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Cyst formation at the level of the cell, nephron, and kidney

  • Defects in the genes encoding PC1 or PC2 lead to aberrant gene transcription, cell proliferation, and ion secretion, which in turn result in the formation of fluid-filled cysts.
  • As cysts balloon out from individual nephrons, their collective effect leads to the displacement of the normal renal parenchyma and the formation of a cyst-filled kidney with reduced functional capacity.

Reference

<pubmed>21079243</pubmed>| JCB


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current21:42, 6 March 2012Thumbnail for version as of 21:42, 6 March 20121,280 × 486 (120 KB)Z8600021 (talk | contribs)==Cyst formation at the level of the cell, nephron, and kidney== * Defects in the genes encoding PC1 or PC2 lead to aberrant gene transcription, cell proliferation, and ion secretion, which in turn result in the formation of fluid-filled cysts. * As cys

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