File:Limb induction-initiation signal 01.jpg

From Embryology

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Molecular Mechanisms of Limb Bud Formation

Nishimoto et al. reveal the regulatory network including retinoic acid (RA), b-catenin pathway, and Tbx genes controlling the early steps of limb formation. This study demonstrates the shared role of RA in forelimb and hindlimb and an evolutionarily conserved role of the b-catenin pathway in limb induction.

Links: image - summary | image - signal interaction | Retinoic acid | Tbx | FGF | Limb Development


Nishimoto S, Wilde SM, Wood S & Logan MP. (2015). RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation. Cell Rep , 12, 879-91. PMID: 26212321 DOI.


Copyright © 2015 The Authors This is an open access article under the CC BY license (

Cite this page: Hill, M.A. (2024, March 2) Embryology Limb induction-initiation signal 01.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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