File:Cajal bodies PMID12379800.jpg
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Nucleus - Cajal Bodies
Located within the cell nucleus these bodies have also been called: nucleolar accessory bodies, coiled body, gems. Their size is about 0.1 - 2.0 microns, numbering about 1 to 10 in each nucleus. Proposed sites where small nuclear ribonucleoproteins (snRNPs) and small nucleolar RNAs (snoRNPs) are modified.
Ramón y Cajal first identified and christened them "nucleolar accessory bodies".[1]
(A) HeLa cells expressing an FP–coilin fusion protein (arrows indicate Cajal bodies).
(B) Fluorescence micrograph of purified CBs immunolabeled with anticoilin antibodies.
(C) Field emission scanning electron micrograph of a purified CB.
(D) Transmission electron micrograph of a purified CB. Coilin is immunolabeled with 5 nm gold (arrows) and SMN is immunolabeled with 10 nm gold (arrowheads).
Bars: (A and B) 10 μm; (C) 500 nm; (D) 200 nm.
SMN1 - (5q13) encodes a 38 kD protein located in Cajal bodies associated with Spinal muscular atrophy.
Fragile X protein (FMRP) isoforms 6 and 12 (ISO6 and 12) have been localized to the Cajal bodies in cultured human cells.[2] Fragile X Syndrome (FXS) is the most common form of inherited mental retardation and autism.
- Links: Spinal muscular atrophy | Image - FMRP and Cahal bodies | Cajal | Fragile X Syndrome | Search PubMed
Reference
Ogg SC & Lamond AI. (2002). Cajal bodies and coilin--moving towards function. J. Cell Biol. , 159, 17-21. PMID: 12379800 DOI.
- ↑ Gall JG. (2003). The centennial of the Cajal body. Nat. Rev. Mol. Cell Biol. , 4, 975-80. PMID: 14685175 DOI.
- ↑ Dury AY, El Fatimy R, Tremblay S, Rose TM, Côté J, De Koninck P & Khandjian EW. (2013). Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. PLoS Genet. , 9, e1003890. PMID: 24204304 DOI.
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Figure 1. relabelled and resized.
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| current | 13:19, 13 August 2015 | | 1,280 × 1,029 (204 KB) | Z8600021 (talk | contribs) | |
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| 11:53, 13 August 2014 |  | 640 × 515 (69 KB) | Z8600021 (talk | contribs) | ==Nucleus - Cajal Bodies== (A) HeLa cells expressing an FP–coilin fusion protein (arrows indicate Cajal bodies). (B) Fluorescence micrograph of purified CBs immunolabeled with anticoilin antibodies. (C) Field emission scanning electron micrograph... |
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