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| {{Ref-Patten1951}} | | {{Ref-Patten1951}}<br> |
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| {{Patten1951 TOC}} | | {{Patten1951 TOC}} |
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| {{Historic Disclaimer}} | | {{Historic Disclaimer}} |
| =Embryology of the Pig= | | =Embryology of the Pig= |
| Frontispiece | | [[File:Bradley M. Patten.jpg|thumb|alt=Bradley M. Patten|link=Embryology History - Bradley Patten|Bradley Patten ( -1971)]] |
| | Frontispiece |
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| Reconstruction (X 17.5) showing the organ systems of a 9.4 mm. pig embryo. For explanation see figures 60 and 66. | | Reconstruction (X 17.5) showing the organ systems of a 9.4 mm. pig embryo. For explanation see figures 60 and 66. |
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| By BRADLEY M. PATTEN | | By Bradley M. Patten |
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| Professor of Anatomy in the University of Michigan Medical School | | Professor of Anatomy in the University of Michigan Medical School |
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| THIRD EDITION
| | Third Edition |
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| WITH COLORED FRONTISPIECE
| | With Colored Frontispiece |
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| AND 186 ILLUSTRATIONS IN THE TEXT (CONTAINING 412 FIGURES)
| | And 186 Illustrations In The Text (Containing 412 Figures) Of Which 6 Are In Color |
| OF WHICH 6 ARE IN COLOR
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| | Philadelphia : THE BLAKISTON COMPANY : Toronto |
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| Philadelphia : THE BLAKISTON COMPANY : Toronto
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| | Third Edition |
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| Third Edition
| | Copyright, October 1948, by The Blakiston Company |
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| Copyright, October 1948, by The Blakiston Company
| | By P. Blakiston's Son & Co. |
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| BY P. Blakiston ’s Son & Co.
| | Copyright, 1951, by P Blakiston's Son & Co , Inc. |
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| Copyright, 1951, by P Blakiston’s Son & Co , Inc.
| | {{Patten1951 TOC}} |
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| Preface to Third Edition | | ==Preface to Third Edition== |
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| | In making the revision for a new edition of this book it did not seem desirable essentially to change its form or scope. Effort has been concentrated on improving the presentation of the original subject matter and bringing it up to date, rather than on its expansion. The entire book has been reset to a greater page width which has permitted enlarging certain of the illustrations that, in earlier editions, had proved to be too greatly reduced. With the generous cooperation of the publishers several of the important plates on the cardiovascular system have been remade to a larger scale and with color. A number of new illustrations have been drawn for sections where experience has shown that students needed additional graphic assistance in interpreting their laboratory material. It is hoped that these changes will all contribute toward making the book as a whole more serviceable. |
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| In making the revision for a new edition of this book it did not
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| seem desirable essentially to change its form or scope. Effort has been
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| concentrated on improving the presentation of the original subject
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| matter and bringing it up to date, rather than on its expansion. The
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| entire book has been reset to a greater page width which has permitted enlarging certain of the illustrations that, in earlier editions,
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| had proved to be too greatly reduced. With the generous cooperation
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| of the publishers several of the important plates on the cardiovascular
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| system have been remade to a larger scale and with color. A number
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| of new illustrations have been drawn for sections where experience
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| has shown that students needed additional graphic assistance in
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| interpreting their laboratory material. It is hoped that these changes
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| will all contribute toward making the book as a whole more serviceable.
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| Bradley M. Patten | | Bradley M. Patten |
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| August 1048 | | August 1048 |
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| Preface to First Edition | | ==Preface to First Edition== |
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| | This book represents an endeavor to set forth in brief and simple form the fundamental facts of mammalian development. The thread of the story and the illustrations have been based on pig embryos because of their value and availability as laboratory material. But special stress has been laid on the embryological phenomena involved instead of on the details of specific conditions existing in the pig. Throughout the book, every efTort has been made to present developmental processes as dynamic events with emphasis on their sequence and significance, rather than as a series of still pictures of selected stages. |
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| This book represents an endeavor to set forth in brief and simple
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| form the fundamental facts of mammalian development. The thread
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| of the story and the illustrations have been based on pig embryos
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| because of their value and availability as laboratory material. But
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| special stress has been laid on the embryological phenomena involved
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| instead of on the details of specific conditions existing in the pig.
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| Throughout the book, every efTort has been made to present developmental processes as dynamic events with emphasis on their sequence
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| and significance, rather than as a series of still pictures of selected
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| stages.
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| Obviously no book can deal fully with all phases of development, | | Obviously no book can deal fully with all phases of development, even in a single form, and still remain serviceable as a text. As this book is for the student, it has seemed expedient, for the sake of clearness and simplicity, to omit many things which I should like to have included. My primary aim has been to write an account in which the essentials stand out adequately interpreted and unobscured by a multiplicity of details — to lay a foundation which can be further built upon in accordance with special needs or individual desires. |
| even in a single form, and still remain serviceable as a text. As this | |
| book is for the student, it has seemed expedient, for the sake of clearness and simplicity, to omit many things which I should like to have | |
| included. My primary aim has been to write an account in which the | |
| essentials stand out adequately interpreted and unobscured by a | |
| multiplicity of details — to lay a foundation which can be further | |
| built upon in accordance with special needs or individual desires. | |
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| Bradley M. Patten
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| January 1927
| | Bradley M. Patten |
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| | January 1927 |
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| ==Acknowledgment== | | ==Acknowledgment== |
| | The pleasantest thing about working on this book has been the generous aid I have received from many sources. Throughout the preparation of the initial edition the encouragement, criticism, and suggestions of my colleagues, Dr. F. C. Waite and Dr. S. W. Chase, were of the greatest help. In the preparation of material and in making the illustrations for the first edition the beautifully accurate work of Miss Kathryn Toulmin was of inestimable value. In making the new drawings added in the third edition I was fortunate in securing the unusually able assistance of Mrs. Dorothy Van Eck. |
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| The pleasantest thing about working on this book has been the
| | Dr. G. L. Streeter and Dr. C. H. Heuser of the Carnegie Institute allowed me free use of their extensive collection of young embryos and generously gave me many photographs made from their material. To Mrs. Charles S, Minot I am indebted for permission to use several figures from the late Professor Minot's works. The accrediting in the figure legends of these and other borrowed illustrations by no means covers my obligation to other writers. Practically the entire bibliography is a statement of indebtedness for information and ideas. |
| generous aid I have received from many sources. Throughout the
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| preparation of the initial edition the encouragement, criticism, and
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| suggestions of my colleagues, Dr. F. C. Waite and Dr. S. W. Chase,
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| were of the greatest help. In the preparation of material and in making
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| the illustrations for the first edition the beautifully accurate work of
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| Miss Kathryn Toulmin was of inestimable value. In making the new
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| drawings added in the third edition I was fortunate in securing the
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| unusually able assistance of Mrs. Dorothy Van Eck.
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| Dr. G. L. Streeter and Dr. C. H. Heuser of the Carnegie Institute
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| allowed me free use of their extensive collection of young embryos
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| and generously gave me many photographs made from their material.
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| To Mrs. Charles S, Minot I am indebted for permission to use several
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| figures from the late Professor Minot’s works. The accrediting in the
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| figure legends of these and other borrowed illustrations by no means
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| covers my obligation to other writers. Practically the entire bibliography is a statement of indebtedness for information and ideas.
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| I wish I might acknowledge individually the helpful services | | I wish I might acknowledge individually the helpful services rendered by many of my students, but they are too numerous. Several reconstructions which I have used directly or indirectly have been largely their work. Of even greater assistance have been their suggestions during the shaping of the work — suggestions of especial value because they were made from a point of view difficult for an instructor to appreciate without such aid. |
| rendered by many of my students, but they are too numerous. Several | |
| reconstructions which I have used directly or indirectly have been | |
| largely their work. Of even greater assistance have been their suggestions during the shaping of the work — suggestions of especial value | |
| because they were made from a point of view difficult for an instructor | |
| to appreciate without such aid. | |
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| To The Blakiston Company, I am indebted for much helpful
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| cooperation and especially for their liberality with regard to the
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| number and quality of the illustrations.
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| No person other than my wife could have deciphered and put
| | To The Blakiston Company, I am indebted for much helpful cooperation and especially for their liberality with regard to the number and quality of the illustrations. |
| into usable form manuscript of the character I frequently turned over
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| to her for revision and typing. Without her generous help the preparation of the text would have been much more arduous and long
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| delayed.
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| Bradley M. Patten
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| | No person other than my wife could have deciphered and put into usable form manuscript of the character I frequently turned over to her for revision and typing. Without her generous help the preparation of the text would have been much more arduous and long delayed. |
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| ==Chapter 12==
| | Bradley M. Patten |
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| Tke Histogenesis of Bone and tlie
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| Development of tke Skeletal System
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| | {{Footer}} |
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| I. Histogenesis of Bone
| | {{Patten1951 TOC}} |
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| Histologically bone belongs to the group of tissues known as the
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| connective and supporting tissues. In spite of their widely varying
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| adult conditions these.tissues are all similar in that the secreted parts,
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| rather than the cells themselves, carry out the functional role characteristic of the tissues. It is the secreted, fibrous portion of the binding
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| connective tissues which ties together various other tissues and
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| organs ; it is the secreted matrix of cartilage and of bone which affords
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| rigid support and protection to soft parts and furnishes a lever system
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| on which the muscles may be brought into play.
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| The cellular elements of these tissues must not be overlooked,
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| however, in emphasizing the functional importance of the cell
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| products. The cells are, so to speak, the power behind, in that they
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| extract the appropriate raw materials from the circulation, elaborate
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| them within their cytoplasm, and deposit the characteristic secretion
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| as an end-product. Moreover after the fiber is formed or the matrix
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| is laid down, it is dependent on the cells for maintenance in a healthy
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| active conditidn.
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| Embryologically the entire connective-tissue group arises from
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| mesenchymal cells. It is not surprising, in view of their closely related
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| functions and their derivation from a common type of ancestral cell,
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| that one type of connective tissue may be converted into or replaced
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| by another. This facility for changing the type of specialization is
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| sometimes referred to as plasticity.
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| The plasticity of the connective-tissue series is well exemplified
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| in the development of bone. Bone does not form in vacant spaces.
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| It is always laid down in an area already occupied by some less highly
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| specialized member of the connective-tissue family. The formation of
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| some bones begins in areas already occupied by connective tissue —
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| such bones are said to be intramembranous in origin, or are spoken
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| 271
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| 272 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
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| of as membrane bones. Other bones are laid down in areas already
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| occupied by cartilage. In this case they are said to be pndochondral in
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| origin, or, are called cartilage bones. It should be clearly borne in mind
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| that these terms apply solely to the method by which a bone develops
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| and do not imply any differences in histological structure, once the
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| bone is fully formed.
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| Likewise we should know at the outset what histologists mean
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| when they speak of cancellous bone and compact bone. These terms
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| refer not to the method of origin of the bone but to its density when
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| fully formed. Developmen tally all bone goes through the spongy or
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| cancellous stage. Some bones later become compact, others remain
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| cancellous. Most bones are compact in some areas and cancellous
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| in others.
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| The subject of bone development can be presented more simply
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| if we take up first the formation of primary cancellous bone intramembranously ; then the method by which this same type of spongy
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| bone is formed within cartilage, and finally the changes by which
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| cancellous bone, formed in either of the above ways, may become
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| secondarily compact.
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| Intramembranous Formation of Primary Cancellous Bone. In
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| an area where intramembranous bone formation is about to begin
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| we find an abundance of mesenchymal cells congregated and numerous small blood vessels present. The mesenchymal cells soon exhibit a
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| tendency to cluster together in more or less elongated groups here
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| and there throughout the area. If we study a group of this type which
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| has been aggregated for a short time we can make out the beginning
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| of a definite plan of organization. Near the axis of the cord delicate
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| fibers appear, produced by the secretory activity of the cells. As this
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| fibrous strand becomes more definite, the cells tend to become ranged
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| against it (Fig. 151, A). In so doing they retract the cytoplasmic
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| processes which are so characteristic of undifferentiated mesenchymal
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| cells and become rounded. In this stage we have essentially a connective tissue in which the fibrous strands are for the most part rather
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| widely separated from one another, and in which each strand has,
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| lined up against it^ the cells responsible for its production.
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| The actual deposition of bone matrix begins very soon after the
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| establishment of these primordial strands of mesenchymal cells and
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| fibers. In fact one usually finds the formation of bone beginning on
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| the older part of a strand while the strand itself is still being extended
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| at one end by the aggregation of more mesenchymal cells (Fig. 151,
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| HISTOGENESIS OF BONE
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| 273
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| I'k;. 151, Formation of trabeculae of membrane bone. Projection drawings from the mandible of a pig embryo 130 mm. in length (cf. Fig. 182).
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| Abbreviations: Matrix cal., ossein matrix impregnated with calcium
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| salts; Matrix oss., ossein matrix not yet impregnated with calcium salts.
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| A). When the mesenchymal cells ranged against the fibrous axis of
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| such a strand become active in the secretion of calcareous material
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| they are spoken of as osteoblasts. We should not lose sight of the fact
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| that they are the same cells which formed the fibrous axis of the
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| original strands, given a new name in deference to their further
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| specialization and altered internal chemistry.
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| In studying the deposition of bone matrix one must bear in mind
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| its dual nature. The matrix consists of an organic fibrous framework
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| which is impregnated by a subsequent deposit of inorganic calcium
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| compounds. We may liken the matrix of bone to reinforced concrete*
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| In the making of a road or a wall, a meshwork of steel is first placed in
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| the forms and concrete is then poured in. The steel gives the finished
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| structure tensile strength and a certain amount of elasticity, the concrete gives form and hardness. So in bone the organic fibers {ossein
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| fibers) impart strength and resilience, while the calcium salts whh
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| which the fibers are impregnated give to the completed matrix body
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| and rigidity.
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| 274 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
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| The two steps in the deposition of bone matrix may be demonstrated readily in areas where active bone forma^tion is going on,
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| owing to the fact that the presence of calcium compounds- in a tissue
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| markedly increases its affinity for stains. Even after most of the calcium salts have been removed from the ossein framework by treatment
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| of the tissue with acids (decalcification) to permit the making of
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| sections, the staining reaction is still apparent. This indicates that
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| the ossein fibers in which calcium has once been deposited are more
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| or less permanently changed chemically even though all the calcium
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| possible is subsequently removed.
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| If we look at a strand on which the osteoblasts have been active
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| for a time (Fig. 151, B) we see, next to the osteoblasts, a zone of bone
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| matrix which takes very little stain. This is the newly deposited
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| organic portion of the matrix as yet unimpregnated with calcium salts.
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| It consists of a feltwork of minute fibers so delicate and so closely
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| matted together that it is very difficult in ordinary preparations to see
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| the individual fibers at all. Slightly farther from the osteoblasts the
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| matrix is densely stained (Fig. 151, B). This part of the matrix has
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| been impregnated with calcium salts, chiefly phosphates and carbonates, and has thereby been converted into true bone matrix. The
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| calcium utilized by the osteoblasts in this process is brought to them
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| by the blood stream where it is carried in soluble form, probably in
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| organic linkage. It is interesting to note in this connection that the
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| presence of calcium and of phosphates in the blood is not in itself all
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| that is necessary for this process. There must be present also sufficient
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| vitamin D, which in some way facilitates the extraction by the osteoblasts of these raw materials from the blood and their deposition in
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| insoluble form as part of the bone matrix. The absence of vitamin D
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| from the system results in the formation of bone matrix deficient in
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| calcium salts and therefore lacking in rigidity — a cohdition not infrequent in pigs. Stock raisers have miscalled this condition rheumatism
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| but it is really the same condition known medically as rickets.
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| In the deposition of the matrix, the fibrous core of the original
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| strand serves as a sort of axis on which the first matrix is laid down.
