File:Integumentary touch dome model 01.jpg

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Model for developmental signaling requirements for touch dome Merkel cell production

The touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs).

(left) Model of the signaling cascade that regulates the development of TD MCs and their adjacent guard hair follicle, along with experimental interventions that disrupted or rescued the developmental processes. (right) Graphical representation of the sequential signaling mechanisms that drive TD MC specification in embryonic mouse skin. TD MC specification requires mesenchymal Wnt signaling which allows Eda signaling to Edar in the developing primary hair placodes and subsequent Shh signaling from the primary hair placodes/germs to adjacent ectoderm containing the TD anlages. Square cells, surface ectoderm. Trapezoidal cells, hair placode/germ cells. Oval cells, periderm.

Integumentary Links: integumentary | Lecture | hair | tooth | nail | integumentary gland | mammary gland | vernix caseosa | melanocyte | touch | Eyelid | outer ear | Histology | integumentary abnormalities | Category:Integumentary
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Touch Links: Touch Receptors | Touch Pathway | Pacinian Corpuscle | Meissner's Corpuscle | Merkel Cell | Sensory Modalities | Neural Crest Development | Neural System Development | Student project | Integumentary | Sensory System
Historic Embryology - Integumentary  
1906 Papillary ridges | 1910 Manual of Human Embryology | 1914 Integumentary | 1923 Head Subcutaneous Plexus | 1921 Text-Book of Embryology | 1924 Developmental Anatomy | 1941 Skin Sensory | Historic Disclaimer



Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, et al. (2016) A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet 12(7): e1006150. doi:10.1371/journal.pgen.1006150


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Fig 7. doi:10.1371/journal.pgen.1006150.g007

Cite this page: Hill, M.A. (2024, April 25) Embryology Integumentary touch dome model 01.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current14:34, 12 August 2017Thumbnail for version as of 14:34, 12 August 20171,280 × 724 (144 KB)Z8600021 (talk | contribs)==Proposed model of the developmental signaling requirements for TD MC production== touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs) (left) Model of the signaling cascade that regulates the development o...