Developmental Mechanism - Left-Right Axis
Embryology - 2 May 2024 Expand to Translate |
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Introduction
Draft Page - notice removed when complete.
How do you establish the anatomical axes of the embryo? Another well studied model of axis patterning is the establishment of limb axes, in particular this system historically was studied by grafting and rotating parts of the early developing limb.
Note there is some confusion arising in the terminology when comparing animal developmental axes and those of human anatomical axes.
Left-right axis (L-R) transverse plane
- vertebrates - left side Nodal expression
- sea urchins - right side Nodal expression, inhibit the right mesodermal coelomic pouch (CP) from forming the adult rudiment
Signaling Factors
- Nodal - induces its own expression and that of Lefty.
- Lefty - a Nodal feedback inhibitor with a longer diffusion range.
Primitive node cilia (human stage 8) | Embryo left-right asymmetry pathway[1] |
Axes Formation: Dorsal-Ventral Axis | Cranio-Caudal Axis | Left-Right Axis
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Left-Right Axis <pubmed limit=5>Left-Right Axis</pubmed> |
Nodal
Nodal is expressed during mouse gastrulation and is a member of the TGF-beta gene family.
- Links: OMIM601265
Lefty1
Lefty1 and Lefty2 are expressed in developing mouse embryos on the left side. These are members of the TGF-beta gene family.
- Links: OMIM603037
References
- ↑ <pubmed>23256866</pubmed>| BMC Biology
- ↑ <pubmed>26741372</pubmed>
Reviews
<pubmed></pubmed> <pubmed></pubmed>
Articles
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Glossary Links
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Cite this page: Hill, M.A. (2024, May 2) Embryology Developmental Mechanism - Left-Right Axis. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Left-Right_Axis
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G