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| When such a strand is completely invested by bone matrix, it is called
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| a trabecula (little beam). As the osteoblasts continue to secrete and
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| thereby thicken the trabecula, the accumulation of their own product
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| forces them farther and farther away from the axial strand about
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| which the first of the matrix was formed. The new matrix added is
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| not laid down uniformly. It is possible to make out in it markings
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| HISTOGENESIS OF BONE
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| 275
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| which are suggestive of the growth rings of a tree. Apparently the
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| osteoblasts work more or less in cycles, depositing a succession of thin
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| layers of matrix. Each of these layers of the matrix is called a lamella
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| (Fig. 152). As the row of osteoblasts is forced back with the deposit of
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| each succeeding lamella, not all the cells free themselves from their
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| secretion. Here and there a cell is left behind. As its former fellows
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| Erythroblast extruding nucleus
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| Reticular connective-tissue cell j Erythroblast in mitosis
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| Young erythroblast
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| Normoblast
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| Blood vessel .
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| Fat cell --tHemocytoblast —
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| Granuloblast -
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| Hemocytoblast
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| in mitosis
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| Polykaryocyte.
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| :
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| Osteoblast ^ t
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| I
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| Bone cell
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| Bone
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| lamella
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| Fio. 152. A small area of bone and adjacent marrow
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| as seen in highly magnified decalcified sections. The
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| drawing has been schematized somewhat to emphasize
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| the relations of the cytoplasmic processes of the osteoblasts* and the bone cells so important in nutrition. In
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| the adjacent marrow developmental stages of various
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| types ofiiiijioQd cells, have been
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| continue to pile up new matrix, it becomes completely buried (Fig,
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| 151, B). An osteoblast so caught and buried is called a bone cell
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| {osteocyte)^ and the space in the matrix which it occupies is called a | |
| lacuna. The bone cells, thus entrapped, of necessity cease to be active
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| bone formers, but they play a vital part in the maintenance of the
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| bone already formed. They have delicate cytoplasmic processes
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| radiating into the surrounding matrix through minute canalidhli.
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| The processes of one cell come into communication with the processes
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| of its neighbors (Fig. 152). Thus the bone cells nearer to blood vessels
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| 276 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
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| Fig. 153. Diagrams showing stages in establishing of a characteristic area
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| of primary cancellous bone by extension and coalescence of originally
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| separate trabeculae.
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| absorb and hand on materials to their more remote fellows which in
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| turn utilize these materials in maintaining a healthy condition in the
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| organic part of the bone matrix. It is the senescence of these cells with
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| the consequent lowering of their efficiency and the resultant deterioration of the ossein component of the matrix which is in part responsible
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| for the decreased resiliency of the bones in advanced age.
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| As the various trabeculae in an area of developing bone grow,
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| they inevitably come in contact with each other and fuse. Thus
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| trabeculae, at first isolated, soon come to constitute a continuous
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| system (Fig. 153). Because of its resemblance to a latticework (Latin —
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| cancellus), bone in thb condition, where the trabeculae are slender
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| and the spaces between them extensive, is known as cancellous bone.
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| The spaces between the trabeculae are known as marrpw spaces.
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| Endochondral Bone Formation. As the term implies, endochondral bone formation goes on within cartilage. It cannot be stated
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| too strongly that cartilage does not, in this process, become converted
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| int# bone. Cartilage is destroyed and bone is formed where the
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| cartilage used to be. The actual bone formation is essentially the
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| same as in the case of membrane bone. The phenomena of special
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| mSTCXJENESIS OF BONE
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| 277
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| interest in connection with this type of bone development are those
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| involved in the destruction of the cartilage preliminary to the formation of bone.
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| Cartilage Formation. To trace the process logically we must start
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| back with the formation of cartilage. The first indication of impending
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| chondrogenesis is the aggregation of an exceedingly dense mass of
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| mesenchymal cells. This cell mass gradually takes on the shape of the
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| cartilage to be formed. The histogenetic changes involved are not at
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| first conspicuous. During the period of preliminary massing the cells
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| have been migrating in from surrounding regions and also increasing
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| the local congestion by rapid proliferation. As they are packed in
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| together they lose their processes and become rounded (Fig. 154, A,
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| 1). When it seems as if no more cells could possibly be crowded in,
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| the course of events changes. The cells begin to separate from one
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| another. This is due to the fact that they have become active in
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| Fig. 154. Photomicrographs of developing cartilage. The areas photographed were from the margins of the paranasal cartilage of pig embryos
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| between 25 and 30 mm. in length. For location of cartilage in head see
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| figure 175.
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| A, Early stage showing: at (1) the massing of mesenchymal cells which
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| were about to be incorporated in the growing margin of the cartilage; and at
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| (2) an area where matrix formation is already beginning.
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| B, Slightly more advanced stage of the same cartilage showing: at (1)
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| increase in the amount and density of the matrix in the center of the growing
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| cartilage; at (2) concentration of the surrounding mesenchyme to form tire
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| perichondrium; and at (3) the addition of new cartilage matrix peripherally*
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| 278 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
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| | |
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| secreting. It is the accumulation of the secretion of the cells which
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| gradually forces them farther and farther apart unti^ they come to lie
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| isolated from one another in the matrix they have produced (Fig. 1 54,
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| A, 2). Such a method of increase in m^ss, where there are many
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| scattered growth centers contributing independently to the increase
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| in bulk of the whole, is known as interstitial growth. This interstitial
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| growth of young cartilage stands in sharp contrast to the appositional
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| growth of such rigid substances as bone or dentine or enamel where
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| the matrix is laid down in successive layers one upon another. Obviously interstitial growth implies plasticity of the substance produced.
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| Were the substance produced unyielding, the very activity of a number of growth centers within it would soon crowd those growth centers
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| to obliteration.
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| As the cartilage matrix is increased in amount its affinity for basic
| |
| stains becomes more marked, due probably to increase in concentration of the characteristic substance in it known chemically as chondrin.
| |
| At the same time the matrix becomes more rigid with a resultant
| |
| checking of interstitial growth. The cells continue to secrete to a
| |
| certain extent, however, as evidenced by the fact that in mature
| |
| cartilage the matrix immediately surrounding the cells becomes more
| |
| dense than the rest of the matrix. This area of denser matrix around
| |
| the lacuna in which the cell lies is known as the capsule. As the cartilage
| |
| grows older the capsules become more conspicuous and many of
| |
| them come to contain more than one cell. These nests of cells in a
| |
| common capsule are the result of cell divisions, following which the
| |
| daughter cells are held imprisoned in the original capsule of the
| |
| mother cell — further evidence of the loss of plasticity in the matrix.
| |
| | |
| The formation of a matrix so rigid that interstitial growth is
| |
| checked, takes place first centrally in an area of developing cartilage.
| |
| When the center has become too rigid for interstitial growth to continue, appositional growth begins to take place peripherally. While
| |
| the cartilage has been increasing in mass it has been acquiring a
| |
| peripheral investment of compacted mesenchyme. This investing
| |
| layer of mesenchyme soon becomes specialized into a connectivetissue covering called the perichondrium. The layer of the perichondrium next to the cartilage is less fibrous than the outer layer and the
| |
| cells in it continue to proliferate rapidly and become active in the
| |
| secretion of cartilage matrix. For this reason it is known as the
| |
| chondrogenetic layer of the perichondrium. It is through the activity
| |
| (rf the chondrogenetic layer that the cartilage continues to grow
| |
| | |
| | |
| | |
| Cartilage
| |
| | |
| ceil
| |
| | |
| | |
| Cart. trab. 1
| |
| | |
| | |
| | |
| Osteoblast
| |
| | |
| | |
| — Bone
| |
| ntotrix
| |
| | |
| | |
| Bone trabecula
| |
| | |
| | |
| Periosteum
| |
| | |
| | |
| Fig. 155. Drawing showing periosteal bud and an area of endochondral
| |
| bone formation from the radius of a 125 mm. sheep embryo. The small sketch
| |
| indicates the location of the area drawn in detail.
| |
| | |
| Abbreviations: Cart, eros., area from which cartilage has recently been
| |
| eroded; Cart, pre-eros., area with cartilage cells enlarged and arranged in
| |
| rows presaging erosion; Cart, trab,, remnant of cartilage matrix which has
| |
| become calcified and serves as an axis or core about which bone lamellae are
| |
| deposited to form a bone trabecula; Mes., mesenchymal cell.
| |
| | |
| 279
| |
| | |
| | |
| | |
| 280 HISTOGENESIS OF BONE AND DEVEI.OPMENT OF SKELETAL SYSTEM
| |
| | |
| | |
| peripherally, by apposition, long after interstitial growth has ceased
| |
| in the matrix first formed. ^
| |
| | |
| Cartilage Erosion. When a mass of cartilage is about to be replaced by bone, very striking changes in its structure take place. The
| |
| cells which have hitherto been secreting cartilage matrix begin to
| |
| destroy the matrix. The lacunae become enlarged and a curious arrangement of the cartilage cells becomes evident. The cells erode the
| |
| cartilage in such a manner that they become lined up in rows (Fig.
| |
| 155). This process of destruction continues until the cartilage is extensively honeycombed. Meanwhile the tissue of the perichondrium overlying the area of cartilage erosion becomes exceedingly active. There is
| |
| rapid cell proliferation and the new cells, carrying blood vessels with
| |
| them, begin to invade the honeycombed cartilage (Fig. 155).
| |
| | |
| The Deposition of Bone. It is a striking fact that during its growth
| |
| cartilage is devoid of blood vessels, the nearest vessels to it being those
| |
| in the perichondrium. The invasion of cartilage by blood vessels
| |
| definitely determines its disintegration as cartilage, and at the same
| |
| time is the initial step in the formation of bone. For this reason the
| |
| enveloping layer of connective tissue, up to this time called perichondrium because of its relation to the cartilage, is now called
| |
| periosteum because of the relations it will directly acquire to the bone
| |
| about to be formed. This change will not be confusing if we stop to
| |
| think that both these terms are merely ones of relation, which translated mean, respectively, that tissue which surrounds cartilage, and that
| |
| tissue which surrounds bone. The important fact to bear in mind is that
| |
| this enveloping layer of tissue is of mesenchymal origin and therefore
| |
| contains cells of the stock that may develop into any of the connectivetissue family to which bone as well as cartilage belongs. When,
| |
| therefore, a mass of periosteal tissue {periosteal bud, Fig. 155) grows
| |
| into an area of honeycombed cartilage it carries in potentially boneforming cells. These cells come to lie along the strand-like remnants
| |
| of cartilage, just as in membrane bone formation osteoblasts ranged
| |
| themselves along fibrous strands. The actual deposition of bone proceeds in the same manner endochondrally as it does intramembranously. The only difference is that in one case a strand-like remnant of
| |
| cartilage serves as an axis for the trabecula, whereas in the other case
| |
| deposition begins on a fibrous strand. Extensions and fusions of the
| |
| growing trabeculae soon result in the establishment of typical cancellous bone similar to that formed intramembranously.
| |
| | |
| | |
| | |
| HISTOGENESIS OF BONE
| |
| | |
| | |
| 281
| |
| | |
| | |
| The Formation of G)mpact Bone from Primary Cancellous
| |
| Bone. The difference between cancellous bone and compact bone is
| |
| architectural rather than histological. The fundamental composition
| |
| of the bone matrix, its lamellation, and the relations of the bone cells to
| |
| the matrix, are the same in both cases. It is the way in which the
| |
| lamellae are arranged that distinguishes these two types of bone from
| |
| each other. In cancellous bone the disposition of lamellae is such that
| |
| it leaves large marrow spaces between the trabeculae. In compact
| |
| bone there has been a secondary deposit of concentrically arranged
| |
| lamellae in the marrow spaces which greatly increases the density of
| |
| the bone as a whole.
| |
| | |
| The essential differences between the two, and the way in which
| |
| cancellous bone may become converted into compact bone, can be
| |
| illustrated by a simple schematic diagram. Figure 156, 1, shows the
| |
| arrangement of lamellae and marrow spaces in primary cancellous
| |
| bone. The osteoblasts which have formed the trabeculae still lie along
| |
| them on the surface toward the marrow cavity. If such an area is to
| |
| IxTome compact, these osteoblasts enter on a period of renewed
| |
| activity and deposit a series of concentric lamellae in the marrow
| |
| cavity. Frequently if the marrow spaces are irregular there is a
| |
| preliminary rounding out of them by local resorption of the bone
| |
| already formed (Fig. 156, 2). This is then followed by the deposition
| |
| | |
| | |
| | |
| Fig. 156. Diagram showing transformation of cancellous to compact bone.
| |
| The solid lines indicate the lamellae of primary cancellous bone; the dotted
| |
| lines show the subsequently added concentric (Haversian) lamellae which
| |
| nearly obliterate the marrow spaces of cancellous bone. The sequence of
| |
| events is indicated by the numbers. Note that irregularly shaped spaces in
| |
| the cancellous bone may be rounded out by absorption before the concentric
| |
| lamellae are laid down.
| |
| | |
| | |
| | |
| 282 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
| |
| | |
| | |
| of the concentrically arranged lamellae, sometimes called Haversian
| |
| lamellae after the man who first described them in detail (Fig. 156, 3 ).
| |
| In this process the original marrow spaces are reduced to small canals
| |
| {Haversian canals^ into which have been crowded the blood vessels
| |
| which formerly lay in the marrow cavities (Fig. 156, 4 ). These canals
| |
| maintain intercommunication with each other in the substance of the
| |
| bone, constituting a network of pathways over which the bone receives
| |
| its vascular supply. As compared with the marrow spaces of cancellous
| |
| bone, however, they are very small; and the gross appearance of a
| |
| bone which has undergone this secondary deposit of concentric
| |
| lamellae amply justifies characterizing it as ‘'compact.’’
| |
| | |
| II. The Development of the Skeletal System
| |
| | |
| In dealing with the development of the skeletal system we must
| |
| recognize at the outset that the subject is far too extensive to be
| |
| covered here with anything like completeness. It is not difficult, however, to become acquainted with the outstanding features in the
| |
| development of two or three characteristic bones, as, for example:
| |
| the sequence of events in the formation of a flat bone; the steps involved in the establishment and growth of a long bone; the way
| |
| separate ossification centers appear in a common primordial cartilage
| |
| mass and give rise to the various parts of a vertebra. Familiarity with
| |
| such type processes gives one an understanding of the factors operative in the development of the skeleton as a whole and a background
| |
| sufficient to permit ready and intelligent following up of developmental details in specific bones in which one may become interested.
| |
| | |
| Development of Flat Bones. The flat bones, such as the bones
| |
| of the cranium and face, are for the most part of intramembranous
| |
| origin. We are, therefore, already familiar with the early steps in their
| |
| development from our study of the histogenesis of membrane bone
| |
| (Figs. 151 and 153). After a mass of primary cancellous bone has
| |
| been laid down in a configuration which suggests that of the adult
| |
| bone being formed, there appears about this mass a peripheral concentration of mesenchyme (Fig. 157, A). This periosteal concentration
| |
| of mesenchymal tissue contains potentially bone-forming cells which
| |
| soon become active and lay down a dense layer of parallel lamellae
| |
| about the spongy center of the growing bone (Fig. 157, B). Anatomically this dense peripheral portion is known as the outer table of the
| |
| bone. The inner portion, which in the flat bones usually remains
| |
| cancellous, is called the diploii. The original mesenchymal tissue which
| |
| | |
| | |
| | |
| THE DEVELOPMENT OF THE SKELETAL SYSTEM
| |
| | |
| | |
| 283
| |
| | |
| | |
| Periosteum
| |
| Marrow space
| |
| | |
| l^one trabeculae
| |
| | |
| | |
| A
| |
| | |
| Subperiosteal
| |
| bone lamellae
| |
| | |
| | |
| Bone trabeculae
| |
| Marrow space
| |
| | |
| | |
| Periosteum
| |
| | |
| | |
| Fig. 157. Diagrams showing the manner in which the dense peripheral
| |
| layer of a flat bone is formed by the deposition of subperiosteal lamellae about
| |
| an area of primary cancellous bone.
