File:Limb induction-initiation signal 02.jpg: Difference between revisions

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Molecular Mechanisms of Limb Bud Formation

Figure from study that dshows the shared role of RA in forelimb and hindlimb and an evolutionarily conserved role of the b-catenin pathway in limb induction.

A - During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces retinoids acid (RA) locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the late real plate mesoderm (LPM).

B - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expression. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).

C and D - Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D).

Human TBX Family

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
Table - Human Tbx Family
TBX1	T-box 1	VCF	CATCH22	22q11.21
TBX2	T-box 2			17q23.2
TBX3	T-box 3	UMS	"TBX3-ISO, XHL"	12q24.21
TBX4	T-box 4			17q23.2
TBX5	T-box 5	HOS		12q24.21
TBX6	T-box 6			16p11.2
TBX10	T-box 10	TBX7	TBX13	11q13.2
TBX15	T-box 15	TBX14		1p12
TBX18	T-box 18			6q14.3
TBX19	T-box 19		"dj747L4.1, TPIT"	1q24.2
TBX20	T-box 20			7p14.2
TBX21	T-box 21		"TBLYM, T-bet"	17q21.32
TBX22	T-box 22	"CPX, CLPA"		Xq21.1
TBX23P	T-box 23, pseudogene	TBX23		1q25
TBR1	T-box, brain 1			2q24.2
EOMES	eomesodermin		TBR2	3p24.1
MGA	MGA, MAX dimerization protein		"KIAA0518, MAD5, MXD5, FLJ12634"	15q15
TBXT	T-box transcription factor T	T		6q27
Links: Developmental Signals - Tbx \| OMIM Tbx3 \| HGNC \| Bmp Family \| Sox Family \| Tbx Family

Human FGF Family

Approved Symbol	Approved Name	Previous Symbols	Synonyms	Chromosome
Table - Human Fibroblast Growth Factor Family FGF
FGF1	fibroblast growth factor 1	FGFA	"AFGF, ECGF, ECGFA, ECGFB, HBGF1, ECGF-beta, FGF-alpha, GLIO703"	5q31.3
FGF2	fibroblast growth factor 2	FGFB		4q28.1
FGF4	fibroblast growth factor 4	HSTF1	"K-FGF, HBGF-4, HST, HST-1, KFGF"	11q13.3
FGF5	fibroblast growth factor 5			4q21.21
FGF6	fibroblast growth factor 6			12p13.32
FGF7	fibroblast growth factor 7		KGF	15q21.2
FGF8	fibroblast growth factor 8		AIGF	10q24.32
FGF9	fibroblast growth factor 9			13q12.11
Links: Developmental Signals - Fibroblast Growth Factor \| OMIM Fgf1 \| HGNC \| Bmp Family \| Fgf Family \| Sox Family \| Tbx Family

Reference

Nishimoto S, Wilde SM, Wood S & Logan MP. (2015). RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation. Cell Rep , 12, 879-91. PMID: 26212321 DOI.

Copyright

Figure 7. resized and labeled with PMID.

Cite this page: Hill, M.A. (2024, April 27) Embryology Limb induction-initiation signal 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Limb_induction-initiation_signal_02.jpg

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	13:13, 13 September 2016		1,280 × 1,009 (124 KB)	Z8600021 (talk \| contribs)	Figure 7. The Molecular Mechanisms of Limb Bud Formation (A) During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LP...

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Molecular Development - Signaling

@@ Line 1: / Line 1: @@
-Figure 7. The Molecular Mechanisms of Limb Bud Formation
+==Molecular Mechanisms of Limb Bud Formation==
-(A) During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LPM.
+Figure from study that dshows the shared role of RA in forelimb and hindlimb and an evolutionarily conserved role of the b-catenin pathway in limb induction.
-(B) Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expres- sion. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).
-(C and D) Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D).
+'''A''' - During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces retinoids acid (RA) locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the late real plate mesoderm (LPM).
+'''B''' - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expression. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).
+'''C''' and '''D''' -  Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D).
+:[[Musculoskeletal System - Limb Development|'''Links''']]: [[:File:Limb induction-initiation signal 01.jpg|image - summary]] | [[:File:Limb induction-initiation signal 02.jpg|image - signal interaction]] | [[Developmental Signals - Retinoic acid|Retinoic acid]] | [[Developmental Signals - Tbx|Tbx]] | [[Developmental Signals - Fibroblast Growth Factor|FGF]] | [[Musculoskeletal System - Limb Development|Limb Development]]
+{{Tbx family collapsetable}}{{Fgf family collapsetable}}
+===Reference===
+{{#pmid:26212321}}
+====Copyright====
+Copyright © 2015 The Authors
+This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
+Figure 7. resized and labeled with PMID.
+{{Footer}}
+[[Category:Limb]][[Category:Cartoon]][[Category:FGF]][[Category:Retinoic acid]][[Category:Tbx]]