File:BMP syndactyly.jpg

Depletion of BMP Signaling Causes Interdigital Syndactyly

(A–D) Forelimb of adult wild-type

(A) and Bmp2C/C; Prx1::cre mouse

(B) and hindlimbs of newborn wild-type

(C) mouse and newborn Bmp2C/C; Bmp4C/C; Prx1::cre

(D) mouse. The black arrow in (B) shows soft tissue syndactyly in Bmp2C/C; Prx1::cre mouse.

(E and F) Wild-type and Bmp2C/C; Bmp4C/C; Prx1::cre, respectively, showing acridine orange–stained hindlimbs of E15.5 mouse embryos. Acridine orange stain is in yellow.

(G and H) Enlarged views of selected regions from (E) and (F), respectively. Black arrow in (G) and (H) show acridine orange–stained apoptotic cells in the interdigital mesenchyme, and asterisk in (H) shows the remnant of the AER. (I and J) Fgf8 mRNA expression in the hindlimbs of E13.5 wild-type (I) and Bmp2C/C; Bmp4C/C; Prx1::cre (J) embryos. The thick black arrows in (J) show Fgf8 mRNA expression.

Reference

<pubmed>17194222</pubmed>| PMC1713256 | [1]

Copyright : © 2006 Bandyopadhyay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.