| |
| | |
| I
| |
| | |
| remains in the marrow spaces of the diploe develops into characteristic “red bone marrow†rich in blood-forming elements (Fig. 152).
| |
| | |
| The story of the growth of the mandible, a membrane bone which
| |
| starts after the manner of flat bones but which later takes on a very
| |
| elaborate shape and finally becomes largely compact, can be gleaned
| |
| by a comparative study of figures 178, 180, and 184.
| |
| | |
| Development of Long Bones. The long bones are characteristically of endochondral origin. The cartilage in which they are
| |
| performed is a tempiorary miniature of the adult bone. Ordinarily
| |
| there are several ossification centers involved in the formation of long
| |
| bones. The first one to appiear is that in the shaft or diaphysis. The
| |
| location of this center is shown schematically in figure 158, A, Such
| |
| | |
| | |
| | |
| B
| |
| | |
| | |
| | |
| | |
| 284 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
| |
| | |
| | |
| b
| |
| | |
| A
| |
| | |
| | |
| Fig. 158, Diagrams showing liie progress of ossification in a long bone.
| |
| The stippled areas represent cartilage; the black areas indicate bone.
| |
| | |
| A, Primary ossification center in shaft. B, Primary center plus shell of
| |
| subperiosteal bone. C, Entire shaft ossified. D, Ossification centers have
| |
| appeared in the epiphyses. E, Entire bone ossified except for the epiphyseal
| |
| cartilage plates.
| |
| | |
| details as the cartilage erosion which preceded its appearance and
| |
| the manner in which the deposit of bone was initiated have already
| |
| been considered (Fig. 155). Our interest now is in the relation of such
| |
| an endochondral ossification center to other centers, and to the bone
| |
| as a whole.
| |
| | |
| Almost coincidently with the beginning of bone formation within
| |
| the cartilage the overlying periosteum begins to add bone externally
| |
| (Fig. 158, B). In view of the fact that the bone-forming tissue carried
| |
| into the eroded cartilage arose from the periosteum, this activity of
| |
| the periosteum itself is not surprising. Moreover we have already
| |
| encountered this same phenomenon of periosteal bone formation in
| |
| the outer table of flat bones.
| |
| | |
| The formation of bone which starts at about the middle of the
| |
| shaft soon extends toward either end until the entire shaft is involved
| |
| (Fig. 158, C), leaving the two ends {epiphyses) still cartilage. Toward
| |
| the end of fetal life ossification centers appear in the epiphyses. The
| |
| number and location of these epiphyseal centers vary in different long
| |
| bones. There is always at least one center in each epiphysis and there
| |
| may be two or more. Not uncommonly there are two centers in one
| |
| epiphysis and one in the other, as illustrated in figure 158, D.
| |
| | |
| Between the bone fojcmed in the diaphysis and that formed in the
| |
| epiphysis there persists a mass of cartilage known as the epiphyseal
| |
| plaie which is of vital importance in the growth in length of the bone.
| |
| | |
| | |
| | |
| | |
| | |
| THE DEVELOPMENT OF THE SKELETAL SYSTEM
| |
| | |
| | |
| 285
| |
| | |
| | |
| We should expect from the rigidity of bone matrix that interstitial
| |
| growth could not account for its increase in length. This was long ago
| |
| demonstrated experimentally by exposing a developing bone and
| |
| driving into it three small silver pegs, two in the shaft and one in the
| |
| epiphysis. The distance between the pegs being recorded, the incision
| |
| was closed and development allowed to proceed until a marked
| |
| increase had occurred in the length of the bone. On again exposing
| |
| the pegs, the two in the shaft were found to be exactly the same
| |
| distance apart as when they were driven in, but the distance between
| |
| the pins in the shaft and that in the epiphysis had increased by an
| |
| amount corresponding to the increase in length of the bone. This
| |
| indicates clearly that the epiphyseal plates constitute a sort of temporary, plastic union between the parts of the growing bone. Continued
| |
| increase in the length of the shaft is accomplished by the addition of
| |
| new bone at the cartilage plate. These epiphyseal plates persist during
| |
| the entire postnatal growth period. Only when the skeleton has
| |
| acquired its adult size do they finally become eroded and replaced
| |
| by bone which joins the epiphyses permanently to the diaphysis.
| |
| | |
| As the bone increases in length there is a corresponding increase
| |
| in its diameter. The manner in which this takes place is also susceptible of experimental demonstration. If madder leaves, or some of the
| |
| alizarin compounds extracted from them, be fed to a growing animal,
| |
| the bone formed during the time the feeding is continued is colored
| |
| red. If the madder is discontinued, bone of normal color is again
| |
| formed ; but the color still remains in the bone laid down while madder was being added to the diet. Thus it is possible, by keeping a record
| |
| of alternate f>eriods of feeding and withholding madder and comparing these records with the resulting zones of coloration in a bone, to
| |
| obtain very accurate information on the progress of bone growth and
| |
| resorption. Applied to the development of long bones this method
| |
| shows their increase in diameter to be due to continued appositional
| |
| growth beneath the periosteum. As the bone is added to peripherally
| |
| there is a corresponding resorption centrally. This central resorption
| |
| results in the formation of a cavity in the axis of the long bone which
| |
| is called the marrow canal (Fig. 158, C). With the further increase
| |
| in the diameter of a bone, its marrow canal becomes correspondingly
| |
| enlarged. A significant mechanical fact might be cited in this connection. 'Engineers have determined that the strongest rod which can be
| |
| made from a given weight of steel is obtained by molding it into
| |
| tubular form. The development of an essentially tubular shaft by
| |
| | |
| | |
| | |
| 286 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
| |
| | |
| | |
| progressive increase in the size of the marrow cavity gjivcs a long bone
| |
| maximum strength with minimum weight.
| |
| | |
| The Formation of the Vertebrae. The development of the vertebrae is of interest to the student primarily because it exemplifies so
| |
| excellently a fundamental embryological phenomenon — the origin
| |
| of separate parts from an undifferentiated primordial tissue mass,
| |
| and the subsequent association of these parts to form an organized
| |
| structure. In studying young embryos we traced the history of the
| |
| mesodermic somites through their early differentiation. It will be
| |
| recalled that from the ventro-mesial face of each somite there arises
| |
| a group of mesenchymal cells called collectively a sclerotome (Fig.
| |
| 42). These cells migrate from either side toward the mid-line and
| |
| become aggregated about the notochord. From these masses of cells
| |
| the entire vertebral column is destined to arise.
| |
| | |
| The first significant change which takes place in these primordial
| |
| masses is the clustering of sclerotomal cells derived in part from each
| |
| of the two adjacent somites into groups which are located opposite
| |
| the intervals between the myotomes. In studying series of transverse
| |
| sections this arrangement is easy to overlook unless the density of the
| |
| cells about the notochord is carefully noted in passing from section
| |
| to section. It shows very clearly, however, in frontal sections (Fig. 159).
| |
| Each of these cell clusters is the primordium of the centrum of a vertebra. Once formed they rapidly become more dense and more definitely
| |
| circumscribed (Fig. 160). Soon after the centrum takes shape, paired
| |
| mesenchymal concentrations extending dorsally and laterally from
| |
| the centrum establish the primordia of the neural arches and of the
| |
| ribs (Fig. 161).
| |
| | |
| | |
| | |
| Fig. 159. Semi-schematic coronal sections through the dorsal
| |
| region of young embryos to show how the vertebrae became intermyotomal in position. Note that the primordium of a centrum is
| |
| formed by cells originating from the sclerotomes of both the
| |
| adjacent pairs of somites.
| |
| | |
| | |
| | |
| THE DEVELOPMENT OF THE SKELETAL SYSTEM
| |
| | |
| | |
| 287
| |
| | |
| | |
| | |
| Fig. 160. Transverse section from pig cm])ryo of 17 mm. cut at the level of the
| |
| lungs to show the structures in the dorsal body-wall. (After Minot.)
| |
| | |
| | |
| mantle layer ependymal
| |
| | |
| | |
| marginal layer
| |
| of eord
| |
| | |
| neural arch
| |
| | |
| | |
| of cord
| |
| | |
| | |
| layer
| |
| | |
| | |
| eympathetic ganghon
| |
| anterior cardinal vein
| |
| | |
| | |
| | |
| left left duct
| |
| erihre fetdium vt Ctteter
| |
| | |
| | |
| Fig. 161 . Transverse section of 20 mm. pig embryo cut at the level of the lungs
| |
| to show the developing vertebra and ribs. (After Minot.)
| |
| | |
| | |
| | |
| 288 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
| |
| | |
| | |
| | |
| Fig. 162. Transverse section from 40 mm. pig embryo cut at the level of the
| |
| lungs to show the developing vertebra and ribs.
| |
| | |
| | |
| The Stage in w^hich the various parts of the vertebrae arc sketched
| |
| in mesenchymal concentrations, is frequently spoken of as the blastemal stage. It is rapidly followed by th^ cartilage stage. Conversion to
| |
| cartilage begins in the blastemal mass first in the region of the centrum
| |
| and then chondrification centers appear in each neural and each
| |
| costal process (Fig. 161). These spread rapidly until all the centers
| |
| fuse and the entire mass is involved (Fig. 162). The cartilage miniature of the vertebra thus formed is at first a single piece showing no
| |
| lines of demarcation where the original centers of cartilage formation
| |
| became confluent, and no foreshadowing of the separate parts of
| |
| which it will be made up after the cartilage has been replaced by
| |
| bone. Shortly before ossification begins the rib cartilage becomes
| |
| separated from the vertebra, but the vertebra itself remains in one
| |
| piece throughout the cartilage stage (Fig. 162).
| |
| | |
| The locations of the endochondral ossification centers which
| |
| appear in a vertebral cartilage are indicated schematically in figure
| |
| 163. It readily can be seen how the spreading of these centers of bone
| |
| formation will establish the conditions which exist in an adult vertebra. The median ossification center gives rise to the centrum. The
| |
| centers in the neural processes extend dorsally to complete the neural
| |
| arch. The spinous process in most of the vertebrae is formed by a
| |
| prolongation of these same centers to meet dorsal to the neural canal.
| |
| | |
| | |
| | |
| | |
| Fig. 164. Diagram of four types of vertebrae indicating the parts derived
| |
| from the different ossification centers shown in figure 163. The part formed by
| |
| the median center in centrum is cdncentrically ringed; the parts arising from
| |
| the costal centers are stippled; parts derived from the lateral centers in the
| |
| neural arches are indicated in line-shading,
| |
| | |
| 289
| |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| 290 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
| |
| | |
| | |
| In forms such as the pig the spinous processes of tl>e more anterior
| |
| thoracic vertebrae are very long. In these vertebrae additional ossification centers appear in the spinous process and fuse with those in the
| |
| | |
| Scapula Humerus
| |
| | |
| | |
| | |
| Radius Mandible
| |
| | |
| & ulna
| |
| | |
| | |
| Fig. 165. Photograph (X 1/^ showing the
| |
| ossification centers which have appeared in pig
| |
| embryos of 35 mm. This and the two following
| |
| figures were made by photographing in transmitted light embryos in which all the uncalcified
| |
| tissues had been rendered transparent by treatment with potassium hydroxide and glycerine.
| |
| | |
| neural processes. The transverse processes with which the tubercles
| |
| of the ribs articulate are formed by the lateral extension of the
| |
| primary ossification centers in the neural processes. These same centers
| |
| extend ventrally also, and meet the centrum (cf. Figs. 163 and 164).
| |
| | |
| | |
| Scapula
| |
| / Humerus
| |
| | |
| | |
| | |
| Fic. 166. Photograph (X IM) showing the progress of ossification in the
| |
| skeleton of a 65 mm. pig embryo.
| |
| | |
| | |
| | |
| Fig. 167. Photograph {X showing the extent of ossification in the skeleton of a 90 nun. pig embryo.
| |
| | |
| | |
| | |
| 292 HISTOGENESIS OF BONE AND DEVELOPMENT OF SKELETAL SYSTEM
| |
| | |
| | |
| The shaft of the rib is formed by extension of its primary ossification center (Fig. 163). After birth, secondary epiphyseal centers
| |
| appear in the tubercle and head of the rib. These centers are separated from the shaft by persistent cartilage plates in the manner
| |
| described in discussing the development of long bones. Fusion of the
| |
| secondary epiphyseal centers with the shaft of the rib does not take
| |
| place until the skeleton has acquired its adult dimensions.
| |
| | |
| The foregoing discussion has been based on a thoracic vertebra in
| |
| which the relations of the rib to the vertebra show most clearly.
| |
| All the vertebrae have the costal element represented, although it is
| |
| greatly reduced and modified in other regions than the thoracic. A
| |
| study of figure 164, in which the components of vertebrae from the
| |
| cervical, thoracic, lumbar, and sacral regions are schematically
| |
| indicated, will make the homologies apparent. With these homologies
| |
| in mind it is sufficiently evident, without going into further detail,
| |
| how all these vertebrae arise by a process similar to that described
| |
| for the thoracic vertebrae.
| |
| | |
| The Progress of Ossification in the Skeleton as a Whole. It
| |
| | |
| would carry us beyond the scope of this book to take up the development of specific bones. Each has its own story involving the formation
| |
| of the connective tissue or the cartilage mass which precedes it ; local
| |
| erosion centers if it be preformed in cartilage; number, location, and
| |
| time of appearance of ossification centers; growth in length and
| |
| diameter; development of epiphyses; time of fusion of epiphyses and
| |
| diaphysis; and finally the development of muscle ridges and articular
| |
| facets. Without entering into a discussion of details of this sort, it is
| |
| possible nevertheless to follow the general progress of ossification in
| |
| the skeletal system as a whole. Embryos which have been treated with
| |
| potassium hydroxide and then cleared in glycerine clearly show the
| |
| various ossification centers. In such preparations the areas where
| |
| calcium salts have been deposited stand out white in reflected light
| |
| and opaque in transmitted light. ^Figures 165-167, which are photographs of preparations of this type, can be used to trace the history
| |
| of the more important bones. It should perhaps be stated explicitly
| |
| that these figures arc included primarily to give a general view of the
| |
| progress of ossification and secondarily to afford a readily available
| |
| source of reference for following up points of interest that may arise.
| |
| It is not a profitable use of the student’s time to attempt to memorize
| |
| the ossification centers which have appeared in embryos of any given
| |
| age.
| |
| | |
| | |
| | |
| ==Chapter 13==
| |
| | |
| | |
| Tke Development of tke Face and Jaws
| |
| and tke Teetk
| |
| | |
| | |
| I. The Face and Jaws
| |
| | |
| The Stomodaeum. In studying the early development of the
| |
| digestive tract we saw that the primitive gut first appeared as a
| |
| cavity which was blind at both its anterior and posterior ends (Fig.
| |
| 37). Its opening in the future oral region is established by the meeting
| |
| of an ectodermal depression, the stomodaeum, with the cephalically
| |
| growing anterior end of the gut. The stomodaeal depression, even
| |
| as late as the time the oral plate ruptures and establishes communication between the anterior end of the gut and the outside world, is very
| |
| shallow (Fig. 40). The deep oral cavity characteristic of the adult is
| |
| formed by the forward growth of structures about the margins of the
| |
| stomodaeum. Some idea of the extent of this forward growth can
| |
| be gained from the fact that the tonsillar region of the adult is at
| |
| about the level occupied by the stomodaeal plate when it ruptures.
| |
| The growth of the structures bordering the stomodaeum, then, not
| |
| only gives rise to the superficial parts of the face and jaws, but actually
| |
| builds out the walls of the oral cavity itself.
