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==Folate one-carbon metabolism==
Summary of folate one-carbon metabolism showing the main pathways and reactions that have been subject to analysis in the context of NTDs.  
Summary of folate one-carbon metabolism showing the main pathways and reactions that have been subject to analysis in the context of NTDs.  


Blue shading: proteins involved in processing of folates in the digestive tract, transport and cellular retention (by addition of glutamates).  
* Blue shading: proteins involved in processing of folates in the digestive tract, transport and cellular retention (by addition of glutamates).
* Yellow shading: the major part of the cycle involving transfer of 1C groups between folate molecules, as required for purine and pyrimidine biosynthesis.
* Pink shading: reactions of the methylation cycle.  


Yellow shading: the major part of the cycle involving transfer of 1C groups between folate molecules, as required for purine and pyrimidine biosynthesis.  
For clarity, mitochondrial reactions that include generation of formate and cleavage of glycine have been omitted.


Pink shading: reactions of the methylation cycle.
===Reference===
<pubmed>19808787</pubmed>


For clarity, mitochondrial reactions that include generation of formate and cleavage of glycine have been omitted.
====Copyright====


Figure 1. http://hmg.oxfordjournals.org/cgi/content/full/18/R2/R113/DDP347F1
© 2009 Greene ND, Stanier P, Copp AJ.  
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Genetics of human neural tube defects. Greene ND, Stanier P, Copp AJ. Hum Mol Genet. 2009 Oct 15;18(R2):R113-29. Review. [http://www.ncbi.nlm.nih.gov/pubmed/19808787 PMID: 19808787] | [http://hmg.oxfordjournals.org/cgi/content/full/18/R2/R113 Hum Mol Genet.]
Genetics of human neural tube defects. Greene ND, Stanier P, Copp AJ. Hum Mol Genet. 2009 Oct 15;18(R2):R113-29. Review. [http://www.ncbi.nlm.nih.gov/pubmed/19808787 PMID: 19808787] | [http://hmg.oxfordjournals.org/cgi/content/full/18/R2/R113 Hum Mol Genet.]


Figure 1. http://hmg.oxfordjournals.org/cgi/content/full/18/R2/R113/DDP347F1


© 2009 The Author(s)
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


[[Category:Neural] [[Category:Abnormal Development]]
[[Category:Neural] [[Category:Abnormal Development]]

Revision as of 09:56, 12 October 2015

Folate one-carbon metabolism

Summary of folate one-carbon metabolism showing the main pathways and reactions that have been subject to analysis in the context of NTDs.

  • Blue shading: proteins involved in processing of folates in the digestive tract, transport and cellular retention (by addition of glutamates).
  • Yellow shading: the major part of the cycle involving transfer of 1C groups between folate molecules, as required for purine and pyrimidine biosynthesis.
  • Pink shading: reactions of the methylation cycle.

For clarity, mitochondrial reactions that include generation of formate and cleavage of glycine have been omitted.

Reference

<pubmed>19808787</pubmed>

Copyright

© 2009 Greene ND, Stanier P, Copp AJ. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Genetics of human neural tube defects. Greene ND, Stanier P, Copp AJ. Hum Mol Genet. 2009 Oct 15;18(R2):R113-29. Review. PMID: 19808787 | Hum Mol Genet.

Figure 1. http://hmg.oxfordjournals.org/cgi/content/full/18/R2/R113/DDP347F1


Cite this page: Hill, M.A. (2024, May 8) Embryology Folate one-carbon metabolism.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Folate_one-carbon_metabolism.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G


[[Category:Neural]

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current13:12, 22 April 2010Thumbnail for version as of 13:12, 22 April 2010600 × 602 (69 KB)S8600021 (talk | contribs)Summary of folate one-carbon metabolism showing the main pathways and reactions that have been subject to analysis in the context of NTDs. Blue shading: proteins involved in processing of folates in the digestive tract, transport and cellular retention