File:Mouse sex determination genes 01.jpg: Difference between revisions
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==Sex Determination in Mice== | ==Sex Determination in Mice== | ||
[[:Category:Mouse E10.5|E10.5]] - bipotential gonads arise from the genital ridges. | [[:Category:Mouse E10.5|'''E10.5''']] - bipotential gonads arise from the genital ridges. | ||
[[:Category:Mouse E10.5|E10.5]] - somatic cells of XY genital ridges, Sry expression (dark blue line at lower part of figure) starts | [[:Category:Mouse E10.5|'''E10.5''']] - somatic cells of XY genital ridges, Sry expression (dark blue line at lower part of figure) starts | ||
[[:Category:Mouse E11.5|E11.5]] - Sry expression reaches a peak | [[:Category:Mouse E11.5|'''E11.5''']] - Sry expression reaches a peak | ||
[[:Category:Mouse E12.5|E12.5]] - Sry wanes then a few hours later, Sox9 expression (light blue line at the lower part of the figure) is upregulated to induce di erentiation of Sertoli cells. | [[:Category:Mouse E12.5|'''E12.5''']] - Sry wanes then a few hours later, Sox9 expression (light blue line at the lower part of the figure) is upregulated to induce di erentiation of Sertoli cells. | ||
[[:Category:Mouse E11.5|E11.5]] to [[Mouse E12.5|E12.5]] - Sox9 expression peaks and continues to be expressed postnatally and is supported by several positive-feedback loops (including fibroblast growth factor 9 (FGF9), prostaglandin D2 (PGD2) and SOX9 itself ), and SOX9 subsequently activates many male-specific genes, including the gene encoding anti-Müllerian hormone (Amh). | [[:Category:Mouse E11.5|'''E11.5''']] to [[:Category:Mouse E12.5|'''E12.5''']] - Sox9 expression peaks and continues to be expressed postnatally and is supported by several positive-feedback loops (including fibroblast growth factor 9 (FGF9), prostaglandin D2 (PGD2) and SOX9 itself ), and SOX9 subsequently activates many male-specific genes, including the gene encoding anti-Müllerian hormone (Amh). | ||
[[:Category:Mouse E12.5|E12.5]] - morphological di erences between testis and ovary are evident. In the absence of SRY, genes such as Wnt4, Rspo1 and Foxl2 are expressed in a female-specific manner and induce ovarian development, as characterized by the expression of follistatin and many other ovary-specific genes. FOXL2, forkhead box L2; SOX9, SRY box containing gene 9; SRY, sex-determining region on the chromosome Y. | [[:Category:Mouse E12.5|'''E12.5''']] - morphological di erences between testis and ovary are evident. In the absence of SRY, genes such as Wnt4, Rspo1 and Foxl2 are expressed in a female-specific manner and induce ovarian development, as characterized by the expression of follistatin and many other ovary-specific genes. FOXL2, forkhead box L2; SOX9, SRY box containing gene 9; SRY, sex-determining region on the chromosome Y. | ||
:'''Links:''' {{Ovary}} | {{Testis}} | {{Mouse}} | {{Wnt}} | |||
===Reference=== | ===Reference=== | ||
| Line 18: | Line 21: | ||
{{#pmid:21062860}} | {{#pmid:21062860}} | ||
====Copyright==== | |||
© BioMed Central Ltd. 2012 | |||
Text modified from Figure legend. | |||
{{Footer}} | {{Footer}} | ||
[[Category:Mouse]] | [[Category:Mouse]][[Category:Genital]][[Category:Sry]] | ||
[[Category:Ovary]][[Category:Testis]][[Category:Wnt]] | |||
Latest revision as of 06:57, 12 December 2018
Sex Determination in Mice
E10.5 - bipotential gonads arise from the genital ridges.
E10.5 - somatic cells of XY genital ridges, Sry expression (dark blue line at lower part of figure) starts
E11.5 - Sry expression reaches a peak
E12.5 - Sry wanes then a few hours later, Sox9 expression (light blue line at the lower part of the figure) is upregulated to induce di erentiation of Sertoli cells.
E11.5 to E12.5 - Sox9 expression peaks and continues to be expressed postnatally and is supported by several positive-feedback loops (including fibroblast growth factor 9 (FGF9), prostaglandin D2 (PGD2) and SOX9 itself ), and SOX9 subsequently activates many male-specific genes, including the gene encoding anti-Müllerian hormone (Amh).
E12.5 - morphological di erences between testis and ovary are evident. In the absence of SRY, genes such as Wnt4, Rspo1 and Foxl2 are expressed in a female-specific manner and induce ovarian development, as characterized by the expression of follistatin and many other ovary-specific genes. FOXL2, forkhead box L2; SOX9, SRY box containing gene 9; SRY, sex-determining region on the chromosome Y.
Reference
de Lau WB, Snel B & Clevers HC. (2012). The R-spondin protein family. Genome Biol. , 13, 242. PMID: 22439850 DOI.
Kashimada K & Koopman P. (2010). Sry: the master switch in mammalian sex determination. Development , 137, 3921-30. PMID: 21062860 DOI.
Copyright
© BioMed Central Ltd. 2012
Text modified from Figure legend.
Cite this page: Hill, M.A. (2024, May 5) Embryology Mouse sex determination genes 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_sex_determination_genes_01.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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