| |
| | |
| The Jaws. Because the face of a young embryo is pressed against
| |
| the thorax it is difficult to study unless the entire head is cut off and
| |
| mounted separately. Preparations of this kind observed under a dissecting microscope by strong reflected light show the surface configuration of the facial region very clearly. The most conspicuous landmarks
| |
| are the stomodaeal depression, which in view of its fate we may now
| |
| call the oral cavity, and the olfactory pits. In embryos as small as
| |
| 7 mm. most of the structures which take part in the formation of the
| |
| face and jaws are already clearly distinguishable (Fig. 168). In the
| |
| mid-line cephalic to the oral cavity is a rounded overhanging prominence known as the Jrontal process. On either side of the frontal process
| |
| are horseshoe-shaped elevations surrounding the olfactory pits. The
| |
| | |
| 293
| |
| | |
| | |
| | |
| 294
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| median limbs of these elevations are known as the nap-medial processes
| |
| and the lateral limbs are called the naso-lateral processes.
| |
| | |
| Growing toward the mid-line from the cephalo-lateral angles of
| |
| the oral cavity are the maxillary processes. In lateral views of the
| |
| head (Figs. 31 and 32) it will be seen that the maxillary processes
| |
| and the mandibular arch merge with each other at the angles of the
| |
| mouth. Thus the structures which border the oral cavity cephalically
| |
| are: the unpaired frontal process in the mid-line, the paired nasal
| |
| processes on either side of the frontal, and the paired maxillary
| |
| | |
| | |
| | |
| Fig. 168. Face of 7 mm. pig embryo photographed
| |
| X 15. Note especially the unmistakably paired character of the thickenings which later fuse in the mid-line
| |
| to complete the mandibular arch.
| |
| | |
| | |
| processes at the extreme lateral angles. From these primitive tissue
| |
| masses the upper jaw and the nose are derived.
| |
| | |
| The caudal boundary of the oral cavity is less complex, being
| |
| constituted by the mandibular arch alone. In very young embryos
| |
| (Fig. 168) the origin of the mandibular arch from paired primordia
| |
| is still clearly evident. Appearing first on either side of the mid-line
| |
| are marked local thickenings due to the rapid proliferation of mesenchymal tissue. Until these thickenings have extended from either side
| |
| to meet in the mid-line there remains a conspicuous mesial notch.
| |
| With their fusion, the arch of the lower jaw is completed (Figs. 1 69172).
| |
| | |
| | |
| | |
| THE FACE AND JAWS
| |
| | |
| | |
| 295
| |
| | |
| | |
| In 10-12 mm. embryos (Fig. 169) very marked progress can be
| |
| seen in the development of the facial region. The maxillary processes
| |
| are much more prominent and have grown toward the mid-line,
| |
| crowding the nasal processes closer to each other. The nasal processes
| |
| have grown so extensively that the frontal process between them is
| |
| completely overshadowed (cf. Figs. 168 and 169). The growth of the
| |
| | |
| | |
| | |
| Fig. 169. Face of 11 ,5 mm. pig embryo photographed
| |
| X 12. Fusion of the right and left components of the
| |
| mandibular arch is practically complete. Both the
| |
| medial and lateral limbs of the horseshoe-shaped nasal
| |
| processes have undergone conspicuous enlargement.
| |
| Note especially the approximation of each naso-medial
| |
| process to the maxillary process of the same side.
| |
| | |
| | |
| medial limbs of the nasal processes has been especially marked and
| |
| they appear almost in contact with the maxillary processes on either
| |
| side.
| |
| | |
| The groundwork for the formation of the upper jaw is now well
| |
| laid down. Its arch is completed by the fusion of the two nasomedial processes with each other in the mid-line, and with the
| |
| maxillary processes laterally (Fig. 170), The premaxillary bones
| |
| carrying the incisor teeth are formed, later, in the part of the upper
| |
| jaw which is of naso-medial origin. The maxillary bones, carrying all
| |
| | |
| | |
| | |
| 296
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| the upper teeth posterior to the incisors, are developed in the part of
| |
| the arch arising from the maxillary processes.
| |
| | |
| Nasal Chambers. The olfactory pits have by this time become
| |
| much deepened, not only by the growth of the nasal processes about
| |
| them, but also by extension of the original pits themselves which soon
| |
| break through into the oral cavity (Figs. 93 and 97, C). We may now
| |
| | |
| | |
| lateral
| |
| process
| |
| | |
| naso*‘ medial
| |
| process
| |
| | |
| tojngue
| |
| | |
| hyomandibular
| |
| | |
| cleft
| |
| | |
| hyoid arch
| |
| | |
| | |
| Fig. 170. Face of 16 mm. pig embryo photographed X 10. The
| |
| naso-medial processes have fused with the maxillary processes on
| |
| either side, and with each other in the mid-line, thus completing
| |
| the arch of the upper jaw.
| |
| | |
| speak of the external openings of the nasal pits as the nostrils {external
| |
| nares) and their new openings into the oral cavity as posterior nares or
| |
| nasal choanae. The septum of the nose is formed by fusion in the midline of the original naso-medial processes'; the upper part of the
| |
| bridge of the nose is derived from the frontal process; and the alae
| |
| of the nose arise from the naso-lateral processes (Fig. 172).
| |
| | |
| Naao-Iacrimal Duct. Where the naso-lateral process and the
| |
| maxillary process meet each other there is formed iot a time a well
| |
| | |
| | |
| | |
| THE FACE AND JAWS
| |
| | |
| | |
| 297
| |
| | |
| | |
| | |
| Fir;. 171. Face of 17.5 mm. pig embryo photographed X 10. The originally separate processes have now largely lost their identity in the series of
| |
| fusions which have taken place in the formation of the face.
| |
| | |
| | |
| marked groove, which extends to the mesial angle of the eye (Fig. 169).
| |
| This is known as the naso4acrimal groove. It soon closes over superficially (Fig. 171), and it is usually stated that the deep portion of the
| |
| original groove is converted into a tube, the naso-lacrimal duct^ or
| |
| tear duct, wjhich drains the fluid from the conjunctival sac of the eye
| |
| into the nose. Recently Politzer has maintained that the nasolacrimal duct arises as an independent epithelial downgrowth from
| |
| the conjunctival sac which follows closely along the line of closure of
| |
| the old naso-optic furrow.
| |
| | |
| Tongue. While these changes are going on externally, the tongue
| |
| is being formed in the floor of the mouth. Anatomically the tongue is
| |
| usually described as consisting of a freely movable part called its body,
| |
| and a less freely movable portion, called its root, by which it is
| |
| attached in the oro-pharyngeal floor. The body of the tongue arises
| |
| from a small median elevation, the tuberculum impar^ and paired lateral
| |
| lingual primordia. These elevations appear very early in development
| |
| on the inner face of the first branchial (mandibular) arch (Fig. 173,
| |
| B). The tuberculum impar grows slowly and is soon crowded in on
| |
| | |
| | |
| | |
| 298
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| by the more rapidly growing lateral lingual primordia which form
| |
| the great bulk of the body of the tongue (Fig. 173, c5.
| |
| | |
| | |
| | |
| Fig. 172. Face of 21.5 rum. pig embryo
| |
| photographed X 10. The characteristic features
| |
| of the adult face are even at this early stage
| |
| clearly recognizable. The regions of the upper
| |
| jaw and nose which have arisen from originally
| |
| distinct primordia are differentiated by shading.
| |
| Vertical hatching indicates origin from frontal
| |
| process; stippling, from naso-lateral processes;
| |
| small crosses, from naso-medial processes; horizontal hatching, from maxillary processes. The
| |
| entire lower jaw is derived from the mandibular
| |
| arch.
| |
| | |
| | |
| Arising in the pharyngeal floor at the bases of the second and
| |
| third branchial arches is an elevation known as the copula (i.e., yoke)
| |
| | |
| | |
| THE FACE AND JAWS
| |
| | |
| | |
| 299
| |
| | |
| | |
| because of the way it joins these arches together (Fig. 173, B). The
| |
| copula, supplemented by some tissue from the adjacent basal portions of branchial arches 2, 3, and 4, gives rise to the root of the
| |
| tongue.
| |
| | |
| All the various elevations which thus take part in the formation
| |
| | |
| | |
| - Branchial arch i
| |
| | |
| -Branchial arch 2
| |
| | |
| 'Branchial arch 3
| |
| .Branchial arch 4
| |
| -Glottis
| |
| | |
| | |
| Lateral lingual anlagt
| |
| | |
| Copula
| |
| | |
| Epiglottis
| |
| | |
| Glottis
| |
| | |
| | |
| Branchial arch i
| |
| Lateral lingual anlage
| |
| | |
| Branchial arch $
| |
| | |
| Branchial arch 4
| |
| | |
| Arytenoid ridge
| |
| | |
| c
| |
| | |
| Fio. 173. Dissections of pig embryos made to expose the floor of the
| |
| mouth and show the development of the tongue. (After Prentiss.) A, 7 mm.;
| |
| B, 9 mm.; C, 13 mm. (All figures X 12.)
| |
| | |
| | |
| B
| |
| | |
| | |
| | |
| Tuherculum impof
| |
| | |
| Branchial arch 2
| |
| | |
| Epiglottis
| |
| | |
| Glottis
| |
| | |
| | |
| Lateral lingual anlage
| |
| Tuherculum impar
| |
| | |
| Epiglottis
| |
| Arytenoid ridge
| |
| | |
| | |
| Branchial arch i
| |
| Tuherculum impar
| |
| | |
| Branchial arch 2
| |
| | |
| Branchial arch 3
| |
| Branchial arch 4
| |
| | |
| Arytenoid ridge
| |
| | |
| | |
| | |
| 300
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| | |
| THE FACE AND JAWS
| |
| | |
| | |
| 301
| |
| | |
| | |
| of the tongue must be thought of as composed of an outer covering
| |
| and the underlying mesodermal tissue which causes the covering to
| |
| bulge into the lumen. The covering tissue arises in situ from the lining
| |
| of the branchial arches involved. The sensory innervation of the surface of the tongue is, therefore, just what one would expect from the
| |
| basic relations of the cranial nerves to the branchial arches. The
| |
| epithelium of the body of the tongue gets its sensory supply from the
| |
| lingual branch of the mandibular division of the trigeminal (V) nerve
| |
| (Fig. 97, A, B), and from the chorda tympani branch of the seventh
| |
| nerve. The root of the longue receives its sensory fibers from the glossopharyngeal (Fig. 94) and vagus nerves.
| |
| | |
| The skeletal muscle that makes up the main mass of the tongue
| |
| beneath the mucosal covering is derived from mesodermal cell masses
| |
| that are believed to migrate into the pharyngeal floor from the myotomes of the occipital somites. Ontogenetically, in mammalian embryos this migration is exceedingly difficult to trace, for the cells of
| |
| myotomal origin early mingle indistinguishably with the local mesenchymal cells. Nevertheless the way the hypoglossal nerve (XII),
| |
| which is the cranial nerve arising at the level of these occipital myotonies, grows in with the developing lingual muscles (Figs. 93, 94,
| |
| and 97, A, B) and innervates them, furnishes strong circumstantial
| |
| evidence for this interpretation of tongue muscle origin and migration.
| |
| | |
| Palate. Coincidently also the palatal shelf is being formed in the
| |
| upper jaw and separating off the more cephalic portion of the original
| |
| stomodaeal chamber. Since it is into this cephalic portion of the cavity
| |
| that the nasal pits break through (Figs. 93 and 97, C), the formation
| |
| of the palatal shelf in effect prolongs the nasal chambers backwards
| |
| so they open eventually into the region where the oral cavity becomes
| |
| continuous with the pharynx.
| |
| | |
| The palate as well as the arch of the upper jaw is contributed to
| |
| by both the naso-medial processes and the maxillary processes. From
| |
| the premaxillary region a small triangular median portion of the
| |
| palate is formed (Fig. 174). The main portion of the palate is derived
| |
| from the maxillary processes. From them shelf-like outgrowths arise
| |
| | |
| Fig. 1 74. Photographs (X 6) of dissections of pig embryos made to expose
| |
| the roof of the mouth and show the development of the palate. A, 20.5 mm.;
| |
| B, 25 mm.; C, 26.5 mm.; D, 29.5 mm.
| |
| | |
| The diagrams of transverse sections are set in to show the relations before
| |
| (E) and after (F) the retraction of the tongue from between the palatine
| |
| processes.
| |
| | |
| | |
| | |
| | |
| 302
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| on either side and extend toward the mid-line (Fig. 174, A— G). When
| |
| these palatal shelves first start to develop, the tongue lies between
| |
| them (Fig. 174, E). As development progresses the tongue drops down
| |
| (Fig. 174, F); the palatal shelves are extended toward the mid -line
| |
| and finally fuse with each other medially and with the premaxillary
| |
| process anteriorly to complete the palate (Fig. 174, D). At the same
| |
| time the nasal septum grows toward the palate and becomes fused
| |
| to its cephalic face (Figs. 174, F, and 178). Thus the separation of
| |
| | |
| | |
| | |
| | |
| Fig. 175. Transverse section of snout of 28 mm. pig
| |
| embryo (X 12). The area included in the rectangle is
| |
| shown in detail in the following figure.
| |
| | |
| | |
| right and left nasal chambers from each other is accomplished at the
| |
| same time that the nasal region as a whole is separated from the oral.
| |
| | |
| II. The Development of the Teeth
| |
| | |
| The Dental Ledge. Local changes leading toward tooth formation can be made out in the jaws of embryos as small as 1 5 mm. or
| |
| even less. By the time a size of 28-30 mm. has been attained, a definite
| |
| thickening of the oral epithelium can readily be seen on both the
| |
| upper and the lower jaw. This band of epithelial cells which pushes
| |
| into the underlying mesenchyme around the entire arc of each jaw
| |
| is known as the labi<Hlental ledge {labio-dental lamina) (Figs. 175 and
| |
| 176). Shortly after its first appearance, cross-sections show this ledge
| |
| | |
| | |
| | |
| THE DEVELOPMENT OF THE TEETH
| |
| | |
| | |
| 303
| |
| | |
| | |
| of epithelial cells to be differentiating into two parts, a more distal
| |
| part which by its ingrowth marks off the elevation which is to become
| |
| | |
| | |
| | |
| Fig. 176. Drawing (X 130) showing labio-dental ledge of
| |
| 28 mm. pig embryo. For location of area represented see preceding figure.
| |
| | |
| | |
| | |
| Fig. 177. Drawing (X 130) showing differentiation of the
| |
| labio-dental ledge into labio-gingival lamina and dental ledge.
| |
| | |
| The ingrowth of the labio-gingival lamina initiates the separation of the lip from the gum (gingiva). From the dental ledge a
| |
| series of local bud-like outgrowths are formed, each of which
| |
| gives rise to the enamel cap of a tooth.
| |
| | |
| The region shown is the same as that in the preceding figure
| |
| but from a slightly older (37 mm.) embryo.
| |
| | |
| the lip from that which is to become the gum, and a more proximal
| |
| part which is destined to grow into the gum and give rise to the
| |
| enamel-forming organs of the teeth. The part of the original labio
| |
| | |
| | |
| | |
| 304
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| dental ledge which separates the lip from the gum (gingiva) is known
| |
| as the labio-gingival lamina^ and the part of the original ledge which is
| |
| to take part in tooth formation is known as the denial ledge or dental
| |
| lamina (Fig. 177).
| |
| | |
| Enamel Organs. Soon after the dental ledge is established, local
| |
| buds arise from it at each point where a tooth is destined to be formed.
| |
| Since these cell masses give rise to the enamel crown of the tooth they
| |
| are termed enamel organs. As would be expected, the enamel organs
| |
| | |
| | |
| nasal bone
| |
| | |
| | |
| cartilage of
| |
| | |
| nasal septum
| |
| | |
| | |
| nasal
| |
| | |
| chamber
| |
| | |
| | |
| nasal process
| |
| | |
| of premaxilla
| |
| | |
| | |
| | |
| dental papilla
| |
| enamel organ
| |
| | |
| | |
| labiogingival
| |
| | |
| lamina
| |
| | |
| Meckel’s cartilage
| |
| | |
| | |
| tooth germ
| |
| | |
| mandible
| |
| | |
| | |
| Fig. 178. Drawing (X 10)tDf a transverse .section of the snout
| |
| of a 71 mm. pig embryo. The area included in the rectangle is
| |
| shown in detail in the following figure.
