Difference between revisions of "File:Mouse ruga pattern.jpg"

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==Mouse Palate (adult and E16==
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==Mouse Palate Adult and E16==
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Palatal rugae are the transvere ridges forming on the secondary palate which are also sequentially added during development as the palate grows. Their number and arrangement on the hard palate of mammals is species specific. Along with the teeth and the tongue these ridges function in the process of mastication.
  
Mouse adult ruga pattern and its visualization in the fetus by in situ hybridization against Shh gene.  
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Figure shows the mouse ruga pattern in the adult and the fetus shown by in situ hybridization against [[Developmental Signals - Sonic hedgehog|Sonic hedgehog]] gene.  
  
'''(A)''' The roof of the oral cavity of an adult mouse showing the palatal ridges (rugae palatinae) on the hard palate.  
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* '''A''' - The roof of the oral cavity of an adult mouse showing the palatal ridges (rugae palatinae) on the hard palate.
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* '''B''' - Mouse rugae pattern with numbering used in this study. Note that ruga 7b was called 8b in other studies  (Peterkova et al. 1987 PMID 3624420; Charles et al. 2007 PMID 18028050).
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* '''C''' - In ED16.0 fetus, Shh gene expression pattern (as seen by whole-mount in situ hybridization) prefigures the adult ruga pattern.
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* '''D''' - Sagittal section through the same embryo as in C, showing Shh expression in the epithelium at the tip of rugae (see magnification in the low left corner). The absence of Shh signal in the rugae 1–4 can be explained by its discontinuity in the anterior rugae at this stage (see C).
  
'''(B)''' Mouse rugae pattern with numbering used in this study. Note that ruga 7b was called 8b in other studies (Peterkova et al. 1987; Charles et al. 2007).
 
  
'''(C)''' In ED16.0 fetus, Shh gene expression pattern (as seen by whole-mount in situ hybridization) prefigures the adult ruga pattern.
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:'''Links:''' [[:File:Mouse ruga pattern.jpg|Adult and E16 Palatal Rugae]] | [[:File:Mouse palatal rugae pattern E16.jpg|E16 Palatal Rugae]] [[Mouse Development]] | [[Palate Development]] | [[Developmental Signals - Sonic hedgehog|Sonic hedgehog]]
  
'''(D)''' Sagittal section through the same embryo as in C, showing Shh expression in the epithelium at the tip of rugae (see magnification in the low left corner). The absence of Shh signal in the rugae 1–4 can be explained by its discontinuity in the anterior rugae at this stage (see C).
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:From the paper - "We showed that palatal rugae are sequentially added to the growing palate, in an interposition process that appears to be dependent on activation-inhibition mechanisms and reveals a new developmental boundary in the growing palate. Further studies on rugae may help to shed light on both the development and evolution of structures arranged in regular patterns. Moreover, rugae will undoubtedly be powerful tools to further study the anteroposterior regionalization of the growing palate."
  
:'''Links:''' [[Mouse Development]] | [[Palate Development]] | [[Sonic hedgehog]]
 
  
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===Reference===
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<pubmed>19087265</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637861 PMC2637861] | [http://www.biomedcentral.com/1471-213X/8/116 BMC Dev Biol.]
  
:"We showed that palatal rugae are sequentially added to the growing palate, in an interposition process that appears to be dependent on activation-inhibition mechanisms and reveals a new developmental boundary in the growing palate. Further studies on rugae may help to shed light on both the development and evolution of structures arranged in regular patterns. Moreover, rugae will undoubtedly be powerful tools to further study the anteroposterior regionalization of the growing palate."
 
  
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====Copyright====
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© 2008 Pantalacci et al; licensee BioMed Central Ltd.
  
  
Original File Name: 1471-213X-8-116-1.jpg
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 
 
==Reference==
 
<pubmed>19087265</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637861 PMC2637861]
 
BMC Dev Biol. 2008; 8: 116.
 
 
 
  
 
Published online 2008 December 16. doi: 10.1186/1471-213X-8-116.
 
Published online 2008 December 16. doi: 10.1186/1471-213X-8-116.
  
Copyright © 2008 Pantalacci et al; licensee BioMed Central Ltd.
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Original File Name: Figure 1. 1471-213X-8-116-1.jpg http://www.biomedcentral.com/1471-213X/8/116/figure/F1
  
  
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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{{Footer}}
 
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[[Category:Mouse]] [[Category:Sonic Hedgehog]] [[Category:Palate]] [[Category:Mouse E16]]
[[Category:Mouse]] [[Category:Shh]] [[Category:Palate]]
 

Latest revision as of 13:09, 5 February 2016

Mouse Palate Adult and E16

Palatal rugae are the transvere ridges forming on the secondary palate which are also sequentially added during development as the palate grows. Their number and arrangement on the hard palate of mammals is species specific. Along with the teeth and the tongue these ridges function in the process of mastication.

Figure shows the mouse ruga pattern in the adult and the fetus shown by in situ hybridization against Sonic hedgehog gene.

  • A - The roof of the oral cavity of an adult mouse showing the palatal ridges (rugae palatinae) on the hard palate.
  • B - Mouse rugae pattern with numbering used in this study. Note that ruga 7b was called 8b in other studies (Peterkova et al. 1987 PMID 3624420; Charles et al. 2007 PMID 18028050).
  • C - In ED16.0 fetus, Shh gene expression pattern (as seen by whole-mount in situ hybridization) prefigures the adult ruga pattern.
  • D - Sagittal section through the same embryo as in C, showing Shh expression in the epithelium at the tip of rugae (see magnification in the low left corner). The absence of Shh signal in the rugae 1–4 can be explained by its discontinuity in the anterior rugae at this stage (see C).


Links: Adult and E16 Palatal Rugae | E16 Palatal Rugae Mouse Development | Palate Development | Sonic hedgehog
From the paper - "We showed that palatal rugae are sequentially added to the growing palate, in an interposition process that appears to be dependent on activation-inhibition mechanisms and reveals a new developmental boundary in the growing palate. Further studies on rugae may help to shed light on both the development and evolution of structures arranged in regular patterns. Moreover, rugae will undoubtedly be powerful tools to further study the anteroposterior regionalization of the growing palate."


Reference

<pubmed>19087265</pubmed>| PMC2637861 | BMC Dev Biol.


Copyright

© 2008 Pantalacci et al; licensee BioMed Central Ltd.


This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published online 2008 December 16. doi: 10.1186/1471-213X-8-116.

Original File Name: Figure 1. 1471-213X-8-116-1.jpg http://www.biomedcentral.com/1471-213X/8/116/figure/F1



Cite this page: Hill, M.A. (2021, April 14) Embryology Mouse ruga pattern.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_ruga_pattern.jpg

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© Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current02:15, 29 March 2010Thumbnail for version as of 02:15, 29 March 2010600 × 1,059 (118 KB)S8600021 (talk | contribs)Mouse adult ruga pattern and its visualization in the fetus by in situ hybridization against Shh gene. (A) The roof of the oral cavity of an adult mouse showing the palatal ridges (rugae palatinae) on the hard palate. (B) Mouse rugae pattern with numb