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==Mechanism of tetrabenazine inhibition== | ==Mechanism of tetrabenazine inhibition== | ||
VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release. | VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release. By inhibiting VMAT2, dopamine will not be packaged into vesicles and hence, unable to travel across the synaptic cleft. Tetrabenazine also binds and inhibit to dopamine receptors. This suppresses the amount of dopamine binding to the dopamine receptor located at the post synaptic nerve terminal. Thus, the neurones will not be stimulated and no cascade for the inducement of kinetic movements will be triggered. | ||
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Beginning six months after publication, I (Z3389806) grant the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. | Beginning six months after publication, I (Z3389806) grant the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. | ||
===Assessment=== | |||
+ Figure relavent to group project. | |||
+ Meets student drawn criteria. | |||
+ Copyright, citation and student disclaimer included. | |||
+ You provide further information in the figure legend, therefore some peer teaching component. | |||
- The most serious problem with this image is that it is of such poor quality that any of the positive assessment items above are discounted by this. You should have made an effort to upload a far clearer version. | |||
{{Template:2011 Student Image}} | {{Template:2011 Student Image}} | ||
Latest revision as of 15:27, 28 October 2011
Mechanism of tetrabenazine inhibition
VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release. By inhibiting VMAT2, dopamine will not be packaged into vesicles and hence, unable to travel across the synaptic cleft. Tetrabenazine also binds and inhibit to dopamine receptors. This suppresses the amount of dopamine binding to the dopamine receptor located at the post synaptic nerve terminal. Thus, the neurones will not be stimulated and no cascade for the inducement of kinetic movements will be triggered.
Based upon Tetrabenazine for the Treatment of Huntington’s Chorea
Drawn & uploaded by Z3389806.
Beginning six months after publication, I (Z3389806) grant the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode.
Assessment
+ Figure relavent to group project. + Meets student drawn criteria. + Copyright, citation and student disclaimer included. + You provide further information in the figure legend, therefore some peer teaching component. - The most serious problem with this image is that it is of such poor quality that any of the positive assessment items above are discounted by this. You should have made an effort to upload a far clearer version.
- Note - This image was originally uploaded as part of a student project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.
Cite this page: Hill, M.A. (2024, April 27) Embryology Mechanism of tetrabenazine.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mechanism_of_tetrabenazine.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 19:43, 20 September 2011 |  | 600 × 459 (33 KB) | Z3389806 (talk | contribs) | Reverted to version as of 09:41, 20 September 2011 |
| 19:43, 20 September 2011 |  | 600 × 459 (33 KB) | Z3389806 (talk | contribs) | ==Mechanism of tetrabenazine inhibition== VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release.[92] By inhibiting VMAT2, dopamine will not be packaged into vesicles and hence, u | |
| 19:41, 20 September 2011 |  | 600 × 459 (33 KB) | Z3389806 (talk | contribs) | ==Mechanism of tetrabenazine inhibition== VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release.[92] By inhibiting VMAT2, dopamine will not be packaged into vesicles and hence, u | |
| 20:14, 19 September 2011 |  | 2,448 × 1,872 (221 KB) | Z3389806 (talk | contribs) | ==Mechanism of tetrabenazine inhibition== VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release.[92] By inhibiting VMAT2, dopamine will not be packaged into vesicles and hence, u |
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