| |
| | |
| | |
| for the milk teeth are budded off from the dental ledge first, but the
| |
| cell clusters which later give rise to the enamel of the permanent teeth
| |
| are formed at a surprisingly early time (Fig. 180). They remain
| |
| dormant, however, during the growth period of the milk teeth and
| |
| begin to develop actively only after the jaws have enlarged sufficiently
| |
| to accommodate the permanent dentition.
| |
| | |
| The histogenetic processes involved in the formation of milk teeth
| |
| and permanent teeth are essentially the same. It is, therefore, sufficient
| |
| to trace them in the case of the milk teeth only, keeping in mind that
| |
| the same process is repeated later in life in the formation of the permanent teeth.
| |
| | |
| In a section of the developing mandible which cuts the dental ledge
| |
| | |
| | |
| THE DEVELOPMENT OF THE TEETH
| |
| | |
| | |
| 305
| |
| | |
| | |
| at a point where an enamel organ is being formed, the shape of the
| |
| enamel organ suggests that of an irregularly shaped, inverted goblet,
| |
| the section of the dental ledge appearing somewhat like a distorted
| |
| stem (Fig. 178). The epithelial cells lining the inside of the goblet early
| |
| take on a columnar shape. Because they constitute the layer which
| |
| secretes the enamel cap of the tooth, they are called ameloblasts (enamel
| |
| | |
| | |
| | |
| formers) (Fig. 179). The outer layer of the enamel organ is made up
| |
| of closely packed cells which are at first polyhedral in shape but which
| |
| soon, with the rapid growth of the enamel organ, become flattened.
| |
| They constitute the so-called outer epithelium of the enamel organ (Fig.
| |
| 179). Between the outer epithelium and the ameloblast layer is a
| |
| loosely aggregated mass of ceils called collectively, because of their
| |
| characteristic appearance, the enamel pulp or the stellate reticulum
| |
| (Fig. 179).
| |
| | |
| | |
| 306
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| | |
| Fig. 180. Developing tooth from lower jaw of a 120 mm. pig embryo
| |
| (X 14). The small sketch including half of the tongue (left) and part of the
| |
| lip (right) gives the relations of the region drawn. The area in the rectangle
| |
| is shown in detail in the following figure.
| |
| | |
| | |
| | |
| Fig, 181. Projection drawing (X 350) of segment of enamel organ and
| |
| adjacent pulp from a 120 mm. pig embryo to show ameloblast and odontoblast layers. For location of area represented see preceding figure.
| |
| | |
| | |
| | |
| THE DEVELOPMENT OF THE TEETH
| |
| | |
| | |
| 307
| |
| | |
| | |
| The Dental Papilla. Inside the goblet-shaped enamel organ
| |
| there is caught a mass of mesenchymal cells which are said to constitute the dental papilla (Fig. 179). The cells of the dental papilla
| |
| proliferate rapidly and soon form a very dense aggregation. The outer
| |
| cells of this mass are destined to secrete the dentine of the tooth and
| |
| the inner cells to give rise to the pulp of the tooth.
| |
| | |
| A little later in development the enamel organ begins to assume
| |
| the shape characteristic of the crown of the tooth it is to lay down
| |
| (Fig. 180). At the same time the outer cells of the dental papilla
| |
| take on a columnar form similar to that of the ameloblasts (Fig. 181).
| |
| They are now called odontoblasts (dentine formers) because they are
| |
| about to become active in secreting the dentine of the tooth.
| |
| | |
| In the central portion of the dental papilla vessels and nerves arc
| |
| beginning to make their appearance so that the picture is already
| |
| suggestive of the condition seen in the pulp of an adult tooth. Meanwhile the growth of the dental papilla toward the gum has crowded
| |
| the stellate reticulum of the enamel organ in the crown region so it is
| |
| nearly obliterated (Fig. 180). This brings the ameloblasts of this region
| |
| much closer to the many small blood vessels which lie in the surrounding mesenchyme. The approach of the ameloblasts to the neighboring
| |
| vascular supply would appear to be significant, since it is precisely
| |
| here at the tip of the crown where the ameloblasts first begin to secrete
| |
| enamel (Fig. 182).
| |
| | |
| By the time the enamel organ has been well established the dental
| |
| ledge has lost its connection with the oral epithelium, although traces
| |
| of it can still be identified in the mesenchyme at the lingual side of the
| |
| tooth germ (Fig. 180). The cluster of cells which is destined to give
| |
| rise to the enamel organ of the permanent tooth of this level can be
| |
| seen budding off from the ledge close to the point from which the
| |
| enamel organ of ffie milk tooth arose (Figi >^).
| |
| | |
| Formation of Dentine. With these preparatory developments
| |
| complete, the tooth-forming structures are, so to speak, ready to go
| |
| about the fabrication of dentine and enamel. As is the case with bone,
| |
| enamel and dentine are both composed of an organic basis in which
| |
| inorganic compounds are deposited. We may use the same comparison
| |
| that was used in describing bone : that of the familiar use in construction operations of a steel meshwork into which concrete is poured, the
| |
| steel giving the finished structure some degree of elasticity and increasing the tensile strength while the concrete gives body and solidity.
| |
| In the case of such hard structures in the body as bone, dentine, and
| |
| | |
| | |
| | |
| 308
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND lEETH
| |
| | |
| | |
| pr^ordiutn enamel organ
| |
| ' permanent tooth
| |
| | |
| | |
| odontoblast layer
| |
| pulp of tooth
| |
| | |
| | |
| | |
| enamel pulp (stellate reticulum)
| |
| periosteum of alveolar socket
| |
| outer epithelium of enamel organ
| |
| | |
| | |
| Fig. 182. Developing tooth from lower jaw of a 130 mm. pig embryo
| |
| (X 30). The small sketch gives the relations of the regions drawn. The area
| |
| in the rectangle is shown in detail in the following figure.
| |
| | |
| | |
| blood vessel dentine enamel blood vessel in
| |
| | |
| 1 i, 1 mesenchyme
| |
| | |
| | |
| | |
| fiber lirocess of enamel organ
| |
| | |
| | |
| Fio, 183. Projection drawing (X 350) of small segment of developing
| |
| | |
| | |
| THE DEVELOPMENT OF THE TEETH
| |
| | |
| | |
| 309
| |
| | |
| | |
| enamel, these interlacing organic strands in the matrix give the tissue
| |
| its resilience and tensile strength, and the calcareous compounds
| |
| deposited in the organic framework give form and hardness.
| |
| | |
| Although bone, dentine, and enamel are similar in having both
| |
| organic and inorganic constituents in their matrix they are quite
| |
| different in detail, both as to composition and microscopical structure.
| |
| Bone has approximately 45 per cent of organic material while dentine
| |
| has but 30 per cent and adult enamel 5 per cent or less. There is also
| |
| considerable difference in the kind and proportion of inorganic compounds present in each. Structurally they are totally unlike. Bone
| |
| matrix is formed in lamellae and has cells scattered through it.
| |
| Dentine is formed without lam^llation and has its cellular elements
| |
| lying against one face and sending long processes into tubules in the
| |
| matrix. Enamel is prismatic in structure and the cells which form
| |
| it lie against its outer surface while it is being deposited, but are
| |
| destroyed in the eruption of the tooth.
| |
| | |
| The first dentine is deposited against the inner face of the enamel
| |
| organ, the odontoblasts drawing their raw materials from the small
| |
| vessels in the pulp and secreting their finished product toward the
| |
| enamel organ. It is significant in this connection that in an active
| |
| odontoblast the nucleus, which is the metabolic center of the cell, has
| |
| gravitated toward the source of supplies and come to lie in the extreme
| |
| pulpal end of the cell (Fig, 183). Also, the end of the odontoblast
| |
| toward the enamel organ, where the elaborated product of the cell
| |
| is being accumulated preparatory to its extrusion, can be seen to
| |
| take the stain especially intensely. Although our knowledge of intracellular chemistry is as yet exceedingly fragmentary and we do not
| |
| know the exact chemical nature of the product in this stage, the staining reaction is clearly indicative of the presence of calcium compounds
| |
| of some sort.
| |
| | |
| If attention is turned now to the recently formed dentine, two
| |
| zones distinctly different in staining reaction can be seen. The zone
| |
| nearer the cells is pale, taking but little stain (Fig. 183). This zone
| |
| consists of the recently deposited organic part of the matrix not as yet
| |
| impregnated with calcareous material. The zone nearer the enamel
| |
| organ will be found, by contrast, very intensely stained. This is the
| |
| older part of the dentine matrix which has had the organic framework
| |
| impregnated with calcareous material.
| |
| | |
| As the odontoblasts continue to secrete additional dentine matrix
| |
| the accumulation of their own product inevitably forces the cell
| |
| | |
| | |
| | |
| 310
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| layer back, away from the material previously deposited. Apparently
| |
| strands of their cytoplasm become embedded in the material first laid
| |
| down and are then pulled out to form the characteristic processes of
| |
| the odontoblasts known as the dentinal fibers (Fig. 183). As the layer
| |
| of secreted material becomes thicker and the cells are forced farther
| |
| from the material first deposited, these dentinal fibers become progressively longer. Even in adult teeth where the dentine may be as much
| |
| as 2 mm. in thickness they extend from the odontoblasts which line
| |
| the pulp chamber to the very outer part of the dentine. These dentinal
| |
| fibers are believed to be concerned with maintaining the organic
| |
| portion of the dentine matrix in a healthy condition. When the pulp
| |
| is removed from a tooth, taking with it the odontoblasts, we know
| |
| that the dentine undergoes degenerative changes which involve,
| |
| among other things, increase in brittleness. This would seem to be
| |
| attributable to the degeneration of the organic framework of a matrix
| |
| no longer nourished by the odontoblasts.
| |
| | |
| Formation of Enamel. While the dentine is being laid down by
| |
| the cells of the odontoblast layer, the enamel cap of the tooth is being
| |
| formed by the ameloblast layer of the enamel organ. As was the case
| |
| with the odontoblasts, the active cells of the ameloblast layer are
| |
| columnar in shape and their nuclei, too, lie in the ends of the cells
| |
| toward the source of supplies, in this case the small vessels in the
| |
| adjacent mesenchyme (Fig. 183). The amount of organic material
| |
| laid down as the framework of enamel is much less than is the case
| |
| with either bone or dentine, and it is therefore more difficult to make
| |
| out its precise character and arrangement. It is, nevertheless, possible
| |
| to see in decalcified sections, delicate fibrous strands projecting from
| |
| the tips of the ameloblasts into the areas of newly formed enamel
| |
| (Fig. 183). It seems probable that these strands {Tomes'' processes) are
| |
| in some way involved in the formation of the organic matrix of
| |
| enamel. The problem of tracing the relations of Tomes’ processes to
| |
| the organic framework of enamel is greatly complicated by the fact
| |
| that where the ameloblasts have deposited calcium compounds the
| |
| calcium has rendered the organic part of the matrix so avid in its
| |
| affinity for stains that it is not possible to discern fine structural details
| |
| because of the very density of the resulting coloration (Fig. 183). This
| |
| reaction of the tissue to stains persists even after the inorganic calcium
| |
| compounds have been removed by decalcification, indicating that
| |
| the organic framework itself has been chemically altered by the
| |
| calcium deposited in it.
| |
| | |
| | |
| | |
| THE DEVELOPMENT OF THE TEETH
| |
| | |
| | |
| 311
| |
| | |
| | |
| In spite -of these difficulties in getting at the exact nature and
| |
| arrangement of the organic matrix of enamel, it is quite possible to
| |
| see the genesis of its fundamental prismatic structure. Each amcloblasl
| |
| builds up beneath itself a minute rod or prism of calcareous material.
| |
| These prisms are placed with their long axes approximately at right
| |
| angles to the dento-enamel junction. Collectively these enamel prisms
| |
| form an exceedingly hard cap over the crown of the tooth which in
| |
| its structural arrangement suggests a paving of polygonal bricks laid
| |
| on end. There is sufficient difference in the rate at which the different
| |
| | |
| | |
| growth lines
| |
| | |
| in enamel
| |
| | |
| | |
| pulp chamber
| |
| | |
| growth lines
| |
| in dentine
| |
| | |
| | |
| root canal
| |
| | |
| | |
| cementum
| |
| | |
| | |
| oral epithelium
| |
| | |
| | |
| osteolilasts
| |
| | |
| of periosteum
| |
| of alveolus
| |
| | |
| | |
| connective
| |
| tissue ftbers
| |
| | |
| | |
| cementoblasts
| |
| ( from
| |
| dental sac)
| |
| | |
| | |
| blood vessels
| |
| and nerves to pulp
| |
| | |
| | |
| Fig. 184. Schematic diagram showing the topography of a tooth and its
| |
| relations to the bone of the jaw. The numbered zones indicate empirically
| |
| the sequence of deposition of the dentine and enamel. The so-called growth
| |
| lines in the dentine and enamel follow the general contours indicated by
| |
| the dotted lines in the figure but arc much more numerous.
| |
| | |
| | |
| | |
| 312
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| ameloblasts work so that in actively growing enamel the surface is
| |
| jagged and irregular due to the varying extent to ^<^hich the different
| |
| prismatic elements have been calcified (Fig. 183).
| |
| | |
| Both enamel formation and dentine formation begin at the tip
| |
| of the crown and progress toward the root of the tooth (Figs. 182 and
| |
| 184). But the entire crown is well formed before the root is much more
| |
| than begun. The progressive increase in the length of the root is an
| |
| important factor in the eruption of the tooth, for as the root increases
| |
| in length the previously formed crown must move closer to the surface
| |
| of the gum. Even when the crown of the tooth begins to erupt the
| |
| root is still incomplete, and it does not acquire its full length until the
| |
| crown has entirely emerged.
| |
| | |
| The Formation of Cementum. The so-called cementum of the
| |
| tooth is virtually a bone encrustation of its root. No cementum is
| |
| formed until the tooth has acquired nearly its full growth and its
| |
| definitive position in the jaw. But the first indications of specialization
| |
| in the tissue destined to give rise to it can be seen long before the
| |
| cementum itself appears.
| |
| | |
| Outside the entire tooth germ, between it and the developing bone
| |
| of the jaw, there occurs a definite concentration of mesenchyme.
| |
| The concentration becomes evident first at the base of the dental
| |
| papilla and extends thence crownwards about the developing tooth,
| |
| which it eventually completely surrounds.
| |
| | |
| This mesenchymal investment is known as the dental sac (Fig. 182).
| |
| In the eruption of the tooth the portion of the dental sac over the
| |
| crown is destroyed, but the deeper portion of the sac persists and
| |
| becomes closely applied to the growing root. At about the time the
| |
| tooth has acquired its final position in the jaw, the cells of the dental
| |
| sac begin to form the cementum. Histologically and chemically
| |
| cementum is practically identical with subperiosteal bone. When we
| |
| consider the manner of origin of the dental sac and of the periosteum
| |
| of the bone socket (alveolar socket) in which the root of the tooth lies,
| |
| and see how they arise side by side from the same sort of tissue, this
| |
| seems biit natural. The dental sac is essentially a layer of periosteal
| |
| tissue facing the root of the tooth and back to back with the periosteal
| |
| tissue of the alveolar socket (Fig. 182).
| |
| | |
| The Attachment of Tooth in the Jaw. The attachment of the
| |
| tooth in its socket is brought about by the development, between the
| |
| dental sac and the periosteum of the tooth socket, of an exceedingly
| |
| tough fibrous connective tissue. As the periosteum of the alveolus
| |
| | |
| | |
| | |
| THE DEVELOPMENT OF THE TEETH
| |
| | |
| | |
| 313
| |
| | |
| | |
| adds new lamellae of bone to the jaw on the one side, and the dental
| |
| sac adds lamellae of cementum to the root of the tooth on the other,
| |
| the fibers of this connective tissue are caught in the new lamellae.
