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Mouse Eye TGF-beta Model

Summary of the TGFβ-dependent development of anterior and posterior ocular structures.

a Neural crest-derived cells (NC, blue) contribute to structures of the anterior eye segment and the primary vitreous (PV).

TGFβ signaling is involved in the formation of the ciliary body (CB) and the trabecular meshwork (TM), and in control of PV growth.
Moreover, normal PV development and/or TGFβ signaling are important for correct retinal patterning.

b In the cornea, prospective stromal keratocytes and endothelial cells are of neural crest origin.

Here, TGFβ signaling is needed for the expression of the transcription factors Foxc1 and Pitx2 and for normal differentiation of NC-derived cells into collagen-synthesizing stromal keratocytes.
Moreover, in forming corneal endothelial cells (and in the TM), expression of Foxc1 and cell survival requires TGFβ signalling.

Reference

<pubmed>16403239</pubmed>| J Biol.

Copyright

© 2005 Ittner et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Ittner et al. Journal of Biology 2005 4:11 doi:10.1186/jbiol29

Original file name: Figure 9. http://jbiol.com/content/4/3/11/figure/F9

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current	18:32, 30 August 2011		1,000 × 519 (88 KB)	S8600021 (talk \| contribs)	==Mouse eye TGF-beta model== Summary of the TGFβ-dependent development of anterior and posterior ocular structures. (a) NC-derived cells (blue) contribute to structures of the anterior eye segment and the primary vitreous (PV). TGFβ signaling is invo

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 Summary of the TGFβ-dependent development of anterior and posterior ocular structures.
+{|
-'''a''' Neural crest-derived cells (NC, blue) contribute to structures of the anterior eye segment and the primary vitreous (PV).
+| valign=top|'''a''' Neural crest-derived cells (NC, blue) contribute to structures of the anterior eye segment and the primary vitreous (PV).
 * TGFβ signaling is involved in the formation of the ciliary body (CB) and the trabecular meshwork (TM), and in control of PV growth.
 * Moreover, normal PV development and/or TGFβ signaling are important for correct retinal patterning.
+| valign=top|'''b''' In the cornea, prospective stromal keratocytes and endothelial cells are of neural crest origin.
-'''b''' In the cornea, prospective stromal keratocytes and endothelial cells are of neural crest origin.
 * Here, TGFβ signaling is needed for the expression of the transcription factors Foxc1 and Pitx2 and for normal differentiation of NC-derived cells into collagen-synthesizing stromal keratocytes.
 * Moreover, in forming corneal endothelial cells (and in the TM), expression of Foxc1 and cell survival requires TGFβ signalling.
+|}