File:Model for Sprouty4 and FGF in mesoderm segmentation.jpg

Model for Sprouty4 and FGF in mesoderm segmentation

A Putative Model for the role of Sprouty4 as a mediator that links the segmentation clock to the gradient of FGF signaling. In the PSM, FGF signaling establishes a posterior-to-anterior gradient, which is involved in the positioning of presumptive somite boundaries. Cyclic Sprouty4, which is controlled by the Notch segmentation clock, the mechanism of which includes negative feedback loop of Hes7, may inhibit the FGF signaling possibly around the anterior border of the FGF signaling positive area, where the FGF signaling is close to its threshold. Thus, the FGF signaling may be periodically inhibited by Sprouty4, by which temporal periodicity of Notch segmentation clock may be translated to spatial periodicity of the array of somites. S, somite; PS, presumptive somite.

Original file name: Figure 6 Pone.0005603.g006.jpg

Reference

<pubmed>19440349</pubmed>| PMC2680047

PLoS ONE. 2009; 4(5): e5603. Published online 2009 May 19. doi: 10.1371/journal.pone.0005603.

Copyright Hayashi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.