| |
| Thus the tooth comes to be supported by fibers which are literally
| |
| calcified into the cementum of the tooth at one end and into the bone
| |
| of the jaw at the other (Fig. 184). The mechanism involved is precisely
| |
| the same as that which occurs in the burying of tendon fibers in a
| |
| growing bone, where the buried ends of the fibers are known as the
| |
| penetrating fibers of Sharpey.
| |
| | |
| Replacement of Deciduous Teeth by Permanent Teeth. The
| |
| | |
| replacement of the temporary or “milk†(deciduous) dentition by the
| |
| permanent teeth is a process which varies in detail for each tooth.
| |
| The general course of events is, however, essentially similar in all
| |
| cases. The enamel organ of the permanent tooth arises from the
| |
| dental ledge near the point of origin of the corresponding deciduous
| |
| tooth (Fig. 180). With the disappearance of the dental ledge, the
| |
| permanent tooth germ comes to lie in a depression of the alveolar
| |
| socket on the lingual side of the developing deciduous tooth (Fig. 185).
| |
| | |
| When the jaws approach their adult size the hitherto latent primordia of the permanent teeth b<-gin to go through the same histo
| |
| | |
| | |
| Fio. 185. Photomicrograph (X 5) of upper jaw of 160 mm. pig embryo
| |
| showing the milk cuspids just breaking through the gum.
| |
| | |
| | |
| 314
| |
| | |
| | |
| DEVELOPMENT OF FACE, JAWS AND TEETH
| |
| | |
| | |
| | |
| Fig. 186. Photomicrograph (X 6) of section through the jaw of a puppy
| |
| showing a deciduous tooth nearly ready to drop out and the developing
| |
| permanent tooth deeply embedded in the jaw below it. The space about the
| |
| crown of the permanent tooth was occupied in the living condition by
| |
| enamel. Fully formed enamel, being approximately 97 per cent inorganic
| |
| in composition, is almost completely destroyed by the decalcification with
| |
| acids which must be carried out before such material can be sectioned.
| |
| (From a preparation loaned by Dr* S. W. Chase.)
| |
| | |
| | |
| THE DEVELOPMENT OF THE TEETH
| |
| | |
| | |
| 315
| |
| | |
| | |
| genetic changes we have already traced in the case of the temporary
| |
| teeth. As the permanent tooth increases in size, the root of the deciduous tooth is resorbed and the permanent tooth comes to lie underneath
| |
| its remaining portion (Fig. 186). Eventually nearly the entire root
| |
| of the deciduous tooth- is destroyed and its loosened crown drops out,
| |
| making way for the eruption of the corresponding permanent tooth.
| |
| | |
| | |
| | |
| | |
| BiLlio grapky
| |
| | |
| | |
| Although this docs not purport to be a complete bibliography
| |
| on the development of the pig, I have tried to make it comprehensive.
| |
| At least one reference has been included on every phase of the subject
| |
| concerning which I could find published information. Under each
| |
| of the main subject headings some of the articles referred to have
| |
| extensive bibliographies of the literature in their special field. But,
| |
| with the exception of a few outstanding contributions, no papers have
| |
| been included which are merely of historical interest. For such articles
| |
| reference should be made to the exhaustive bibliographies compiled
| |
| by Minot (1893) and by Keibel (1897). Furthermore, the list is largely
| |
| restricted to contributions based directly on pig embryos. Exception
| |
| to this rule has been made in favor of a few general articles which
| |
| are of especial assistance in acquiring a perspective on some phase of
| |
| the subject. Also, a number of articles based on other forms have been
| |
| included when no work appeared to have been done on corresponding
| |
| phases of development in the pig. It is hoped that such a list of
| |
| selected references will furnish a starting point for following up any
| |
| desired line of inquiry without involving one in a discouraging
| |
| multiplicity of titles.
| |
| | |
| Texts and Manuals
| |
| | |
| Arey^ L. i?., 19^6. Developmental Anatomy. Saunders, Philadelphia, 5th Ed., ix &
| |
| | |
| 616 pp.
| |
| | |
| Baumgartner, W, J,, 1924, Laboratory Manual of the Foetal Pig, Macmillan, New
| |
| York, vii & 57 pp.
| |
| | |
| Boyden, E. A., 1936. A Laboratory Atlas of the 13-mm. Pig Embryo. (Prefaced by
| |
| younger stages of the chick embryo.) The Wistar Institute Press, Philadelphia,
| |
| iv & 104 pp.
| |
| | |
| Hamilton, W. J., Boyd, J. D., and Mossman, H. W., 1945. Human Embryology.
| |
| | |
| Williams and Wilkins, Baltimore, viii & 366 pp.
| |
| | |
| Hertwig, O., 1901-07. Handbuch der Vergleichenden und experimentellen Entwicklungslehre der Wirbeltiere. (Edited by Dr. Oskar Hertwig and written by
| |
| numerous collaborators.) Fischer, Jena.
| |
| | |
| Huettner, A, F., 1941. Fundamentals of Comparative Embryology of the Vertebrates.
| |
| Macmillan, New York, xiv & 416 pp,
| |
| | |
| Jordan, H. E,, and Kindred, J. E., 1948. A Textbook of Embryology. Appleton, New
| |
| York, 5th Ed., xiv & 613 pp.
| |
| | |
| | |
| 317
| |
| | |
| | |
| | |
| | |
| 318
| |
| | |
| | |
| BIBLIOGRAPHY
| |
| | |
| | |
| Keihel^ F., 1897. Normentafeln zur Entwicklungsgeschichte der Wirbelthiere. I. Des
| |
| Schweines. Fischer, Jena, 114 S.
| |
| | |
| Martin^ P., 1912. Lehrbuch der Anatomic der Haustiere. ^chickhard & Ebner,
| |
| Stuttgart. (Bd. 1, Allgemeine und vergleichende Anatomic mit Entwicklungsgeschichte, xii & 811 S.)
| |
| | |
| Minot ^ C, S., 1893. A Bibliography of Vertebrate Embryology. Memoirs, Boston
| |
| Soc. Nat. History, Vol. 4, pp. 487-614.
| |
| | |
| Mtnot, C, S., 1911. A Laboratory Textbook of Embryology. The Blakiston Company,
| |
| Philadelphia, 2nd Ed., xii & 402 pp.
| |
| | |
| Needham^ J'., 1931. Chemical Embryology. Macmillan, New York, xxii & 2021 pp.
| |
| | |
| Patten^ B. A/., 1929. Early Embryology of the Chick. The Blakiston Company, Philadelphia, 3rd Ed., xiii & 228 pp.
| |
| | |
| Patten, B. M., 1946. Human Embryology. The Blakiston Company, Philadelphia,
| |
| XV & 776 pp.
| |
| | |
| Stssori, S., 1921. The Anatomy of the Domestic Animals. Saunders, Philadelphia,
| |
| 2nd Ed., 930 pp.
| |
| | |
| Wetss, P.y 1939. Principles of Development. A Text in Experimental Embryology.
| |
| Holt, New York, xix & 601 pp.
| |
| | |
| IVieman, H. L., 1930. An Introduction to Vertebrate Embryology. McGraw-Hill,
| |
| New York, xi & 411 pp,
| |
| | |
| Windle, W, F., 1940. Physiology of the Fetus. Saunders, Philadelphia, xiii & 249 pp.
| |
| | |
| Zeitzschmann, 0,, 1923-24. Lehrbuch dcr Entwicklungsgeschichte der Haustiere.
| |
| R. Schoetz, Berlin, 542 S,
| |
| | |
| General Articles and Articles of Significance for the
| |
| Interpretation of Developmental Processes
| |
| | |
| Alexander, J., 1944. The Gene — A Structure of Colloidal Dimensions. Chapt. 37,
| |
| pp. 808-819, in “Colloid Chemistry,†Vol. V, edited by Jerome Alexander,
| |
| Reinhold Publishing Corp., New York.
| |
| | |
| Allen, W. F., 1918. Advantages of sagittal sections of pig embryos for a medical
| |
| embryology course. Anat. Rec., Vol. 14, pp. 183-191.
| |
| | |
| Barth, L. G., 1944. Colloid Chemistry in Embryonic Development. Chapt. 39, pp.
| |
| 851-859, in “Colloid Chemistry,†Vol. V, edited by Jerome Alexander, Reinhold Publishing Corp., New York.
| |
| | |
| Chambers, R., 1944. Some Physical Properties of Protoplasm. Chapt. 41, pp. 864-875,
| |
| in “Colloid Chemistry,†Vol. V, edited by Jerome Alexander, Reinhold
| |
| Publishing Corp., New York.
| |
| | |
| Conklin, E, G., 1914. The cellular basis of heredity and development. Pop. Sci.
| |
| Monthly, Vol. 85, pp. 105-133. '
| |
| | |
| Hartman, C. G., 1 931 . Development of the egg as seen by the physiologist. Sci. Monthly,
| |
| Vol, 33, pp, 17-28.
| |
| | |
| Medley, 0. F., 1926. Quantitative study of growth of certain organs in pig fetus. Bull.
| |
| Med. Coll. Va., Vol. 23, pp. 19-36.
| |
| | |
| Holtfreter, J., 1947. Changes of structure and the kinetics of differentiating embryonic
| |
| cells. Jour. Morph., Vol. 80, pp. 57-92.
| |
| | |
| Holtfreter, J., 1947. Observations on the migration, aggregation and phagocytosis of
| |
| embryonic cells. Jour. Morph., Vol. 80, pp. 93-111.
| |
| | |
| | |
| | |
| THE SEX ORGANS AND GAMETOGENESIS
| |
| | |
|
| |
|
| 319
| | [[Category:Draft]] |
| | |
| | |
| Kingsbury, B. F,, 1926. On the so-called law of anteroposterior development. Anat.
| |
| Rec., Vol. 33, pp. 73-87.
| |
| | |
| Lewis, W, H., 1947. Mechanics of invagination. Anat. Rec., Vol. 97, pp. 139-156.
| |
| | |
| Spemann, H., 1927. Organizers in animal development. Proc. Roy. Soc. London,
| |
| Ser. B, Vol. 102, pp. 177-187.
| |
| | |
| Spemann, H., 1938. Embryonic Development and Induction. Yale Univ. Press,
| |
| New Haven, xii & 401 pp.
| |
| | |
| The Sex Organs and Gametogenesis
| |
| | |
| Allen, E., 1923. Ovogenesis during sexual maturity. Am. Jour. Anat., Vol. 31, pp.
| |
| 439-481.
| |
| | |
| Allen, E., Kountz, IV. B., and Francis, B. F., 1925. Selective elimination of ova in the
| |
| adult ovary. Am. Jour. Anat., Vol. 34, pp. 445-468.
| |
| | |
| Bascom, K. F., 1925. Quantitative studies of the testis. I. Some observations on the
| |
| cryptorchid testes of sheep and swine. Anat. Rec., Vol. 30, pp. 225-241.
| |
| | |
| Bascom, K. F., and Ouerud, H. L., 1925. Quantitative studies of the testicle. II. Pattern
| |
| and total tubule length in the testicles of certain common mammals. Anat. Rec.,
| |
| Vol. 31, pp. 159-169.
| |
| | |
| Blandau, R. J., 1945. The first maturation division of the rat ovum. Anat. Rec.,
| |
| Vol. 92, pp. 449-457.
| |
| | |
| Corner, G. W., 1917. Maturation of the ovum in swine. Anat. Rec., Vol. 13, pp. 109
| |
| 112 .
| |
| | |
| Comer, G. IV., 1919. On the origin of the corpus luteum of the sow from both granulosa and theca interna. Am. Jour. Anat., Vol. 26, pp. 117-183.
| |
| | |
| Evans, H. M., and Swezv, 0., 1929. Ovogenesis and the normal follicular cycle in adult
| |
| mammalia. Mem. LTniv. Cal., Vol. 9, pp. 119-224.
| |
| | |
| Everett, N. B., 1945. The present status of the germ-cell problem in vertebrates. Biol.
| |
| Rev., Vol. 20, pp. 45-55.
| |
| | |
| Gould, H. N., 1923. Observations on the genital organs of a sex intergrade hog. Anat.
| |
| Rec., Vol. 26, pp, 241-261.
| |
| | |
| Hargitt, G. T., 1925-30, The formation of the sex glands and germ cells of mammals.
| |
| Jour. Morph. & Physiol., Vols. 40, 41, 42, 49.
| |
| | |
| Hartman, C. G., 1926. Polynuclear ova and polyovular follicles in the opossum and
| |
| other mammals, with special reference to the problem of fecundity. Am. Jour.
| |
| Anat., Vol. 37, pp. 1-52.
| |
| | |
| Hill, R. T., Allen, E., and Kramer, T. C., 1935. Cinemicrographic studies of rabbit
| |
| ovulation. Anat. Rec., Vol. 63, pp. 239-245.
| |
| | |
| Kellicott, W. E,, 1913. A Textbook of General Embryology. Holt, New York, v &
| |
| 376 pp.
| |
| | |
| Kiipfer, M., 1920. Beitrage zur Morphologic der weiblichen Geschlechtsorgane bei
| |
| den Saugetieren. Ueber das Auftreten gelber Korper am Ovarium des domestizierten Rindes und Schweines. Vierteljahrsschrift d. Naturf. Gesellsch., Zurich,
| |
| Bd. 65, S. 377-433.
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| Carey, E. J., 1921. Studies in the dynamics of histogenesis. VT. Resistances to skeletal
| |
| growth as stimuli to chondrogenesis and osteogenesis. Am. Jour. Anat., Vol. 29,
| |
| pp. 93-115.
| |
| | |
| Carey, E. J., 1922d. Studies in the dynamics of histogenesis. Intermittent traction and
| |
| contraction of differential growth, as a stimulus to myogenesis. XI. The dynamics of the pectoralis major muscle tendon. Anat. Rec., Vol. 24, pp. 89-96.
| |
| | |
| Carey, E. J., 1922b. Direct observations on the transformation of the mesenchyme in
| |
| the thigh of the pig embryo (Sus scrofa), with especial reference to the genesis
| |
| of the thigh muscles, of the knee- and hip-joints, and of the primary bone of the
| |
| femur. Jour. Morph., Vol. 37, pp. 1-77.
| |
| | |
| Glucksmann, A., 1939. Studies on bone mechanics in vitro. II. The r61e of tension and
| |
| pressure in chondrogenesis. Anat. Rec., Vol. 73, pp. 39-55.
| |
| | |
| Godlewskt, E., 1902. Die Entwicklung des Skelet- und Herzmuskelgewebes der Saugethiere. Arch. f. rnikr. Anat. u. Entwg., Bd. 60, S. 111-156.
| |
| | |
| Hanson, F. B., 1*91 9a. The ontogeny and phylogeny of the sternum. Am. Jour. Anat.,
| |
| Vol. 26, pp. 41-115.
| |
| | |
| Hanson, F. B., 1919b. The development of the sternum in Sus scrofa. Anat. Rec.,
| |
| Vol. 17, pp. 1-23.
| |
| | |
| Hanson, F. B., 1920. The development of the shoulder-girdle of Sus scrofa. Anat. Rec.,
| |
| Vol. 18. pp. 1-21.
| |
| | |
| Huber, E., 1931. Evolution of Facial Musculature and Facial Expression. The Johns
| |
| Hopkins Press, Baltimore, xii & 184 pp.
| |
| | |
| Ingalls, T, H,, 1941. Epiphyseal growth: Normal sequence of events at the epiphyseal
| |
| plate. Endocrinology, Vol. 29, pp. 710-719.
| |
| | |
| Isaacs, R., 1919. The structure and mechanics of developing connective tissue. Anat.
| |
| Rec., Vol. 17, pp. 243-270.
| |
| | |
| Kibrick, E, A., Becks, H, Marx, W., and Evans, H, M., 1941. The effect of different
| |
| dose levels of growth hormone on the tibia of young hypophysectomized female
| |
| rats. Growth, Vol. 4, pp. 437-447.
| |
| | |
| | |
| | |
| 338
| |
| | |
| | |
| BIBLIOGRAPHY
| |
| | |
| | |
| Kingsbury^ B. F., 1920, The developmental origin of the notochord. Science, Vol. 51,
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| |
| | |
| Lacroix, F., 1945. On the origin of the diaphysis. Anat. Rec., Vol. 92, pp. 433-439.
