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Summary of the TGFβ-dependent development of anterior and posterior ocular structures. | Summary of the TGFβ-dependent development of anterior and posterior ocular structures. | ||
''' | '''a''' Neural crest-derived cells (NC, blue) contribute to structures of the anterior eye segment and the primary vitreous (PV). | ||
* TGFβ signaling is involved in the formation of the ciliary body (CB) and the trabecular meshwork (TM), and in control of PV growth. | * TGFβ signaling is involved in the formation of the ciliary body (CB) and the trabecular meshwork (TM), and in control of PV growth. | ||
* Moreover, normal PV development and/or TGFβ signaling are important for correct retinal patterning. | * Moreover, normal PV development and/or TGFβ signaling are important for correct retinal patterning. | ||
''' | '''b''' In the cornea, prospective stromal keratocytes and endothelial cells are of neural crest origin. | ||
* Here, TGFβ signaling is needed for the expression of the transcription factors Foxc1 and Pitx2 and for normal differentiation of NC-derived cells into collagen-synthesizing stromal keratocytes. | * Here, TGFβ signaling is needed for the expression of the transcription factors Foxc1 and Pitx2 and for normal differentiation of NC-derived cells into collagen-synthesizing stromal keratocytes. | ||
* Moreover, in forming corneal endothelial cells (and in the TM), expression of Foxc1 and cell survival requires TGFβ signalling. | * Moreover, in forming corneal endothelial cells (and in the TM), expression of Foxc1 and cell survival requires TGFβ signalling. | ||
:'''Links:''' [[:File:Mouse eye neural crest.jpg|Image - Mouse eye neural crest]] | [[:File:Mouse_eye_TGF-beta_model.jpg|Image - Mouse eye TGF-beta model]] | [[Sensory - Vision Development|Vision Development]] | [[Neural Crest Development]] | [[Head Development]] | :'''Links:''' [[:File:Mouse eye neural crest.jpg|Image - Mouse eye neural crest]] | [[:File:Mouse_eye_TGF-beta_model.jpg|Image - Mouse eye TGF-beta model]] [[Developmental_Signals_-_TGF-beta|TGF-beta]] | [[Vision_-_Cornea_Development|Cornea Development]] | [[Sensory - Vision Development|Vision Development]] | [[Neural Crest Development]] | [[Head Development]] | ||
===Reference=== | ===Reference=== | ||
<pubmed>16403239</pubmed>| [http://jbiol.com/content/4/3/11 J Biol.] | <pubmed>16403239</pubmed>| [http://jbiol.com/content/4/3/11 J Biol.] | ||
====Copyright==== | |||
© 2005 Ittner et al.; licensee BioMed Central Ltd. | © 2005 Ittner et al.; licensee BioMed Central Ltd. | ||
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||
Ittner et al. Journal of Biology 2005 4:11 doi:10.1186/jbiol29 | |||
Original file name: Figure 9. http://jbiol.com/content/4/3/11/figure/F9 | |||
[[Category:Mouse]] [[Category:Neural Crest]] [[Category:Vision]] [[Category:Cartoon]] | [[Category:Mouse]] [[Category:Neural Crest]] [[Category:Vision]] [[Category:Cartoon]] | ||
Revision as of 14:08, 30 August 2014
Mouse Eye TGF-beta Model
Summary of the TGFβ-dependent development of anterior and posterior ocular structures.
a Neural crest-derived cells (NC, blue) contribute to structures of the anterior eye segment and the primary vitreous (PV).
- TGFβ signaling is involved in the formation of the ciliary body (CB) and the trabecular meshwork (TM), and in control of PV growth.
- Moreover, normal PV development and/or TGFβ signaling are important for correct retinal patterning.
b In the cornea, prospective stromal keratocytes and endothelial cells are of neural crest origin.
- Here, TGFβ signaling is needed for the expression of the transcription factors Foxc1 and Pitx2 and for normal differentiation of NC-derived cells into collagen-synthesizing stromal keratocytes.
- Moreover, in forming corneal endothelial cells (and in the TM), expression of Foxc1 and cell survival requires TGFβ signalling.
- Links: Image - Mouse eye neural crest | Image - Mouse eye TGF-beta model TGF-beta | Cornea Development | Vision Development | Neural Crest Development | Head Development
Reference
<pubmed>16403239</pubmed>| J Biol.
Copyright
© 2005 Ittner et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ittner et al. Journal of Biology 2005 4:11 doi:10.1186/jbiol29
Original file name: Figure 9. http://jbiol.com/content/4/3/11/figure/F9
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