File:Primitive streak cell migration.jpg

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Chicken Primitive Streak Cell Migration

DiI labelling in HH8 embryos reveals behaviour and trajectories of cells from the primitive streak.

(A, B, C) Long-term time-lapse imaging of embryos labelled in Hensen's node (A), the anterior (B) or posterior primitive streak (C) with DiI. Embryos were imaged for 20 hours and still pictures are shown at intervals of 2.5 hours.


(D, E, F) Transverse sections of embryos labelled in Hensen's node (D), anterior (E) or posterior streak (F).


(G) Summary of cell fates. Red represents Hensen's node and notochord (nc), green represents anterior primitive streak cells and paraxial mesoderm (pm) and blue represents posterior primitive streak cells and lateral plate mesoderm (lpm). n, node; nc, notochord; pm, paraxial mesoderm; s, somites. In (A) asterisks indicate the position of the node which regresses during axis extension. In (A, B, C) arrows show the most recently formed somite and arrowheads in (B, C) indicate the position of the most anterior DiI-labelled cells.

"Distinct behaviours of paraxial and lateral mesoderm precursors are regulated by the opposing actions of Wnt5a and Wnt3a as they leave the primitive streak in neurula stage embryos. Our data suggests that Wnt5a acts via prickle to cause migration of cells from the posterior streak. In the anterior streak, this is antagonised by Wnt3a to generate non-migratory medial mesoderm."


Links: Gastrulation | Chicken Development

Reference

Sweetman D, Wagstaff L, Cooper O, Weijer C & Münsterberg A. (2008). The migration of paraxial and lateral plate mesoderm cells emerging from the late primitive streak is controlled by different Wnt signals. BMC Dev. Biol. , 8, 63. PMID: 18541012 DOI.


Copyright

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BMC Dev Biol. 2008; 8: 63. Published online 2008 June 9. doi: 10.1186/1471-213X-8-63. Copyright © 2008 Sweetman et al; licensee BioMed Central Ltd.

Original file name: 1471-213X-8-63-1.jpg


Cite this page: Hill, M.A. (2024, April 25) Embryology Primitive streak cell migration.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Primitive_streak_cell_migration.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current20:38, 3 August 2009Thumbnail for version as of 20:38, 3 August 2009600 × 420 (92 KB)S8600021 (talk | contribs)DiI labelling in HH8 embryos reveals behaviour and trajectories of cells from the primitive streak. (A, B, C) Long-term time-lapse imaging of embryos labelled in Hensen's node (A), the anterior (B) or posterior primitive streak (C) with DiI. Embryos wer

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