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| | |
| McGill, C., 1907-08. The histogenesis of smooth muscle in the alimentary canal and
| |
| respiratory tract of the pig. Internat. Monatschr. f. Anat. u. Physiol., Bd. 24,
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| S. 209-245.
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| | |
| McGill, C., 1910. The early histogenesis of striated muscle in the oesophagus of the
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| pig and the dogfish. Anat. Rec., Vol. 4, pp. 23-47.
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| | |
| Mead, C. S,, 1909. The chondrocranium of an embryo pig, Sus scrofa. A contribution
| |
| to the morphology of the mammalian skull. Am. Jour. Anat., Vol. 9, pp. 167-210.
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| Murray, P. D. F., 1936. Bones. A Study of the Development and Structure of the
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| Vertebrate Skeleton. Cambridge Univ. Press, London, x & 203 pp.
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| JVauck, E. T., 1926. Entwicklung des Schultergelenkes beim Schwein; Wachsplattenmodelle (als Ergazung zum Vortrag fiber das Coracoideum der Sauger).
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| Verhandl. Anat. Ges., Bd. 35, S. 260-261.
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| Parker, W. K., 1874. On the structure and development of the skull of the pig. Phil.
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| Trans. Roy. Soc. London, Ser. B, Vol. 164, pp. 289-336.
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| Ruth, E. B., 1932. A study of the development of the mammalian pelvis. Anat. Rec.,
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| Vol. 53, pp. 201-225.
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| Sawin, P. B., 1945. Morphogenetic studies of the rabbit. 1. Regional specificity of
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| hereditary factors affecting homoeotic variations in the axial skeleton. Jour,
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| Exp. Zool., Vol. 100, pp. 301-329.
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| | |
| Sawtn, P. B., 1946. Morphogenetic studies of the rabbit. III. Skeletal variations resulting from the interaction of gene determined growth forces. Anat. Rec., Vol.
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| 96, pp. 183-200.
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| | |
| Shields, R. T., 1923. On the development of tendon sheaths. Carnegie Inst., Contrib.
| |
| to Embryo!., Vol. 15, pp. 53-61.
| |
| | |
| Silberberg, M., and Silberberg, R., 1946. Fufther investigations on the effect of the male
| |
| sex hormone on endochondral ossification. Anat. Rec., Vol. 95, pp. 97-117.
| |
| | |
| Stearns, M. L., 1940. Studies on the development of connective tissue in transparent
| |
| chambers in the rabbit’s ear. Part I, Am. Jour. Anat., Vol. 66, pp. 133-176;
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| Part II, Am. Jour. Anat., Vol. 67, pp. 55-97.
| |
| | |
| Warkany, J., and Nelson, R. C., 1942. Skeletal abnormalities induced in rats by maternal nutritional deficiency. Arch. Path., Vol. 34, pp. 375-384.
| |
| | |
| Weed, I. G., 1936. Cytological studies of developing muscle with special reference to
| |
| myofibrils, mitochondria, Golgi material and nuclei. Zeitschr. f. Zellforsch. u.
| |
| mikr. Anat., Bd. 25, S. 516-540.
| |
| | |
| Williams, L. W., 1908. The later development of the notochord in mammals. Am.
| |
| Jour. Anat., Vol. 8, pp. 251-284.,
| |
| | |
| Teeth, Hair, and Hoofs
| |
| | |
| Adlof, P., 1901. Zur Entwickelungsgeschichtc des Zahnsystems von Sus scrofa domest.
| |
| Anat. Anz., Bd, 19, S. 481-490.
| |
| | |
| Beams, H. W., and King, R. L., 1933. The Golgi apparatus in the developing tooth,
| |
| with special reference to polarity. Anat. Rec., Vol. 57, pp. 29-39.
| |
| | |
| Bevelander, G., 1941. The development and structure of the fiber system of dentin.
| |
| Anat. Rec., Vol, 81, pp. 79-97.
| |
| | |
| | |
| | |
| TWINS, DOUBLE MONSTERS, ANOMALIES
| |
| | |
| | |
| 339
| |
| | |
| | |
| Bevelander, G., and Johnson^ P. L., 1945. The histochemical localization of alkaline
| |
| phosphatase in the developing tooth. Jour. Cell. & Comp. Physiol., Vol. 26,
| |
| pp. 25-33.
| |
| | |
| Bevel andei ^ G.^ and Johnson^ P. T., 1946. The histochemical localization of glycogen in
| |
| the developing tooth. Jour. Cell. & Comp. Physiol,, Vol. 28, pp, 129-137.
| |
| | |
| Bild^ T., 1902. Die Entwickelungsgeschithte des Zahnsystems bei Sus domesticus und
| |
| das Verhaltnis der Lippenfurchenanlage zur Zahnleiste. Anat. Anz., Bd, 20, S.
| |
| 401-410.
| |
| | |
| Chase, S, W., 1932. Histogenesis of the enamel. Jour. Am. Dental Assn., Vol. 19, pp.
| |
| 1275-1289.
| |
| | |
| Glasstone, S., 1935. The development of tooth germs in vitro. Jour. Anat., Vol. 70,
| |
| | |
| pp. 260-266.
| |
| | |
| Ilampp, E. G., 1940. Mineral distribution in the developing tooth. Anat. Rec., Vol.
| |
| 77, pp. 273-291.
| |
| | |
| Held, //., 1926. Uber die Bildung des Schmelzgewebes. Zeitschr. f. mikr. Anat. P'orsch.,
| |
| Bd. 5, S. 668-687.
| |
| | |
| Ihrsch, M., 1921. Der Liickzahn von Sus domesticus, ein Beitrag zur Entwicklungsgeschichte des Gebisses von Sus domesticus und zur Kenntnis des Wesens der
| |
| Dentitionen. Anat. Anz., Bd. 54, S. 321-330.
| |
| | |
| Jasswom, G., 1924. Uber die Histogencse der Dentingrundsubstanz der Saugetiere.
| |
| Arch. f. mikr. Anat., Bd. 102, S. 291-310.
| |
| | |
| Morse, A , and Creep, R. 0 , 1947. Alkaline glycerophosphatase in the developing
| |
| teeth of the rat. Its localization and activity characteristics as influenced by pH
| |
| of the substiate and length of incubation time. Anat. Rec., Vol. 99, pp. 379-395.
| |
| | |
| Rein, G , 1882. Untersuchungen iiber embryonale Entwicklungsge.schichte der Milchdriise. Arch. f. mikr. Anat., Bd. 20, S. 431-501 und Bd. 21, S. 678-694
| |
| | |
| Saundeis, J, B, de C, M., Nuckolls, J., and Ftisbie, H. F., 1942. Amelogenesis. A histologic study of the development, formation and calcification of the enamel in the
| |
| molar tooth of the rat. Jour. Am, Coll. Dentists, Vol. 9, pp. 107-136.
| |
| | |
| Schmidt, V,, 1925. Studien fiber die Histogencse der Haut und ihrer Anhangsgebilde
| |
| bei Saugetieren und beim Menschen. I. Die Histogencse des Hufes bei Schweineembryonen. Zeitschr, f. mikr. Anat. Forsch., Bd. 3, S. 500-557.
| |
| | |
| Schour, /., and Steadman, S. R., 1935. The growth pattern and daily rhythm of the
| |
| incisor of the rat. Anat. Rec., Vol. 63, pp. 325-333.
| |
| | |
| Schultze, O., 1892. Ueber die erste Anlagc des Milchdrfisenapparates. Anat. Anz.,
| |
| Bd. 7, S. 265-270.
| |
| | |
| Thoms, H., 1896. Untersuchungen fiber Bau, Wachsthum und Entwicklung des Hufes
| |
| der Artiodactylen, insbesondere des Sus scrofa. Deutsche Thieraerzliche Wochenschr., Jahrgang. 4, S. 379-383.
| |
| | |
| Z^itzschmann, 0., 1924. Die Entwicklung des Systems der ausseren Haut. (b) Die
| |
| Haare. (Schwein.) Lehrbuch der Entwicklungsgcschichte der Haustierc, S.
| |
| 186-194.
| |
| | |
| Twins, Double Monsters, Anomalies
| |
| | |
| Baumgartner, W, J,, 1928. A double monster pig — Cephalothoracopagus monosymmetros. Anat. Rec., Vol. 37, pp. 303-316.
| |
| | |
| Berge, S,, 1941. The inheritance of paralysed hind legs, scrotal hernia and atresia ani
| |
| in pigs. Jour. Heredity, Vol. 32, pp. 271-274.
| |
| | |
| | |
| | |
| 340
| |
| | |
| | |
| BIBLIOGRAPHY
| |
| | |
| | |
| Bishopy Af., 1921. The nervous system of a two-headed pig embryo. Jour. Comp.
| |
| Neur., Vol. 32, pp. 379-428.
| |
| | |
| Bishops M., 1923. The arterial system of a two-headed pig embfyo. Anat. Rec., Vol.
| |
| 26, pp. 205-222.
| |
| | |
| Carey, E,, 1917. The anatomy of a double pig, Syncephalus thoracopagus, with
| |
| especial consideration of the genetic significance of the circulatory apparatus.
| |
| Anat. Rec., Vol. 12, pp. 177-192.
| |
| | |
| Chidester, F. /?., 1914. Cyclopia in mammals. Anal. Rec., Vol. 8, pp. 355-366.
| |
| | |
| Cornel, G, W., 1921. Abnormalities of the mammalian embryo occurring before implantation. Carnegie Inst., Contrib. to Embryol., Vol. 13, pp. 61-66.
| |
| | |
| Corner, G. W., 1922. The morphological theory of monochorionic twins as illustrated
| |
| by a series of supposed early twin embryos of the pig. Bull. Johns Hopkins Hosp.,
| |
| Vol. 33, pp. 389-392.
| |
| | |
| Corner, G. W., 1923. The problem of embryonic pathology of mammals with observations upon intra-uterine mortality in the pig. Am. Jour. Anat., Vol. 31, pp.
| |
| 523-545.
| |
| | |
| Denison, H., 1908. Notes on pathological changes found in the embryo pig and its
| |
| membranes. Anat. Rec., Vol. 2, pp. 253-256.
| |
| | |
| Dutta, S. K., 1930. Notes on the cyclopian eye and other deformities of the head in a
| |
| pig. (Sus cristatus Wagn.) Allahabad Univ. Studies, Sci. Sec., Vol. 7, pp. 53-103.
| |
| | |
| Fitzpatrick, F, L,, 1928. The dissection of an abnormally developed foetal pig, with
| |
| notes on the possible origins of such “freaks.†Proc. Iowa Acad. Sci., Vol. 35,
| |
| pp. 319-325.
| |
| | |
| Hughes, W., 1927. Sex-intergrades in foetal pigs. Biol. Bull., Vol. 52, pp. 121-136.
| |
| | |
| Jordan, H. E., Davis, J. S., and Blackford, S. D., 1923. The operation of a factor of
| |
| spatial relationship in mammalian development, as illustrated by a case of
| |
| quadruplex larynx and triplicate mandible in a duplicate pig monster. Anat.
| |
| Rec., Vol. 26, pp. 311-318.
| |
| | |
| Kingsbury, B, F., 1909. Report of a case of hermaphroditism (H. Verus lateralis) in
| |
| Sus scrofa. Anat. Rec., pp. 278-281.
| |
| | |
| Nordby, J. E., 1929. Congenitad skin, ear, and skull defects in a pig. Anat. Rec., Vol.
| |
| 42, pp. 267-280.
| |
| | |
| Poklman, A, G., 1919. Double ureters in human and pig embryos. Anat. Rec., Vol.
| |
| 15, pp. 369-373.
| |
| | |
| Schwalbe, E., 1906-1913. Die Morphologic dcr Missbildungen des Menschen und der
| |
| Tiere. Fischer, Jena, Vol. 1, xvi & 230 pp., Vol. 2, xx & 410 pp., Vol. 3, Abt. 1,
| |
| 270 pp., Abt. 2, 858 pp., Anhang, 266 pp.
| |
| | |
| Streeter, G. L., 1924. Single-ovum twins in the pig. Am. Jour. Anat., Vol. 34, pp.
| |
| 183-194.
| |
| | |
| Thuringer, J, M,, 1919. The anatomy of a diccphalic pig (Monosomus diprosopus).
| |
| Anat. Rec., Vol. 15, pp. 359-367.
| |
| | |
| JVarkany, J., and Roth, C, B., 1948. Congenital malformations induced in rats by
| |
| maternal vitamin A deficiency. II. Effect of varying the preparatory diet upon
| |
| the yield of abnormal young. Jour. Nutrition, Vol. 35, pp* 1-11.
| |
| | |
| Williams, S. R., and Rauch, R. W., 1917. The anatomy of a double pig (Syncephalus
| |
| thoracopagus). Anat. Rec., Vol. 13, pp. 273-280.
| |
| | |
| | |
| | |
| Index
| |
| | |
| | |
| To facilitate the use of this book in connection with otheis in which the terminology
| |
| may differ somewhat, many synonyms which were not used in the text have been put into
| |
| the index and cross-referenced to the alternative terms used in this book; for example,
| |
| Wolffian body, a teim not used in this text, is frequently applied to the mesonephros. It
| |
| appears m the index thus: Wolffian body (= mesonephros, q.v.).
| |
| | |
| Both figure and page references are given in the index. The figure references arc preceded by the letter /.
| |
| | |
| | |
| Abdominal pregnancy, 217
| |
| Abducens nerve, 169
| |
| Accessory nerve, 172
| |
| Acoustic ganglion, /92, 117, 169
| |
| Acoustico-facialis ganglion ( = early undifferentiated condition of ganglia of
| |
| 7th and 8th cranial nerves), 169
| |
| Action system, 141
| |
| | |
| Adrenal, /1 00, /106, /1 27, /1 28, /1 38, 223
| |
| After-birth, 105
| |
| Alae of nose, 296
| |
| Alar plate of neural tube, 1 57
| |
| Allantois, circulation of, /45,/51, 99
| |
| formation of,/30,/37, 99
| |
| function of, 106
| |
| relations of,/49,/55, 103
| |
| Alveolar periosteum, 312
| |
| Ameloblasts,/179-183, 305, 310
| |
| Amnion, formation of,/25,/37,/50, 97
| |
| function ofi 96
| |
| relations of,/49, 97
| |
| Amniotes, 96
| |
| Amniotic folds, 97
| |
| Ampulla of ductus deferens, /3, 8
| |
| Anal plate ( = cloacal plate, q.v.)
