File:Adrenal and gonad early development.jpg

Adrenal and Gonad Early Development

The key events of steroidogenic tissues development in mice are shown. Molecular players in male sex (SRY, SOX9, SF-1, Dax-1) and female sex determination (Wnt4, Dax-1) are shown. Dax-1 function in sex determination is still unclear.

Steroidogenic Factor 1

• 53 kDa protein called Ad4BP (Adrenal 4 Binding Protein) or SF-1 (Steroidogenic Factor 1)
• classical DNA-binding domain (DBD) characterized by two Cys2-Cys2 zinc fingers in the N-terminal region
• SF-1 binds DNA as a monomer
• high homology with the drosophila Ftz-F1 transcription factor that controls fushi tarazu homeotic gene expression

Original file name: Figure 2. 1478-1336-1-8-2-l.jpg http://www.nuclear-receptor.com/content/1/1/8/figure/F2 (cartoon cropped from full image)

Reference

<pubmed>14594453</pubmed>| Nucl Recept.

Val et al. Nuclear Receptor 2003 1:8 doi:10.1186/1478-1336-1-8 http://www.nuclear-receptor.com/content/1/1/8

© 2003 Val et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.