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Neural crest (NC)-derived cells contribute to ocular development.  
Neural crest (NC)-derived cells contribute to ocular development.  


(a) Toluidine blue staining of an adult eye. The boxed areas correspond to b and c
* '''a''' Toluidine blue staining of an adult eye. The boxed areas correspond to b and c
* '''b''' A detailed view of the corneal assembly, including outer epithelium, stroma, and inner endothelium
* '''c''' The chamber angle at the irido-corneal transition which includes the trabecular meshwork (tm).
* '''d-j''' In vivo fate mapping of NC-derived, β-galactosidase (βGal)-expressing cells (blue)
* '''d''' The NC origin of corneal keratocytes (arrows) and of corneal endothelium (arrowhead).
* '''e''' Structures of the chamber angle, including the trabecular meshwork are seen to be NC-derived.
* '''f''' At E10, the optic cup is surrounded by NC-derived cells expressing βGal.
* '''g-i''' The majority of the cells in the periocular mesenchyme (arrows), which forms the anterior eye segment, are of NC origin, as assessed from E11.5 to E13.5.
* '''j''' The primary vitreous at E13.5 (arrowheads) shows a strong NC contribution.


(b) a detailed view of the corneal assembly, including outer epithelium, stroma, and inner endothelium


(c) the chamber angle at the irido-corneal transition which includes the trabecular meshwork (tm).


(d-j) In vivo fate mapping of NC-derived, β-galactosidase (βGal)-expressing cells (blue)
{{Mouse eye neural crest links}}
 
(d) the NC origin of corneal keratocytes (arrows) and of corneal endothelium (arrowhead).
 
(e) Structures of the chamber angle, including the trabecular meshwork are seen to be NC-derived.
 
(f) At E10, the optic cup is surrounded by NC-derived cells expressing βGal.
 
(g-i) The majority of the cells in the periocular mesenchyme (arrows), which forms the anterior eye segment, are of NC origin, as assessed from E11.5 to E13.5.
 
(j) The primary vitreous at E13.5 (arrowheads) shows a strong NC contribution.
 
 
Jbiol29-1.jpg


===Reference===
===Reference===
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<pubmed>16403239</pubmed>| [http://jbiol.com/content/4/3/11 J Biol.]
<pubmed>16403239</pubmed>| [http://jbiol.com/content/4/3/11 J Biol.]


Ittner et al. Journal of Biology 2005 4:11  doi:10.1186/jbiol29
 
====Copyright====


© 2005 Ittner et al.; licensee BioMed Central Ltd.
© 2005 Ittner et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


[[Category:Mouse]] [[Category:Neural Crest]] [[Category:Vision]]  
Ittner et al. Journal of Biology 2005 4:11  doi:10.1186/jbiol29 Original file name: Jbiol29-1.jpg
 
{{Footer}}
[[Category:Mouse]] [[Category:Neural Crest]] [[Category:Vision]] [[Category:Cornea]]
[[Category:Mouse E10]] [[Category:Mouse E11.5]] [[Category:Mouse E12.5]] [[Category:Mouse E13.5]]
[[Category:Mouse E10]] [[Category:Mouse E11.5]] [[Category:Mouse E12.5]] [[Category:Mouse E13.5]]

Latest revision as of 20:07, 3 August 2016

Mouse Eye Neural Crest

Neural crest (NC)-derived cells contribute to ocular development.

  • a Toluidine blue staining of an adult eye. The boxed areas correspond to b and c
  • b A detailed view of the corneal assembly, including outer epithelium, stroma, and inner endothelium
  • c The chamber angle at the irido-corneal transition which includes the trabecular meshwork (tm).
  • d-j In vivo fate mapping of NC-derived, β-galactosidase (βGal)-expressing cells (blue)
  • d The NC origin of corneal keratocytes (arrows) and of corneal endothelium (arrowhead).
  • e Structures of the chamber angle, including the trabecular meshwork are seen to be NC-derived.
  • f At E10, the optic cup is surrounded by NC-derived cells expressing βGal.
  • g-i The majority of the cells in the periocular mesenchyme (arrows), which forms the anterior eye segment, are of NC origin, as assessed from E11.5 to E13.5.
  • j The primary vitreous at E13.5 (arrowheads) shows a strong NC contribution.


Links: Image - Mouse eye neural crest | Image - cornea and anterior chamber | Image - cornea | Image - Mouse eye TGF-beta model | Vision - Cornea Development | Vision Development | Neural Crest | Head Development

Reference

<pubmed>16403239</pubmed>| J Biol.


Copyright

© 2005 Ittner et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Ittner et al. Journal of Biology 2005 4:11 doi:10.1186/jbiol29 Original file name: Jbiol29-1.jpg


Cite this page: Hill, M.A. (2024, May 6) Embryology Mouse eye neural crest.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_eye_neural_crest.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current18:25, 30 August 2011Thumbnail for version as of 18:25, 30 August 20111,086 × 1,509 (483 KB)S8600021 (talk | contribs)
18:20, 30 August 2011Thumbnail for version as of 18:20, 30 August 2011600 × 840 (158 KB)S8600021 (talk | contribs)==Mouse Eye Neural Crest== Neural crest (NC)-derived cells contribute to ocular development. (a) Toluidine blue staining of an adult eye. The boxed areas correspond to b and c (b) a detailed view of the corneal assembly, including outer epithelium, st