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Magnetic resonance microscopy (MRM) enables concurrent visualization of the brain and face of GD17 mouse fetuses.
==Mouse Brain E17 Magnetic Resonance Microscopy==
Forebrain regions, pituitary, and cerebellum were manually segmented from transverse 39 µm MRM sections (A). 3D brain reconstructions were generated by overlaying manually segmented regions with whole-brain masks (B). Reduced opacity of the left cortex and diencephalon allows visualization of the left ventricle, hippocampus, third ventricle, and pituitary. From the same MRM scans, 3D head reconstructions were created, allowing concurrent visualization of the face and brain in situ (C–D). The size of a GD17 mouse fetus can be appreciated when shown in scale with a U.S. penny (E).
 
Magnetic resonance microscopy (MRM) enables concurrent visualization of the brain and face of GD17 mouse foetuses.
 
* '''A''' - Forebrain regions, pituitary, and cerebellum were manually segmented from transverse 39 µm MRM sections.
* '''B''' - 3D brain reconstructions were generated by overlaying manually segmented regions with whole-brain masks.  
* '''C,D''' - Reduced opacity of the left cortex and diencephalon allows visualization of the left ventricle, hippocampus, third ventricle, and pituitary. From the same MRM scans, 3D head reconstructions were created, allowing concurrent visualization of the face and brain in situ.  
* '''E''' - The size of a GD17 mouse fetus can be appreciated when shown in scale with a U.S. penny.
 
 
 
:'''Links:''' [[Neural System Development]] | [[Magnetic Resonance Imaging]]





Revision as of 18:07, 27 August 2014

Mouse Brain E17 Magnetic Resonance Microscopy

Magnetic resonance microscopy (MRM) enables concurrent visualization of the brain and face of GD17 mouse foetuses.

  • A - Forebrain regions, pituitary, and cerebellum were manually segmented from transverse 39 µm MRM sections.
  • B - 3D brain reconstructions were generated by overlaying manually segmented regions with whole-brain masks.
  • C,D - Reduced opacity of the left cortex and diencephalon allows visualization of the left ventricle, hippocampus, third ventricle, and pituitary. From the same MRM scans, 3D head reconstructions were created, allowing concurrent visualization of the face and brain in situ.
  • E - The size of a GD17 mouse fetus can be appreciated when shown in scale with a U.S. penny.


Links: Neural System Development | Magnetic Resonance Imaging


Reference

<pubmed>25047453</pubmed>| PLoS One.


Copyright

© 2014 Lipinski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Figure 1. doi:10.1371/journal.pone.0102603.g001 Adjusted in size and labelling.

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