File:Limb induction-initiation signal 02.jpg: Difference between revisions

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Molecular Mechanisms of Limb Bud Formation

Study demonstrates the shared role of RA in forelimb and hindlimb and an evolutionarily conserved role of the b-catenin pathway in limb induction.

A - During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LPM.

B - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expres- sion. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).

Links: image - summary | image - signal interaction | Retinoic acid | Tbx

Reference

Copyright

Figure 7. resized and labeled with PMID.

Cite this page: Hill, M.A. (2024, April 27) Embryology Limb induction-initiation signal 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Limb_induction-initiation_signal_02.jpg

What Links Here?

(C and D) Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D).

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	13:13, 13 September 2016		1,280 × 1,009 (124 KB)	Z8600021 (talk \| contribs)	Figure 7. The Molecular Mechanisms of Limb Bud Formation (A) During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LP...

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Molecular Development - Signaling

@@ Line 1: / Line 1: @@
-Figure 7. The Molecular Mechanisms of Limb Bud Formation
+==Molecular Mechanisms of Limb Bud Formation==
-(A) During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LPM.
+Study demonstrates the shared role of RA in forelimb and hindlimb and an evolutionarily conserved role of the b-catenin pathway in limb induction.
-(B) Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expres- sion. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).
+'''A''' - During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LPM.
+'''B''' - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expres- sion. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).
+:'''Links:''' [[:File:Limb induction-initiation signal 01.jpg|image - summary]] | [[:File:Limb induction-initiation signal 02.jpg|image - signal interaction]] | [[Developmental Signals - Retinoic acid|Retinoic acid]] | [[Developmental Signals - Tbx|Tbx]]
+===Reference===
+<pubmed>26212321</pubmed>
+====Copyright====
+Copyright © 2015 The Authors
+This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
+Figure 7. resized and labeled with PMID.
+{{Footer}}
+[[Category:Limb]][[Category:Cartoon]][
 (C and D) Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D).