File:Mouse sex determination genes 01.jpg: Difference between revisions

Latest revision as of 06:57, 12 December 2018

Sex Determination in Mice

E10.5 - bipotential gonads arise from the genital ridges.

E10.5 - somatic cells of XY genital ridges, Sry expression (dark blue line at lower part of figure) starts

E11.5 - Sry expression reaches a peak

E12.5 - Sry wanes then a few hours later, Sox9 expression (light blue line at the lower part of the figure) is upregulated to induce di erentiation of Sertoli cells.

E11.5 to E12.5 - Sox9 expression peaks and continues to be expressed postnatally and is supported by several positive-feedback loops (including fibroblast growth factor 9 (FGF9), prostaglandin D2 (PGD2) and SOX9 itself ), and SOX9 subsequently activates many male-specific genes, including the gene encoding anti-Müllerian hormone (Amh).

E12.5 - morphological di erences between testis and ovary are evident. In the absence of SRY, genes such as Wnt4, Rspo1 and Foxl2 are expressed in a female-specific manner and induce ovarian development, as characterized by the expression of follistatin and many other ovary-specific genes. FOXL2, forkhead box L2; SOX9, SRY box containing gene 9; SRY, sex-determining region on the chromosome Y.

Links: ovary | testis | mouse | Wnt

Reference

de Lau WB, Snel B & Clevers HC. (2012). The R-spondin protein family. Genome Biol. , 13, 242. PMID: 22439850 DOI.

Kashimada K & Koopman P. (2010). Sry: the master switch in mammalian sex determination. Development , 137, 3921-30. PMID: 21062860 DOI.

Copyright

Text modified from Figure legend.

Cite this page: Hill, M.A. (2024, May 5) Embryology Mouse sex determination genes 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_sex_determination_genes_01.jpg

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	16:51, 20 February 2018		1,280 × 923 (73 KB)	Z8600021 (talk \| contribs)	resize and crop
	16:46, 20 February 2018		2,061 × 1,862 (286 KB)	Z8600021 (talk \| contribs)	===Reference=== 22439850

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@@ Line 1: / Line 1: @@
-==Overview of sex determination in mice==
+==Sex Determination in Mice==
-During mouse embryogenesis, bipotential gonads arise from the genital ridges by 10.5
+[[:Category:Mouse E10.5|'''E10.5''']] - bipotential gonads arise from the genital ridges.
-days post-conception (dpc).
-In somatic cells of XY genital ridges, Sry expression (dark blue line at lower part of figure) starts at 10.5 dpc, reaches a peak at 11.5 dpc and then wanes by 12.5 dpc. A few hours later, Sox9 expression (light blue line at the lower part of the figure) is upregulated to induce di erentiation of Sertoli cells. Sox9 expression peaks at 11.5 to 12.5 dpc, continues to be expressed postnatally and is supported by several positive-feedback loops (including  broblast growth factor 9 (FGF9), prostaglandin D2 (PGD2) and SOX9 itself ), and SOX9 subsequently activates many male-speci c genes, including the gene encoding anti-Müllerian hormone (Amh). At 12.5 dpc, morphological di erences between testis and ovary are evident. In the absence of SRY, genes such as Wnt4, Rspo1 and Foxl2 are expressed in a female-speci c manner and induce ovarian development, as characterized by the expression of follistatin and many other ovary-speci c genes. FOXL2, forkhead box L2; SOX9, SRY box containing gene 9; SRY, sex-determining region on the chromosome Y.
+[[:Category:Mouse E10.5|'''E10.5''']] - somatic cells of XY genital ridges, Sry expression (dark blue line at lower part of figure) starts
+[[:Category:Mouse E11.5|'''E11.5''']] - Sry expression reaches a peak
+[[:Category:Mouse E12.5|'''E12.5''']] - Sry wanes then a few hours later, Sox9 expression (light blue line at the lower part of the figure) is upregulated to induce di erentiation of Sertoli cells.
+[[:Category:Mouse E11.5|'''E11.5''']] to [[:Category:Mouse E12.5|'''E12.5''']] - Sox9 expression peaks and continues to be expressed postnatally and is supported by several positive-feedback loops (including  fibroblast growth factor 9 (FGF9), prostaglandin D2 (PGD2) and SOX9 itself ), and SOX9 subsequently activates many male-specific genes, including the gene encoding anti-Müllerian hormone (Amh).
+[[:Category:Mouse E12.5|'''E12.5''']] - morphological di erences between testis and ovary are evident. In the absence of SRY, genes such as Wnt4, Rspo1 and Foxl2 are expressed in a female-specific manner and induce ovarian development, as characterized by the expression of follistatin and many other ovary-specific genes. FOXL2, forkhead box L2; SOX9, SRY box containing gene 9; SRY, sex-determining region on the chromosome Y.
+:'''Links:''' {{Ovary}} | {{Testis}} | {{Mouse}} | {{Wnt}}
 ===Reference===
@@ Line 10: / Line 21: @@
 {{#pmid:21062860}}
+====Copyright====
+© BioMed Central Ltd. 2012
+Text modified from Figure legend.
+{{Footer}}
+[[Category:Mouse]][[Category:Genital]][[Category:Sry]]
+[[Category:Ovary]][[Category:Testis]][[Category:Wnt]]