File:Frog germ layer signaling 01.jpg: Difference between revisions
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==Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning== | ==Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning== | ||
(B) Model of TSK function in Xenopus germ layer formation and patterning: dorsal-ventral mesoderm patterning. X-TSK in dorsal mesoderm (red) inhibits BMP signaling to promote dorsal mesoderm formation, as marked by Gsc expression. This is possibly also enhanced through activation of Xnr2 signals by TSK. MAPK activation inhibits X-TSK expression in ventrolateral mesoderm, where X-TSK inhibits expression of ventrolateral mesoderm markers such as Xbra, through inhibition of FGF signaling. This network of signaling may contribute to clear patterning of the mesoderm. | |||
(C) Model of TSK function in endoderm formation. X-TSK coordinates inhibition of FGF and BMP signals with activation of Xnr2 signaling to induce endoderm formation (green), as marked by Sox17α. Again, X-TSK inhibits expression of ventrolateral mesoderm (blue) markers such as Xbra, through inhibition of FGF signaling and may contribute to the distinction between endoderm and mesoderm specific gene expression. | |||
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===Reference=== | ===Reference=== |
Latest revision as of 13:41, 11 October 2012
Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning
(B) Model of TSK function in Xenopus germ layer formation and patterning: dorsal-ventral mesoderm patterning. X-TSK in dorsal mesoderm (red) inhibits BMP signaling to promote dorsal mesoderm formation, as marked by Gsc expression. This is possibly also enhanced through activation of Xnr2 signals by TSK. MAPK activation inhibits X-TSK expression in ventrolateral mesoderm, where X-TSK inhibits expression of ventrolateral mesoderm markers such as Xbra, through inhibition of FGF signaling. This network of signaling may contribute to clear patterning of the mesoderm.
(C) Model of TSK function in endoderm formation. X-TSK coordinates inhibition of FGF and BMP signals with activation of Xnr2 signaling to induce endoderm formation (green), as marked by Sox17α. Again, X-TSK inhibits expression of ventrolateral mesoderm (blue) markers such as Xbra, through inhibition of FGF signaling and may contribute to the distinction between endoderm and mesoderm specific gene expression.
Reference
<pubmed>17925852</pubmed>| PMC1994590 | PLoS ONE
Citation: Morris SA, Almeida AD, Tanaka H, Ohta K, Ohnuma S-i (2007) Tsukushi Modulates Xnr2, FGF and BMP Signaling: Regulation of Xenopus Germ Layer Formation. PLoS ONE 2(10): e1004. doi:10.1371/journal.pone.0001004
Copyright: © 2007 Morris et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Figure 10. Journal.pone.0001004.g010.jpg
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current | 13:34, 11 October 2012 | 600 × 350 (44 KB) | Z8600021 (talk | contribs) | ==Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning== (A) Semi-quantitative RT-PCR of X-TSK expression in animal caps injected with 1 ng XFD, 50 pg V-ras or 50 pg caFGFR. WE = Whole embryo, WOC = Water |
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