ACPS Seminar 2014 - Implantation

Understanding Implantation and the new Uterine Tube Biobank Tuesday 18th March 6.00pm - Level 4 Seminar Space, Lowy Cancer Research Centre, Building C25 Kensington Campus, UNSW

Dr Mark Hill

Human Development - Week 1

<mediaplayer width='500' height='450' image="http://embryology.med.unsw.edu.au/embryology/images/0/07/Human_blastocyst_day_1-5.jpg">File:Human_blastocyst_day_3-6.mp4</mediaplayer> morula to blastocyst

Human Development - Week 2

<mediaplayer width='250' height='260' image="http://php.med.unsw.edu.au/embryology/images/a/a9/Week2_001_icon.jpg">File:Week2_001.mp4</mediaplayer>

This animation shows the process of implantation, occurring during week 2 (GA week 4) of development in humans. The beginning of the animation shows adplantation to the the uterus lining (endometrium epithelium). The hatched blastocyst with a flat outer layer of trophoblast cells (green), the inner cell mass which has formed into the bilaminar embryo (epiblast and hypoblast) and the large fluid-filled space (blastocoel). green cells - trophoblast layer of the conceptus blue cells - epiblast layer of the bilaminar embryo yellow cells - hypoblast layer of the bilaminar embryo white cells - uterine endometrium epithelium red - maternal blood vessel

Early Implantation

Implantation Signaling	Compartment colours
	purple - epithelium at the attachment site pink - luminal epithelium orange - glandular epithelium blue - stroma

Ectopic Implantation

<mediaplayer width='660' height='540' image="http://php.med.unsw.edu.au/embryology/images/f/f0/Ectopic_01.jpg">File:Ectopic_01.mp4</mediaplayer>

Movie shows the most common form of ectopic pregnancies, those that occur with premature implantation in the uterine or fallopian tubes, a tubal pregnancy. The movie shows an ectopic embryo (less than 10 weeks gestation) which has implanted in the left uterine tube. RT - Normal Right Tube, the movie starts by showing the normal right uterine tube. LT - Ectopic Left Tube, the scan then moves to the left uterine tube (LT) where ectopic implantation has occurred. L OV - Also visible is the left ovary UT - uterus.

Ectopic GA Week 7	Ectopic GA Week 10
	Image: Dr Steven O'Connor (Houston, Texas) - Other embryo images.

First trimester placental villi	Term placental villi

Tube Biobank

Tube Analysis Techniques

Protein Expression

mRNA Expression

Immune Protection

HLA-G - Human leukocyte antigen G (HLA-G, HLA-6.0; HLA60, T-CELL A LOCUS; TCA)

• Expression by fetal cells protects from immune rejection.
• HLA-G is a non-classical HLA class-Ib molecule expressed by the extravillous cytotrophoblasts (EVT) of the placenta.
• 338 AA protein, mRNA differential splicing gives rise to 7 isoforms: 4 membrane-bound forms (HLA-G1, G2, G3, G4) and 3 soluble forms (sHLA-G5, G6, G7)

HLA-G expression (red) on trophoblast cell columns (CC) and extravillous trophoblasts.

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

• Australian Centre for Perinatal Science
• UNSW Biobank

References

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Cite this page: Hill, M.A. (2024, May 2) Embryology ACPS Seminar 2014 - Implantation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/ACPS_Seminar_2014_-_Implantation

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G