File:Neutrophil 01.jpg
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Neutrophil
- neutrophil granulocyte or polymorphonuclear leukocyte (PMN).
- most common leukocyte in blood smears, about 60% neutrophils (50% - 70%)
- nucleus is divided into 3-5 lobes connected by thin strands of chromatin.
- lobe number increases with cell age (old cells up to 7 lobes).
- contain two types of granules stain only weakly if they are at all visible ("neutral").
Granules
- primary granules (A granules)
- contain lysosomal enzymes and are probably primary lysosomes.
- larger (0.4 µm) than the typical primary lysosome.
- secondary granules (B granules)
- the specific granules of the neutrophils
- contain enzymes with strong bactericidal actions
- these granules stain only weakly if they are at all visible ("neutral").
Functions
- neutrophils locate and eliminate pathogens (bacterial and fungal) and regulate immunity and inflammation.
- ability to release neutrophil extracellular traps.
- Newly identified roles
- proposed to participate in protection against intracellular pathogens (viruses and mycobacteria).
- involved in adaptive immune response.
- mediate alternative pathway of systemic anaphylaxis
- participate in allergic skin reactions.
- improper activation may also lead to tissue damage during an autoimmune or exaggerated inflammatory reaction
- Blood Histology: Blood Development | Blood Cell Number Table | Lymphocyte 1 | Lymphocyte 2 | Lymphocyte 3 | Lymphocyte 4 | Monocyte 1 | Monocyte 2 | Monocyte 3 | Monocyte 4 | Neutrophils 1 | Neutrophil 2 | Neutrophil 3 | Neutrophil 4 | Eosinophil 1 | Eosinophil 2 | labeled Neutrophil and Eosinophil | unlabeled - Neutrophil and Eosinophil | Basophil 1 | Basophil 2 | Basophil 3 | Platelet 1 | Platelet 2 | Reticulocyte | Megakaryocyte | Movie | Bone Marrow Histology | Category:Blood
Blood Cells |
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Adult human blood cell numbers shown in the table below is for reference purposes.
Blood Cell NumbersThe adult ranges of cells / 1 litre (l), total blood volume is about 4.7 to 5 litres. Blood Development | Blood Histology Red Blood Cells
Leukocytes (white blood cells)
Granulocytes
Non-Granulocytes
Lymphocytes
Platelets
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Links: Histology | Histology Stains | Blue Histology images copyright Lutz Slomianka 1998-2009. The literary and artistic works on the original Blue Histology website may be reproduced, adapted, published and distributed for non-commercial purposes. See also the page Histology Stains.
Cite this page: Hill, M.A. (2024, May 8) Embryology Neutrophil 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Neutrophil_01.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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