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Located within the cell nucleus these bodies have also been called: nucleolar accessory bodies, coiled body, gems. Their size is about 0.1 - 2.0 microns, numbering about 1 to 10 in each nucleus. Proposed sites where small nuclear ribonucleoproteins (snRNPs) and small nucleolar RNAs (snoRNPs) are modified. | Located within the cell nucleus these bodies have also been called: nucleolar accessory bodies, coiled body, gems. Their size is about 0.1 - 2.0 microns, numbering about 1 to 10 in each nucleus. Proposed sites where small nuclear ribonucleoproteins (snRNPs) and small nucleolar RNAs (snoRNPs) are modified. | ||
[[Embryology_History_-_Santiago_Ramón_y_Cajal|Ramón y Cajal]] first identified and christened them "nucleolar accessory bodies". | [[Embryology_History_-_Santiago_Ramón_y_Cajal|Ramón y Cajal]] first identified and christened them "nucleolar accessory bodies".{{#pmid:14685175|PMID14685175}} | ||
(A) HeLa cells expressing an FP–coilin fusion protein (arrows indicate Cajal bodies). | |||
(B) Fluorescence micrograph of purified CBs immunolabeled with anticoilin antibodies. | |||
([[:File:Cajal body EM.jpg|'''C''']]) Field emission scanning electron micrograph of a purified CB. | |||
(D) Transmission electron micrograph of a purified CB. Coilin is immunolabeled with 5 nm gold (arrows) and SMN is immunolabeled with 10 nm gold (arrowheads). | |||
Bars: (A and B) 10 μm; (C) 500 nm; (D) 200 nm. | Bars: (A and B) 10 μm; (C) 500 nm; (D) 200 nm. | ||
( | [https://www.omim.org/entry/600354 SMN1] - ({{Chr5}}q13) encodes a 38 kD protein located in Cajal bodies associated with {{Spinal muscular atrophy}}. | ||
{{Fragile X}} protein (FMRP) isoforms 6 and 12 (ISO6 and 12) have been localized to the Cajal bodies in cultured human cells.{{#pmid:24204304|PMID24204304}} {{Fragile X Syndrome}} (FXS) is the most common form of inherited mental retardation and autism. | |||
:'''Links:''' [[: File:Fragile_X_protein_ISO6_and_Cajal_bodies.jpg|Image - FMRP and Cahal bodies]] | [[Embryology_History_-_Santiago_Ramón_y_Cajal|Cajal]] | | :'''Links:''' {{Spinal muscular atrophy}} | [[: File:Fragile_X_protein_ISO6_and_Cajal_bodies.jpg|Image - FMRP and Cahal bodies]] | [[Embryology_History_-_Santiago_Ramón_y_Cajal|Cajal]] | {{Fragile X Syndrome}} | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Cajal+Bodies Search PubMed] | ||
===Reference=== | ===Reference=== | ||
{{#pmid:12379800}} | |||
<references/> | |||
{{JCB}} | {{JCB}} | ||
Figure 1. relabelled and resized. | Figure 1. relabelled and resized. | ||
Latest revision as of 12:22, 15 October 2018
Nucleus - Cajal Bodies
Located within the cell nucleus these bodies have also been called: nucleolar accessory bodies, coiled body, gems. Their size is about 0.1 - 2.0 microns, numbering about 1 to 10 in each nucleus. Proposed sites where small nuclear ribonucleoproteins (snRNPs) and small nucleolar RNAs (snoRNPs) are modified.
Ramón y Cajal first identified and christened them "nucleolar accessory bodies".[1]
(A) HeLa cells expressing an FP–coilin fusion protein (arrows indicate Cajal bodies).
(B) Fluorescence micrograph of purified CBs immunolabeled with anticoilin antibodies.
(C) Field emission scanning electron micrograph of a purified CB.
(D) Transmission electron micrograph of a purified CB. Coilin is immunolabeled with 5 nm gold (arrows) and SMN is immunolabeled with 10 nm gold (arrowheads).
Bars: (A and B) 10 μm; (C) 500 nm; (D) 200 nm.
SMN1 - (5q13) encodes a 38 kD protein located in Cajal bodies associated with Spinal muscular atrophy.
Fragile X protein (FMRP) isoforms 6 and 12 (ISO6 and 12) have been localized to the Cajal bodies in cultured human cells.[2] Fragile X Syndrome (FXS) is the most common form of inherited mental retardation and autism.
- Links: Spinal muscular atrophy | Image - FMRP and Cahal bodies | Cajal | Fragile X Syndrome | Search PubMed
Reference
Ogg SC & Lamond AI. (2002). Cajal bodies and coilin--moving towards function. J. Cell Biol. , 159, 17-21. PMID: 12379800 DOI.
- ↑ Gall JG. (2003). The centennial of the Cajal body. Nat. Rev. Mol. Cell Biol. , 4, 975-80. PMID: 14685175 DOI.
- ↑ Dury AY, El Fatimy R, Tremblay S, Rose TM, Côté J, De Koninck P & Khandjian EW. (2013). Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. PLoS Genet. , 9, e1003890. PMID: 24204304 DOI.
Copyright
Rockefeller University Press - Copyright Policy This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/ ). (More? Help:Copyright Tutorial)
Figure 1. relabelled and resized.
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| 11:53, 13 August 2014 |  | 640 × 515 (69 KB) | Z8600021 (talk | contribs) | ==Nucleus - Cajal Bodies== (A) HeLa cells expressing an FP–coilin fusion protein (arrows indicate Cajal bodies). (B) Fluorescence micrograph of purified CBs immunolabeled with anticoilin antibodies. (C) Field emission scanning electron micrograph... |
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