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Endocrine Pancreas - Beta Cell Secretion
Pancreatic Endocrine Tissue Comprises 1%, or Less, of the Pancreas and Is Organized as Clusters of Cells Dispersed throughout the Exocrine Pancreas. Glucose-dependent insulin secretion from β cells, by analogy to excitation–contraction coupling in muscle, is referred to as stimulus-secretion coupling.
- Glucose stimulation elicits depolarisation of the cell membrane and electrical activity in β cells.
- Opens calcium ion (Ca 2+) channels in the membrane that respond to changes in voltage—voltage-dependent calcium channels (VDCCs)
- Allow Ca 2+ entry and action potential firing.
- Ca 2+ acts on the exocytotic machinery to stimulate fusion of insulin-containing vesicles with the plasma membrane.
- Vesicle secretion into the bloodstream.
(text modified from original reference)
Reference
<pubmed>16464129</pubmed>| PLoS Biol.
Citation: MacDonald PE, Rorsman P (2006) Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells. PLoS Biol 4(2): e49. doi:10.1371/journal.pbio.0040049
Published: February 14, 2006
Copyright: © 2006 MacDonald and Rorsman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:50, 5 October 2009 | | 1,000 × 347 (51 KB) | S8600021 (talk | contribs) | http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.0040049 Citation: MacDonald PE, Rorsman P (2006) Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells. PLoS Biol 4(2): e49. doi:10.1371/journal.pbio.0 |
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