Quicktime Movie - Blastocyst Development
width=500px|height=450px|controller=true|autoplay=false</qt> | Movie shows in vitro development of a human morula to blastocyst between day 3 and day 6 post-fertilization.
00:00 day 3 - Initially a solid mass of cells morula stage enclosed by the zona pellucida. 00:18 day 4 - blastocoel formation 00:22 - inner cell mass (embryoblast) 00:29 - maximal expansion of blastocyst in ZP 00:31 - contraction 00:32 - re-expansion 00:37 day 5 - contraction 00:38 - re-expansion 00:39 - contraction (collapse) 00:40 - re-expansion (blastocoel enlargement) 00:41 - commence blastocyst hatching (1 o'clock position) 00:44 - complete hatching, blastocyst expansion (inner cell mass 2 o'clock position) 00:47 - trophoblast layer thickens 00:53 day 6 - movie finishes
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Reference
<pubmed>20890283</pubmed>| Nat Biotechnol.
Reprinted by permission from Macmillan Publishers Ltd: Nat Biotechnol. (Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Wong CC, Loewke KE, Bossert NL, Behr B, De Jonge CJ, Baer TM, Pera RA. Nat Biotechnol. 2010 Oct 3. [Epub ahead of print] PMID: 20890283), copyright (2010)