File:Implantation cartoon 02.jpg

From Embryology

Original file(950 × 1,000 pixels, file size: 161 KB, MIME type: image/jpeg)

Key Molecules for Decidualization

Legend
Key molecules for decidualization are depicted in this hybrid cartoon as gathered from mouse and human studies. The decidua is composed of differentiated stromal (decidual) cells, many of which are terminally differentiated (polyploid).


Decidualization involves coordination of several processes, including polyploidy, and several types of molecules, such as cytokine receptors, enzymes, morphogens, hormones and transcription factors.

  • ADM - adrenomedullin
  • BV - blood vessel
  • DEDD - death effector domain–containing protein
  • IL-11Rα - interleukin 11 receptor α
  • mTORC1 - mammalian target of rapamycin complex 1
  • SGK1 - serum- and glucocorticoid-inducible kinase 1
  • Sphk1/2 - sphingosine kinase 1/2

Adrenomedullin - secreted by both decidual and trophoblast cells, angiogenic and natriuretic factor both promoting growth.


Links: Implantation | Week 2

Reference

Cha J, Sun X & Dey SK. (2012). Mechanisms of implantation: strategies for successful pregnancy. Nat. Med. , 18, 1754-67. PMID: 23223073 DOI.

Copyright

Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy. Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012)

Nm.3012-F2.jpg


Cite this page: Hill, M.A. (2024, April 13) Embryology Implantation cartoon 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Implantation_cartoon_02.jpg

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current17:47, 18 March 2013Thumbnail for version as of 17:47, 18 March 2013950 × 1,000 (161 KB)Z8600021 (talk | contribs) Key molecules for decidualization are depicted in this hybrid cartoon as gathered from mouse and human studies. The decidua is composed of differentiated stromal (decidual) cells, many of which are terminally differentiated (polyploid). Decidualizatio...