File:Molecular endocrine pancreas cells 01.jpg: Difference between revisions
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Model placing gastrin cells in the transcriptional hierarchy of endocrine cells in the pancreas. | Model placing gastrin cells in the transcriptional hierarchy of endocrine cells in the pancreas. | ||
Pancreatic G cells | {| | ||
| Four main endocrine adult cell types: | |||
# alpha cells secreting glucagon | |||
# beta cells secreting insulin | |||
# delta cells secreting somatostatin | |||
# PP cells secreting pancreatic polypeptide. | |||
| valign=top|Pancreatic G cells | |||
* similar to alpha cells in that it is dependent on Arx. | * similar to alpha cells in that it is dependent on Arx. | ||
* similar to epsilon cells in that both gastrin and ghrelin are frequently co-expressed with glucagon in the embryonic pancreas. | * similar to epsilon cells in that both gastrin and ghrelin are frequently co-expressed with glucagon in the embryonic pancreas. | ||
|} | |||
:'''Links:''' [[Endocrine - Pancreas Development|Endocrine ancreas]] | [[Developmental_Signals_-_Pax|Pax]] | [[Molecular Development]] | |||
{| | {| | ||
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|- | |- | ||
| valign=top| | | valign=top| | ||
* '''Pdx1''' - Pancreas/Duodenum Homeobox Protein 1 [http://omim.org/entry/600733 OMIM 600733] | |||
** transcription (transactivator) factor binds the TAAT element in the promoter region of target genes, mainly those involved in pancreas development. | |||
* '''Ngn3''' - Neurogenin3 [http://omim.org/entry/604882 OMIM 604882] | * '''Ngn3''' - Neurogenin3 [http://omim.org/entry/604882 OMIM 604882] | ||
** basic helix-loop-helix transcription factor involved in the determination of neural precursor cells in the neuroectoderm. | ** basic helix-loop-helix transcription factor involved in the determination of neural precursor cells in the neuroectoderm. | ||
* '''NeuroD1''' - Neurogenic Differentiation 1 [http://omim.org/entry/601724 OMIM 601724] | * '''NeuroD1''' - Neurogenic Differentiation 1 [http://omim.org/entry/601724 OMIM 601724] | ||
** a basic helix-loop-helix (bHLH) protein that acts as a transcription factors involved in determining cell type during development. | ** a basic helix-loop-helix (bHLH) protein that acts as a transcription factors involved in determining cell type during development. | ||
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* '''Pax4''' - Paired Box Gene 4 [http://omim.org/entry/167413 OMIM 167413] | * '''Pax4''' - Paired Box Gene 4 [http://omim.org/entry/167413 OMIM 167413] | ||
** transcription factor containing a paired box domain. | ** transcription factor containing a paired box domain. | ||
* '''Pax6''' [http://omim.org/entry/607108 OMIM 607108] | * '''Pax6''' Paired Box Gene 6 [http://omim.org/entry/607108 OMIM 607108] | ||
** transcription factor containing a paired box domain. | ** transcription factor containing a paired box domain. | ||
* '''Nkx2.2''' - NK2 Homeobox 2 [http://omim.org/entry/604612 OMIM 604612] | |||
** homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain. | |||
* '''Nkx6.1''' - NK2 Homeobox 6.1 [http://omim.org/entry/602563 OMIM 602563] | |||
** homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain. | |||
** required for beta cells development and is completely conserved between rat, mouse, and human. | |||
|} | |} | ||
{{Pax family collapsetable}} | |||
===References=== | ===References=== | ||
{{#pmid:23940571}} | |||
====Copyright==== | ====Copyright==== | ||
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Journal.pone.0070397.g007.jpg | Journal.pone.0070397.g007.jpg | ||
{{Footer}} | |||
[[Category:Pancreas]][[Category:Endocrine]][[Category:Molecular]][[Category:Hox]][[Category:Pax]] | [[Category:Pancreas]][[Category:Endocrine]][[Category:Molecular]][[Category:Hox]][[Category:Pax]] |
Latest revision as of 17:36, 6 April 2018
Molecular Development of Endocrine Pancreas Cells
Model placing gastrin cells in the transcriptional hierarchy of endocrine cells in the pancreas.
Four main endocrine adult cell types:
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Pancreatic G cells
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- Links: Endocrine ancreas | Pax | Molecular Development
Factor Information | |
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Human PAX Family | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, McCracken K, Wells JM, Heller RS, Dor Y & Glaser B. (2013). Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS ONE , 8, e70397. PMID: 23940571 DOI.
Copyright
© 2013 Suissa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal.pone.0070397.g007.jpg
Cite this page: Hill, M.A. (2024, May 6) Embryology Molecular endocrine pancreas cells 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Molecular_endocrine_pancreas_cells_01.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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