File:BMP syndactyly.jpg

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Depletion of BMP Signaling Causes Interdigital Syndactyly

(A–D) Forelimb of adult wild-type

(A) and Bmp2C/C; Prx1::cre mouse

(B) and hindlimbs of newborn wild-type

(C) mouse and newborn Bmp2C/C; Bmp4C/C; Prx1::cre

(D) mouse. The black arrow in (B) shows soft tissue syndactyly in Bmp2C/C; Prx1::cre mouse.

(E and F) Wild-type and Bmp2C/C; Bmp4C/C; Prx1::cre, respectively, showing acridine orange–stained hindlimbs of E15.5 mouse embryos. Acridine orange stain is in yellow.

(G and H) Enlarged views of selected regions from (E) and (F), respectively. Black arrow in (G) and (H) show acridine orange–stained apoptotic cells in the interdigital mesenchyme, and asterisk in (H) shows the remnant of the AER.

(I and J) Fgf8 mRNA expression in the hindlimbs of E13.5 wild-type (I) and Bmp2C/C; Bmp4C/C; Prx1::cre (J) embryos. The thick black arrows in (J) show Fgf8 mRNA expression.


Links: Image - hindlimb apoptosis | full image | Limb Development | Apoptosis | Mouse Development

Reference

Bandyopadhyay A, Tsuji K, Cox K, Harfe BD, Rosen V & Tabin CJ. (2006). Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet. , 2, e216. PMID: 17194222 DOI.

Copyright

© 2006 Bandyopadhyay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Cite this page: Hill, M.A. (2024, June 16) Embryology BMP syndactyly.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:BMP_syndactyly.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current10:28, 11 September 2009Thumbnail for version as of 10:28, 11 September 2009417 × 1,073 (70 KB)S8600021 (talk | contribs)Depletion of BMP Signaling Causes Interdigital Syndactyly (A–D) Forelimb of adult wild-type (A) and Bmp2C/C; Prx1::cre mouse (B) and hindlimbs of newborn wild-type (C) mouse and newborn Bmp2C/C; Bmp4C/C; Prx1::cre (D) mouse. The black arrow in

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