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Human Thyroid System Development

Timeline of human thyroid system and brain development from conception to birth. Estimation of neurogenesis adapted from Bayer et al. (1993).

  • Development of the human thyroid gland begins in the third week of gestation.
  • GD 16-17 - embryonic thyroid is visible as an outgrowth in the floor of the primitive buccal cavity (the site of the future pharynx).
    • Additional lateral contributions to the embryonic thyroid originate from a portion of the fourth pharyngeal pouches; these lateral contributions are the origin of the C-cells, which produce calcitonin.
  • GD29 - thyroglobulin (TBG), the precursor protein upon which thyroid hormone is produced and stored, is initially detected in thyroid follicle cells.
  • GD45-50 - thyroid gland tissues merge and migrate to their final location.
  • GD70 - thyroid gland is well developed; it begins concentrating iodide and producing thyroid hormone at this time (3).
  • GW11 - TBG levels are detected in fetal serum as thyroid follicle cells mature, and continues to increase through gestation.


GD = gestation day GW = gestational week TBG = thyroglobulin


Links: Thyroid Development | Iodine Deficiency | Neural System Development

Reference

Howdeshell KL. (2002). A model of the development of the brain as a construct of the thyroid system. Environ. Health Perspect. , 110 Suppl 3, 337-48. PMID: 12060827

Bayer SA, Altman J, Russo RJ & Zhang X. (1993). Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology , 14, 83-144. PMID: 8361683

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Cite this page: Hill, M.A. (2024, April 20) Embryology Human thyroid system and neural development.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Human_thyroid_system_and_neural_development.jpg

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current19:14, 3 August 2010Thumbnail for version as of 19:14, 3 August 20101,032 × 728 (132 KB)S8600021 (talk | contribs)==Human Thyroid System Development== Timeline of human thyroid system and brain development from conception to birth. Estimation of neurogenesis adapted from Bayer et al. <pubmed>8361683</pubmed> Development of the human thyroid gland begins in the thir