File:Fgf gene family evolution.jpg
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Evolutionary history of the Fgf gene family
Fgf13-like is an ancestral gene of the Fgf family. Fgf4-like is an ancestral gene of the canonical Fgf family. Fgf4-like was generated from Fgf13-like by gene duplication. Fgf15/19-like, an ancestral gene of the hormone-like Fgf subfamily, was generated from Fgf4-like by local gene duplication early in vertebrate evolution. Later, Fgf15/19, Fgf21, and Fgf23 were generated by two large-scale genome duplication events during the evolution of early vertebrates
Original file name: Fig. 1 441_2010_1024_Fig1_HTML.jpg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948652/figure/Fig1/
Reference
Cell Tissue Res. 2010 Oct;342(1):1-11. Epub 2010 Aug 24. Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease. Itoh N.Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan. itohnobu@pharm.kyoto-u.ac.jp http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948652
Cell Tissue Res. 2010 October; 342(1): 1–11. Published online 2010 August 24. doi: 10.1007/s00441-010-1024-2.
Copyright © The Author(s) 2010
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 09:16, 7 October 2015 | | 759 × 400 (49 KB) | Z8600021 (talk | contribs) | increase size add PMID 20730630 |
| 23:31, 3 May 2011 |  | 488 × 257 (51 KB) | S8600021 (talk | contribs) | ==Evolutionary history of the Fgf gene family== Fgf13-like is an ancestral gene of the Fgf family. Fgf4-like is an ancestral gene of the canonical Fgf family. Fgf4-like was generated from Fgf13-like by gene duplication. Fgf15/19-like, an ancestral gene o |
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