File:Schwann and axon interactions.jpg

Model of interactions between myelinating Schwann cells and axons

• Showing proteins that localize to the node, paranode, juxtaparanode, and internode.
• Schwann cell, blue; axon, yellow. PN, paranode; JPN, juxtaparanode.

Analysis of the Necl proteins provides important new insight into molecular complexes along the internode (Maurel et al., 2007; Spiegel et al., 2007), which had not been as well defined as for the other domains.

The polarity protein Par-3 colocalizes with Necl-4 in the adaxonal region of the Schwann cell (Chan et al., 2006), and it is possible that these proteins interact via PDZ and PDZ-binding motifs (red). The Necl proteins can also interact with FERM domain proteins via the FERM-binding domain (blue). Necls are also present at the Schmidt-Lanterman incisures (inset). Necl-2 is not depicted but localizes to the axon–Schwann cell interface and to the incisures.

Reference

<pubmed>17724116</pubmed>| PMC2064536 | JCB

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This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

The figure was adapted from Voas et al. (2007). http://jcb.rupress.org/content/178/5/721/F1.large.jpg

Cite this page: Hill, M.A. (2024, April 27) Embryology Schwann and axon interactions.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Schwann_and_axon_interactions.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G