wizenmann A & Schulte D. (2012). Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. BMC Dev. Biol. , 12, 10. PMID: 22390724 DOI.

Copyright

© 2012 Agoston et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Agoston et al. BMC Developmental Biology 2012 12:10 doi:10.1186/1471-213X-12-10

1471-213X-12-10-6.jpg

Cite this page: Hill, M.A. (2024, April 28) Embryology Tectum signaling model 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Tectum_signaling_model_01.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G