ACPS Seminar 2014 - Implantation

Understanding Implantation and the new Uterine Tube Biobank Tuesday 18th March 6.00pm - Level 4 Seminar Space, Lowy Cancer Research Centre, Building C25 Kensington Campus, UNSW

Dr Mark Hill

Human Development - Week 1

<mediaplayer width='500' height='450' image="http://embryology.med.unsw.edu.au/embryology/images/0/07/Human_blastocyst_day_1-5.jpg">File:Human_blastocyst_day_3-6.mp4</mediaplayer> morula to blastocyst

Human Development - Week 2

<mediaplayer width='250' height='260' image="http://php.med.unsw.edu.au/embryology/images/a/a9/Week2_001_icon.jpg">File:Week2_001.mp4</mediaplayer>

This animation shows the process of implantation, occurring during week 2 (GA week 4) of development in humans. The beginning of the animation shows adplantation to the the uterus lining (endometrium epithelium). The hatched blastocyst with a flat outer layer of trophoblast cells (green), the inner cell mass which has formed into the bilaminar embryo (epiblast and hypoblast) and the large fluid-filled space (blastocoel). green cells - trophoblast layer of the conceptus blue cells - epiblast layer of the bilaminar embryo yellow cells - hypoblast layer of the bilaminar embryo white cells - uterine endometrium epithelium red - maternal blood vessel

Tube Biobank

Tube Analysis Techniques

Protein Expression

mRNA Expression

Immune Protection

HLA-G - Human leukocyte antigen G (HLA-G, HLA-6.0; HLA60, T-CELL A LOCUS; TCA)

• Expression by feral cells protects from immune rejection.
• HLA-G is a non-classical HLA class-Ib molecule expressed by the extravillous cytotrophoblasts (EVT) of the placenta.
• 338 AA protein, mRNA differential splicing gives rise to 7 isoforms: 4 membrane-bound forms (HLA-G1, G2, G3, G4) and 3 soluble forms (sHLA-G5, G6, G7)

HLA-G expression (red) on trophoblast cell columns (CC) and extravillous trophoblasts and not seen for syncitiotrophoblast (SYN) cells.

External Links

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• Australian Centre for Perinatal Science
• UNSW Biobank

References

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Cite this page: Hill, M.A. (2024, May 2) Embryology ACPS Seminar 2014 - Implantation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/ACPS_Seminar_2014_-_Implantation

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G