File:Epigenetics - monozygous twins.jpg: Difference between revisions
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"...We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype." | "...We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype." | ||
<pubmed>16009939</pubmed> | <pubmed>16009939</pubmed> | ||
Image Copyright (2005) National Academy of Sciences, U.S.A | Image Copyright (2005) National Academy of Sciences, U.S.A | ||
[[Category:Molecular]] | |||
Revision as of 12:03, 1 July 2010
DNA methylation in young and old monozygous twins
Chromosome regions with differential DNA methylation in young and old monozygous twins.
Significant DNA methylation changes are indicated as thick red and green blocks in the ideograms.
The 3-year-old twins have a very similar DNA methylation (yellow).
The 50-year-old twin pair shows abundant changes in the pattern of DNA methylation (green=hypermethylation and red=hypomethylation).
"...We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype."
<pubmed>16009939</pubmed>
Image Copyright (2005) National Academy of Sciences, U.S.A
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 11:53, 1 July 2010 |  | 450 × 540 (78 KB) | S8600021 (talk | contribs) | ==DNA methylation in young and old monozygous twins== Chromosome regions with differential DNA methylation in young and old monozygous twins. Significant DNA methylation changes are indicated as thick red and green blocks in the ideograms. The 50-year |
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