File:Notch structure cartoon.jpg

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Notch Structure cartoon

The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).
  • gray ovals - N-terminal 36 EGF-like repeats
  • orange ovals - (LNR) lin-12 Notch
  • pink ovals - EGF repeats
  • gray rectangles - ankyrin (ANK) domain
  • gray star - C-terminal PEST sequence
  • red arrows - cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).


Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors

Reference

<pubmed>19255248</pubmed>

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Cite this page: Hill, M.A. (2024, May 19) Embryology Notch structure cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Notch_structure_cartoon.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current20:49, 4 February 2015Thumbnail for version as of 20:49, 4 February 20151,093 × 227 (35 KB)Z8600021 (talk | contribs)==Notch Structure cartoon== The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an...

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