File:Neural tube SHH patterning cartoon.jpg

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Sonic Hedgehog acts in a graded manner to pattern the ventral neural tube

A A morphogen can pattern a developing tissue. A secreted signal (blue) is produced from a localized source (S) and spreads through the tissue to establish a gradient. Cells respond to different concentrations of the signal by regulating different sets of genes (red, orange and yellow). This induces distinct cell fates (A, B and C) at different distances from S (adapted from the French Flag Model in Wolpert, 1969).

B Shh protein (brown) is produced from the notochord (n) and floor plate at the ventral midline of the neural tube. Shh spreads dorsally establishing a gradient that controls the generation of distinct neuronal subtypes (interneurons (V0–V3) and motor neurons (MN)). In vitro, different concentrations of Shh are sufficient to induce the distinct neuronal subtypes. The concentration of Shh necessary to induce a specific subtype corresponds to its position of generation in vivo.


SHH Links: Sonic hedgehog | Shh receptors | Category:Sonic Hedgehog | Neural System Development

Reference

Briscoe J. (2009). Making a grade: Sonic Hedgehog signalling and the control of neural cell fate. EMBO J. , 28, 457-65. PMID: 19197245 DOI.

Copyright

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation without specific permission.


EMBO J. 2009 March 4; 28(5): 457–465. Published online 2009 February 5. doi: 10.1038/emboj.2009.12. Copyright © 2009, European Molecular Biology Organization

Original file name: Emboj200912f1.jpg


Cite this page: Hill, M.A. (2024, April 13) Embryology Neural tube SHH patterning cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Neural_tube_SHH_patterning_cartoon.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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