File:Rat neural cadherin 02.jpg

Expression of cad7 and cad20 and transcription factors in the early neural plate

Images shown in A, D, E, O and B, C, F-N are taken from the anterior and dorsal sides, respectively. A-I: Cad7 mRNA is expressed in the forebrain region (A). The anterior border of cad7 expression in the hindbrain is consistent with that of Krox20 in the r3 (green arrowhead in B and C). At E10.5, cad20 is expressed in the forebrain region and the expression region overlaps with that of Six3 (D, E). Cad20 expression is absent in the anterior margin of the neural plate (arrow in E), which is different from Six3 expression (arrow in D). Blue arrowheads in D and G indicate the expression boundary between Six3 and Irx3. The boundary between cad20- and Irx3-domains demarcates the position of the presumptive zona limitans intrathalamica (ZLI) (arrowhead in F, G and H). I-O: At E10.5, the posterior border of cad7 expression corresponds to the midbrain/hindbrain boundary (MHB) as indicated by Gbx2 (black arrowhead in M). The border of cad20 expression is not consistent with the posterior border of Otx2 (black arrowhead in N), the expression is detected in the r2 region expressing Gbx2. The posterior border of cad20 is detected anterior to forebrain/midbrain boundary (arrows in O).

pos, pre otic sulcus; fb, forebrain; mb, midbrain; hb, hindbrain, anr, anterior neural ridge; MHB, midbrain/hindbrain boundary.

Scale bars: 200 μm in A-H

Reference

<pubmed>18801203</pubmed>| PMC2564927 | BMC Dev Biol.

© 2008 Takahashi and Osumi; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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