File:Lens-neural crest signaling 01.jpg

From Embryology

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Wnt mediates lens repression by neural crest cells and Transforming growth factor-β

  • Transforming growth factor β (TGF-β)
  • Neural crest cell (NCC)

Proposed embryological model summarizing how NCCs organize the eye:

  1. NCCs (blue) secrete TGF-βs, which signal to the non-lens ectoderm and dorsal optic vesicle.
  2. As a consequence, Wnt2b (red) is induced, and together they repress lens formation in the non-lens ectoderm.
  3. This leads to the alignment of Pax6 expression in the future lens and neural retina (grey).


Links: Lens Development | Lens repression by neural crest cells | Proposed model how NCCs organize the eye | molecular model to explain TGF-β- and Wnt-mediated lens restriction


Original image name: Figure 3 http://www.nature.com/ncomms/journal/v2/n4/fig_tab/ncomms1269_F3.html (panel S cropped from complete figure)

Lens-neural crest signaling 01.jpg

Reference

Grocott T, Johnson S, Bailey AP, Streit A. Neural crest cells organize the eye via TGF-β and canonical Wnt signalling. Nat Commun. 2011 Apr;2:265. PMID21468017 | Nat Commun.


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current15:05, 29 April 2011Thumbnail for version as of 15:05, 29 April 2011300 × 400 (24 KB)S8600021 (talk | contribs)==Wnt mediates lens repression by neural crest cells and Transforming growth factor-β== * Transforming growth factor β (TGF-β) * Neural crest cell (NCC) (s) Proposed embryological model summarizing how NCCs organize the eye: NCCs (blue) secrete TGF-

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