| |
| Anamniotes, 96
| |
| Angioblast, 87 footnote
| |
| Animad pole, 37
| |
| | |
| Anterior intestinal portal, /37, 74
| |
| Anterior neuropore, /29, 71
| |
| Anus,/118,/132, 210, 225
| |
| Aorta, see arteries
| |
| Aortic arches, sec arteries
| |
| Aortic bulb, 256
| |
| Aortic chromaffin body, 223
| |
| Appendage buds, /3 1-34, 65, 109
| |
| | |
| | |
| Appendix, of epididymis, /1 24, 213
| |
| of testis, /1 24, 217
| |
| Appositional growth, 278
| |
| Aqueduct of Sylvius, 158
| |
| Archenteron, 43
| |
| Areola, 105
| |
| | |
| Arterial circle (of Willis), 131
| |
| Arteries, allantoic, /45,/51, 89, 132, 240
| |
| aorta, dorsal, /67, /1 33-1 37, 88, 131,
| |
| 235, 240
| |
| | |
| aoita, ventral, /45, /1 33, 88, 235
| |
| aortic arches, /45, /1 33-1 37, 88, 129,
| |
| | |
| 233
| |
| | |
| basilar, /66, /67, /133, /137, 131, 238
| |
| brarhio-cephalic,/133, 234
| |
| carotid, common, /1 33, /1 37, 234
| |
| carotid, external, /67, /1 33, /1 37, 130,
| |
| | |
| 234
| |
| | |
| carotid, internal, /66, /133, /137, 130,
| |
| 234, 238
| |
| caudal, 240
| |
| | |
| cervical, intersegmental,/66,/133,/l37,
| |
| 130, 235
| |
| | |
| coeIiac,/67,/lll, 132, 240
| |
| ductus arteriosus /1 33, /ISO, 235, 262,
| |
| 268
| |
| | |
| hypogastric, 240, 270
| |
| iliacs,/66, /150, 240
| |
| innominate, 234
| |
| internal mammary, 238
| |
| interscgmcntal,/67,/133, 130, 235
| |
| mesenteric, ant., /67, /1 11, 132, 238
| |
| mesenteric, post»,/lll, 238
| |
| omphalomesenteric, /45, 89, 131, 238
| |
| pulmonary, /67, /1 33-1 37, 130, 234,
| |
| 267
| |
| | |
| | |
| 341
| |
| | |
| | |
| | |
| 342
| |
| | |
| | |
| INDEX
| |
| | |
| | |
| Arteries — {Continued)
| |
| | |
| renal, /1 27, /1 28, 240
| |
| speimatic, /1 27-1 30
| |
| | |
| subclavian, /67, /133-135, 131, 234,
| |
| 235
| |
| | |
| umbilical (allantoic), /66, /1 50, 89, 132,
| |
| 240
| |
| | |
| vertebral,/66,/67,/137, 131, 237
| |
| vitelline, /45, 89, 132
| |
| Arytenoid process of larynx, /1 38
| |
| Astrocytes, 150
| |
| Atresia of ovarian follicles, 20
| |
| Atrio-ventricular canal, 126, 256
| |
| Atrium, 126, 254
| |
| | |
| Auditory, ganglion, see acoustic nerve, 1 69
| |
| vesicle, /36,/61, 117, 169
| |
| | |
| Basal plate of neural tube,/91, 157
| |
| Belly-stalk, /49, 97
| |
| Bicornate uterus, 216
| |
| Bile duct, common, 185
| |
| Bladder (urinary), /118, /124, /125, /130,
| |
| 209
| |
| | |
| Blastocoele, j\S, 41
| |
| Blastocyst, /1 7, 41
| |
| | |
| elongation of, /1 8, 45
| |
| riastodermic vesicle ( == blastocyst, q.v.)
| |
| Blastodisc ( — embryonic disc, q.v.)
| |
| Blastorneie, 38
| |
| Blastula, 41
| |
| | |
| Blood cells, formation of,/48,/152, 90, 251
| |
| Blood islands, /48, 89, 251
| |
| Blood vessels, formation of, /48, 87
| |
| see also arteries and veins
| |
| Body axis, 60
| |
| Body cavity, see coelom
| |
| Body folds, /38, 72
| |
| Body-stalk, sec belly-stalk
| |
| Bone, cancellous, 272
| |
| cells, /1 51, /1 52, 275
| |
| compact, 272
| |
| endochondral, 272
| |
| histogenesis of, 271
| |
| intramembranous, 272
| |
| lacuna, 275
| |
| lamellae, /1 51, 275
| |
| marrow, /1 52, 251
| |
| matrix, /1 51, 273
| |
| trabeculae, /1 51, /1 53, 274
| |
| Bone, formation of,
| |
| | |
| compact from cancellous, 281
| |
| | |
| | |
| Bone — '{Continued)
| |
| | |
| endochondral, /1 55, 276
| |
| flat, /1 57, 282 '
| |
| | |
| intramem branous, /1 5 1 , /1 53, 272
| |
| long, /1 58, 283
| |
| | |
| primary cancellous, /1 51, /153, 272,
| |
| 281
| |
| | |
| Bowman’s capsule, /1 16, 203
| |
| Brachial plexus, 116
| |
| Brain, formation of, /36, 69
| |
| neuromeric structure of, 69
| |
| regional differentiation of,/87, 1 S4
| |
| ventricles of, /88, 156, 160
| |
| 3-vesicle stage, /36, 70
| |
| 5-vesicle stage, /60, 110
| |
| Branchial arches (= gill arches, q.v.)
| |
| | |
| Bridge of nose, 296
| |
| | |
| Broad ligaments of uterus, 222
| |
| | |
| Bronchi, 189
| |
| | |
| Bulbo-urethral gland, /3, /1 24, 9, 213
| |
| | |
| Clalcification
| |
| | |
| of bone, 274
| |
| of teeth, 309
| |
| | |
| Calyces of renal pelvis, /1 19
| |
| Canal, atrio-ventncular, 126
| |
| Haversian, /1 56, 282
| |
| inguinal, /1 29, 222
| |
| of Gartner, 217
| |
| pleural,/! 10
| |
| pleuro- peritoneal, 195
| |
| semicircular, 169
| |
| Canalicuii, /152
| |
| Cancellous bone, /1 53, 276
| |
| Capsule, glomerular, /1 21, 203
| |
| of Bowman, /1 21 , 203
| |
| of cartilage cells, 278
| |
| Cardiac loop, /1 42, 125, 254
| |
| Cardinal vessels, see veins
| |
| “Cartilage bone,†272
| |
| Cartilage, erosion, /1 55, 280
| |
| formation, /1 54, 277
| |
| matrix, 278
| |
| Caval plica, /1 40, 245
| |
| Cecum, /102, 122, 182
| |
| Cementoblasts, /1 84
| |
| Cemcntum,/184, 312
| |
| Central canal of spinal cord,/86, 151
| |
| Centrum, see vertebrae
| |
| Cephalic region, differentiation of, 61
| |
| mesoderm of, 1 91
| |
| | |
| | |
| | |
| INDEX
| |
| | |
| | |
| 343
| |
| | |
| | |
| Cephalic region — (Continued)
| |
| precocity of, 54
| |
| Cerebellar peduncles, 157
| |
| Cerebellum, /80,/87, 157
| |
| Cerebral aqueduct, 158
| |
| Cerebral cortex, 145, 162
| |
| Cerebral ganglia, see ganglia, cranial
| |
| Cerebral hemispheres, /87, 162
| |
| Cerebral peduncles, /1 00, 158
| |
| Cerebro-spinal paths, 142
| |
| Cervical flexure, 66
| |
| Cervical sinus, /32, /1 69, 109
| |
| Cervix of uterus, 216
| |
| Choanae, of nose, 296
| |
| Chondrin, 278
| |
| Chondrogenesis, 276
| |
| Chondrogenctic layer, 278
| |
| Chorda dorsalis ( = notochord, q.v.)
| |
| | |
| Chorion, /55-57, 103
| |
| Chorionic vesicle, /54, 103
| |
| Chorionic villi, /57
| |
| Choroid fissure, of eye,/39, 117
| |
| Choroid plexus, anterior (of 3rd ventricle),
| |
| /106, 158, 162
| |
| | |
| lateral (of 1st and 2nd ventricles), /1 00.
| |
| | |
| 162
| |
| | |
| posterior (of 4th ventricle), /65, /99,
| |
| /1 38, 156
| |
| | |
| Chromaffin tissue, 223
| |
| Chromosomes, sex, 23
| |
| species number of, 21
| |
| Circle of Willis, /1 33, 131
| |
| Circulation, changes in at birth, 268
| |
| early embryonic, /45,/51, 92
| |
| hepatic portal, 241
| |
| interpreta^tion of embryonic, 227
| |
| placental,/45,/51,/55, 93, 263
| |
| pulmonary, 262, 267
| |
| vitelline, /45, /1 41, 93, 249
| |
| Circulatory arcs, 92
| |
| Cleavage, /1 2, /1 3, /1 4, 37
| |
| Cleavage cavity, see blastococle
| |
| aitoris,/132, 225
| |
| Cloaca, /65, /1 18, 120, 209
| |
| Cloacal plate (membrane), /37, 209
| |
| Cochlea, 169
| |
| Coelom, /1 09
| |
| | |
| abdominal, /1 11, 194
| |
| diflferentiation of, /1 08, 193
| |
| formation of,y20, f22,/108, 51, 120, 189
| |
| intra- and extra-embryonic, 52, 190
| |
| | |
| | |
| Coelom — (Continued)
| |
| | |
| partitioning of, /1 11-1 13, 194
| |
| pericardial, /26, /44, /1 09, /1 10, /111,
| |
| 53, 87, 195
| |
| peritoneal, /1 10, 189
| |
| pleural,/! 11, /1 13, 194
| |
| thoracic, 194
| |
| | |
| Colliculi, inferior, suptTior (lobes of corpora
| |
| quadngemma), /80, /87, 157, 167
| |
| Colon (large intestine), /1 02, 182
| |
| Columns of spinal cord, /8 6, 154
| |
| Commissural ganglion, /92, 172
| |
| Components of spinal nerve, 151
| |
| Concrescence, /20, 46
| |
| Coordinating centers, 145
| |
| Copula, /41
| |
| Cord, spinal, 71, 115
| |
| | |
| and reflexes, /80, 142
| |
| histogenesis of, /8 1-8 3, 147
| |
| white and grey matter of,/86, 151
| |
| Cord, umbilical, 250
| |
| Corona radiata, 18
| |
| Coronary sinus, sec veins
| |
| Corpora quadrigemma, /87, 157
| |
| Corpus albicans, 27
| |
| Corpus hacmorrhagicurn, 26
| |
| Corpus luteum, formation of,/6, 24
| |
| in pregnancy, /1 0, 26
| |
| significance of, 33
| |
| Corpus striatum, 1 63
| |
| | |
| Cowper’s gland (= bulbo-urethral gland,
| |
| q.v.)
| |
| | |
| Cranial flexure, 66
| |
| | |
| Cranial ganglia, see ganglia
| |
| | |
| Cranial nerves, see nerves
| |
| | |
| Crura cerebri (= cerebral peduncles, q.v.)
| |
| | |
| Cumulus oophorus, 19
| |
| | |
| Cutis plate, see dermatome
| |
| | |
| Cystic duct,/104,/105, 184
| |
| | |
| Decalcification, 274
| |
| Deciduous placenta, 103
| |
| Deitcr’s nucleus, /80, 144
| |
| Dental ledge, /1 75-1 80, 302
| |
| Dental papilla, 307
| |
| Dental sac, /1 82, 312
| |
| Dentinal fiber /1 83, 310
| |
| Dentine, /1 83, 307
| |
| Dermatome, /42, 81
| |
| | |
| Deutoplasm, effect of on cleavage, /1 2, 37
| |
| in pig ovum, 39
| |
| | |
| | |
| | |
| 344
| |
| | |
| | |
| INDEX
| |
| | |
| | |
| Diaphragm, /1 00, /1 12, 194
| |
| Diaphragmatic ligament of mesonephros,
| |
| /1 23, 218
| |
| | |
| Diaphysis, of long bone, 283
| |
| Dicnccphalon, /60, 110, 158
| |
| Diestrum, 29
| |
| | |
| Diocoele ( =« lumen of diencephalon)
| |
| Dio-mesencephalic boundary, 110
| |
| Dio-telcncephalic boundary, 110
| |
| Diploe, of bone, 282
| |
| Diploid number of chromosomes, 22
| |
| Dorsal, aorta, see arteries
| |
| flexure, 66
| |
| | |
| mesentery, /1 08, /1 11, 192
| |
| mesocardium,/43,/144, 87, 254
| |
| nerve roots, see nerves, spinal
| |
| root ganglia, see ganglia, spinal
| |
| Duct of, Cuvier ( = common cardinal
| |
| vein, q.v.)
| |
| | |
| Santorini, 186
| |
| Wirsung, 186
| |
| | |
| Ductus, arteriosus, /1 33, /1 38, /1 50, 235,
| |
| 262, 268
| |
| | |
| choledochus ( = common bile duct, q.v.)
| |
| deferens, /3, /1 18, /1 24, 9, 213
| |
| endolymphaticus, 117
| |
| venosus, see veins
| |
| Duodenum, /1 00, /1 02, 184
| |
| | |
| Ear, external, /33,/34, 62
| |
| internal, 62, 117, 169
| |
| middle, 118, 170
| |
| Ectoderm, 59, 98
| |
| | |
| derivatives of,/27
| |
| Efferent ductules, 213
| |
| Egg nests, 1 5
| |
| | |
| Ejaculatory duct, /3, /1 24, 9, 213
| |
| Embryonic disk, /1 6, /1 9, 45, 60
| |
| Enamel, /183, 310
| |
| Enamel organ, /1 79-1 82, 303
| |
| Enamel prisms, 311
| |
| | |
| Endocardial cushion of A-V. canal, /39,
| |
| /147,/148, 126, 256
| |
| Endocardial cushion tissue, 256
| |
| Endocardial primordia,/43,/44, 85
| |
| Endocardium, 85
| |
| Endolymphatic duct, 117
| |
| Endothelium, origin of vascular, /48, 87
| |
| Entoderm, 59
| |
| | |
| derivatives of, /27
| |
| formation of, /1 6, 43
| |
| | |
| | |
| Eparterial bronchus, /1 07
| |
| Ep>endymal cells, 150
| |
| Ependymal layer of c^d,/81, 147
| |
| Epicardium, 85
| |
| | |
| Epididymis, /3, /1 24, /1 29, 213
| |
| | |
| Epi-myocardium,/43,/44, 85
| |
| | |
| Epiphyseal cartilage plates, 284
| |
| | |
| Epiphyseal ossification centers, 284
| |
| | |
| Epiphyses of long bones, /1 58, 284
| |
| | |
| Epiphysis, of diencephalon, /1 06, 110, 158
| |
| | |
| Epiploic foramen, 181
| |
| | |
| Epo6phoron,/125, 217
| |
| | |
| Equation division, 22
| |
| | |
| Erythroblasts, /1 52
| |
| | |
| Esophagus, /64,/72, 80, 119, 179
| |
| | |
| Estrus, 29
| |
| | |
| Estrus cycle, /9, 29
| |
| | |
| Eustachian tube, 118, 175
| |
| | |
| Evolution, 198, 229
| |
| | |
| Exocoelom, 52
| |
| | |
| Extra-embryonic coelom, see coelom
| |
| Extra-embryonic membranes, /49, 94
| |
| Eye, 63, 116, 167
| |
| | |
| Face, development of, /1 68-1 72, 293
| |
| Facial nerve, /92, 169
| |
| Falciform ligament, /1 1 1 , 193
| |
| Fallopian tube (= uterine tube, q.v.)
| |
| Fasciculi, see columns of spinal cord
| |
| Fertilization, /1 1, 34
| |
| Flexion, 65, 107
| |
| Floor plate of neural tube, 156
| |
| Fetal membranes, see extra-embryonic
| |
| membranes
| |
| | |
| Follicle, ovarian, /6,/7, 17
| |
| Foramen, ovale, 260, 267, 268 see also
| |
| interatrial
| |
| | |
| Foramen of Monro, /88, /1 38, 160
| |
| Foramen of Winslow, 181
| |
| Fore-brain, see prosencephalon
| |
| Fore-gut, /26,/37, 74
| |
| Fossa ovalis, 269
| |
| | |
| Fovea cardiaca (= ant. intestinal portal,
| |
| q.v.)
| |
| | |
| Frontal lobe, 163
| |
| | |
| Frontal process, /1 68-1 72, 293
| |
| | |
| Froriep’s ganglion, /92, 172
| |
| | |
| Gall-bladder, /46, /103-105, /1 40, 80, 119,
| |
| 184
| |
| | |
| Gametes, /8, 9, 12, 15
| |
| | |
| | |
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| {{Footer}}
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