Talk:Organoids

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On this website the Discussion Tab or "talk pages" for a topic has been used for several purposes: References - recent and historic that relates to the topic Additional topic information - currently prepared in draft format Links - to related webpages Topic page - an edit history as used on other Wiki sites Lecture/Practical - student feedback Student Projects - online project discussions. Links: Pubmed Most Recent | Reference Tutorial | Journal Searches Glossary Links Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link Cite this page: Hill, M.A. (2026, October 4) Embryology Organoids. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Organoids

2017

The use of brain organoids to investigate neural development and disease

Nat Rev Neurosci. 2017 Oct;18(10):573-584. doi: 10.1038/nrn.2017.107. Epub 2017 Sep 7.

Di Lullo E1,2, Kriegstein AR1,2.

Understanding the development and dysfunction of the human brain is a major goal of neurobiology. Much of our current understanding of human brain development has been derived from the examination of post-mortem and pathological specimens, bolstered by observations of developing non-human primates and experimental studies focused largely on mouse models. However, these tissue specimens and model systems cannot fully capture the unique and dynamic features of human brain development. Recent advances in stem cell technologies that enable the generation of human brain organoids from pluripotent stem cells (PSCs) promise to profoundly change our understanding of the development of the human brain and enable a detailed study of the pathogenesis of inherited and acquired brain diseases. PMID: 28878372 PMCID: PMC5667942 DOI: 10.1038/nrn.2017.107

Kidney Organoids: A Translational Journey

Trends Mol Med. 2017 Mar;23(3):246-263. doi: 10.1016/j.molmed.2017.01.001. Epub 2017 Feb 7.

Morizane R1, Bonventre JV2.

Human pluripotent stem cells (hPSCs) are attractive sources for regenerative medicine and disease modeling in vitro. Directed hPSC differentiation approaches have derived from knowledge of cell development in vivo rather than from stochastic cell differentiation. Moreover, there has been great success in the generation of 3D organ-buds termed 'organoids' from hPSCs; these consist of a variety of cell types in vitro that mimic organs in vivo. The organoid bears great potential in the study of human diseases in vitro, especially when combined with CRISPR/Cas9-based genome-editing. We summarize the current literature describing organoid studies with a special focus on kidney organoids, and discuss goals and future opportunities for organoid-based studies. Copyright © 2017 Elsevier Ltd. All rights reserved. PMID: 28188103 PMCID: PMC5442988 DOI: 10.1016/j.molmed.2017.01.001

2016

Modeling Development and Disease with Organoids

Cell. 2016 Jun 16;165(7):1586-1597. doi: 10.1016/j.cell.2016.05.082.

Clevers H1.

Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish." Additionally, patient-derived organoids hold promise to predict drug response in a personalized fashion. Organoids open up new avenues for regenerative medicine and, in combination with editing technology, for gene therapy. The many potential applications of this technology are only beginning to be explored. Copyright © 2016 Elsevier Inc. All rights reserved. PMID: 27315476 DOI: 10.1016/j.cell.2016.05.082