BGDB Sexual Differentiation - Early Embryo: Difference between revisions
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Several different defects in both sexes can occur if this septation process is not correctly aligned (rectourethral fistula, rectovaginal fistula). | Several different defects in both sexes can occur if this septation process is not correctly aligned (rectourethral fistula, rectovaginal fistula). | ||
[[File:Stage12_sem9_cloacal_membrane.jpg|300px]] | |||
Cloacal Membrane (intact) | |||
(week 4 [[Carnegie stage 12]]) | |||
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Revision as of 11:40, 3 June 2013
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio |
Week 4 to 5
<mediaplayer width='550' height='580' image="http://embryology.med.unsw.edu.au/embryology/images/4/46/Stage13-GIT-icon.jpg">File:Stage13 GIT3d.mp4</mediaplayer> | Begin by observing the internal structure of the embryo at the end of week 4 and the beginning of week 5.
Colour code:
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Mesonephros and Mesonephric Duct
Section 29-46: (E1-G4) Section passes dorsally to the mesonephros. Return to G4 and then follow the caudal route of the mesonephric duct into the sacral region.
29 (E1L) | 30 (E2L) | 31 (E3L) | 32 (E4L) | 33 (E5L) | 34 (E6L) | 35 (E7L) |
36 (F1L) | 37 (F2L) | 38 (F3L) | 39 (F4L) | 40 (F5L) | 41 (F6L) | 42 (F7L) |
43 (G1L) | 44 (G2L) | 45 (G3L) | 46 (G4L) |
Kidney and Mesonephric Duct
<mediaplayer width='360' height='500' image="http://embryology.med.unsw.edu.au/embryology/images/f/fe/Urogenital_sinus_001_icon.jpg">File:Urogenital_sinus_001.mp4</mediaplayer> | Now go back and observe the development of the intermediate mesoderm.
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Primitive Urogenital Sinus
<mediaplayer width='420' height='415' image="http://embryology.med.unsw.edu.au/embryology/images/8/88/Urogenital_septum_001_icon.jpg">File:Urogenital_septum_001.mp4</mediaplayer> | Stages in septation of the urogenital sinus between Week 4 and 6.
Several different defects in both sexes can occur if this septation process is not correctly aligned (rectourethral fistula, rectovaginal fistula). Cloacal Membrane (intact) (week 4 Carnegie stage 12) |
Gonad Development
Male Testis
<mediaplayer width='350' height='650' image="http://embryology.med.unsw.edu.au/embryology/images/f/fa/Gonad-icon.jpg">File:Testis 001.mp4</mediaplayer> | Development of the male gonad showing medullary sex cords.
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Female Ovary
<mediaplayer width='350' height='650' image="http://embryology.med.unsw.edu.au/embryology/images/f/fa/Gonad-icon.jpg">File:Ovary_001.mp4</mediaplayer> | Development of the female gonad showing medullary sex cords.
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Gonadal Development Comparison
Now directly compare the development of the male and female gonad (click image to start, these may not be synchronised).
Gonad-icon.jpg</wikiflv> | Gonad-icon.jpg</wikiflv> |
Ovary | Testis |
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio |
Additional Information
The following figures are from a recent review of Sex determination and gonadal development in mammals.[1]
- Signaling in genital development
- Sex reversal in humans caused by abnormal X-Y exchange
- Structure of the early fetal testis
- Mesonephric tubules in the 11.5 dpc mouse urogenital ridge
- Development and differentiation of the genital duct system
- The migratory pathway of primordial germ cells
- Structure of the early fetal testis
- Differentiation of pre-Sertoli cells into Sertoli cells
- Model for cell-autonomous and prostaglandin-mediated upregulation of Sox9 in pre-Sertoli cells
- Visualization of testicular cell types
- Postulated molecular pathway leading to the formation of the bipotential genital ridge
- Structure of mouse and human SRY protein
- Postulated interaction of molecular players involved in early testicular development
References
- ↑ <pubmed>17237341</pubmed>| Physiol. Rev.
Nussey S, Whitehead S. Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers; 2001. Chapter 6 The gonad
BGDB: Lecture - Gastrointestinal System | Practical - Gastrointestinal System | Lecture - Face and Ear | Practical - Face and Ear | Lecture - Endocrine | Lecture - Sexual Differentiation | Practical - Sexual Differentiation | Tutorial
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Cite this page: Hill, M.A. (2024, April 26) Embryology BGDB Sexual Differentiation - Early Embryo. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/BGDB_Sexual_Differentiation_-_Early_Embryo
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G