File:Neural - Human hippocampus marker expression.jpg

Human hippocampus marker expression

Summary of marker expression in the human hippocampus related to the milestones of adult hippocampal neurogenesis in rodents.

The frame indicates the stages of adult neurogenesis covered in this study: all additional markers were tested together with DCX.

Marker combinations that we could detect in our samples are marked with a green check.

Not all markers were found at all ages, see paper Figs. 6 for details.

Original File Name: Figure 10. Journal.pone.0008809.g010.jpg http://www.plosone.org/article/slideshow.action?uri=info:doi/10.1371/journal.pone.0008809&imageURI=info:doi/10.1371/journal.pone.0008809.g010

"Our data suggest that in the adult human hippocampus neurogenesis-associated features that have been identified in rodents show patterns, as well as qualitative and quantitative age-related changes, that are similar to the course of adult hippocampal neurogenesis in rodents. Consequently, although further validation as well as the application of independent methodology (e.g. electron microscopy and cell culture work) is desirable, our data will help to devise the framework for specific research on cellular plasticity in the aging human hippocampus."

Reference

<pubmed>20126454</pubmed>| PLoS One.

Copyright: © 2010 Knoth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.