Prostate Development
Introduction
The male and female reproductive systems develop initially "indifferently", it is the product of the Y chromosome SRY gene that makes the "difference". The mesonephric duct (Wolffian Duct) contributes the majority of male internal genital tract. The embryonic gonad development leads to the mesonephric/paramesonephric duct changes, while the external genitaila remain indeterminate in appearance through to the fetal period. Importantly its sex chromosome dependence, late embryonic/fetal differential development, complex morphogenic changes, long time-course, hormonal sensitivity and hormonal influences make it a system prone to many different abnormalities.
The prostate gland is generally recognised due to its late postnatal adult growth changes, rather than its embryonic development, and the health effects of prostate cancer.
There are also currently separate pages describing Spermatozoa Development | Testis Development | Prostate Development.
| Puberty
Some Recent Findings
|
Textbooks
- Human Embryology (2nd ed.) Larson Chapter 10 p261-306
- The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Chapter 13 p303-346
- Before We Are Born (5th ed.) Moore and Persaud Chapter 14 p289-326
- Essentials of Human Embryology, Larson Chapter 10 p173-205
- Human Embryology, Fitzgerald and Fitzgerald Chapter 21-22 p134-152
- Developmental Biology (6th ed.) Gilbert Chapter 14 Intermediate Mesoderm
Mouse Prostate
Androgenic regulation of ventral epithelial bud number and pattern in mouse urogenital sinus.[2]
- begins in fetal mice ductal progenitors (or buds) emerge from urogenital sinus epithelium
- prostatic buds develop in response to androgens, which activate androgen receptors in UGS mesenchyme
- two rows of 3-4 prostatic buds at birth
Movies
Genital development animations
Urogenital Sinus | Urogenital Septum |
Male External | Testis Descent |
Development Overview
Three main stages during development, mesonephric/paramesonephric duct changes are one of the first male/female differences that occur in development, while external genitaila remain indeterminate in appearance for quite a while.
- Differentiation of gonad (Sex determination)
- Differentiation of internal genital organs
- Differentiation of external genital organs
The 2nd and 3rd stages dependent on endocrine gonad. Reproductive development has a long maturation timecourse, begining in the embryo and finishing in puberty. (More? Puberty Development)
Historic Images of Genital Changes
Urogenital indifferent | Urogenital male | Urogenital female |
Additional Images
Stages of primordial germ cell migration[3]
References
- ↑ <pubmed>19906863</pubmed>
- ↑ <pubmed>19941349</pubmed>
- ↑ <pubmed> 20027186</pubmed>| Nature Reviews Molecular Cell Biology
Reviews
Articles
Search PubMed
Search Pubmed: Male Genital System Development | mesonephric duct
Terms
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, June 1) Embryology Prostate Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Prostate_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G