Talk:Abnormal Development - Air Pollution

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Cite this page: Hill, M.A. (2026, April 18) Embryology Abnormal Development - Air Pollution. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Abnormal_Development_-_Air_Pollution


2018

Air Pollution Exposure During Fetal Life, Brain Morphology, and Cognitive Function in School-Age Children

Biol Psychiatry. 2018 Aug 15;84(4):295-303. doi: 10.1016/j.biopsych.2018.01.016. Epub 2018 Jan 31.

Guxens M1, Lubczyńska MJ2, Muetzel RL3, Dalmau-Bueno A2, Jaddoe VWV4, Hoek G5, van der Lugt A6, Verhulst FC7, White T8, Brunekreef B9, Tiemeier H10, El Marroun H3.

Abstract BACKGROUND: Air pollution exposure during fetal life has been related to impaired child neurodevelopment, but it is unclear if brain structural alterations underlie this association. The authors assessed whether air pollution exposure during fetal life alters brain morphology and whether these alterations mediate the association between air pollution exposure during fetal life and cognitive function in school-age children. METHODS: We used data from a population-based birth cohort set up in Rotterdam, The Netherlands (2002-2006). Residential levels of air pollution during the entire fetal period were calculated using land-use regression models. Structural neuroimaging and cognitive function were performed at 6 to 10 years of age (n = 783). Models were adjusted for several socioeconomic and lifestyle characteristics. RESULTS: Mean fine particle levels were 20.2 μg/m3 (range, 16.8-28.1 μg/m3). Children exposed to higher particulate matter levels during fetal life had thinner cortex in several brain regions of both hemispheres (e.g., cerebral cortex of the precuneus region in the right hemisphere was 0.045 mm thinner (95% confidence interval, 0.028-0.062) for each 5-μg/m3 increase in fine particles). The reduced cerebral cortex in precuneus and rostral middle frontal regions partially mediated the association between exposure to fine particles and impaired inhibitory control. Air pollution exposure was not associated with global brain volumes. CONCLUSIONS: Exposure to fine particles during fetal life was related to child brain structural alterations of the cerebral cortex, and these alterations partially mediated the association between exposure to fine particles during fetal life and impaired child inhibitory control. Such cognitive impairment at early ages could have significant long-term consequences. Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. KEYWORDS: Child development; Cognition; Cohort studies; Environmental pollution; Neuroimaging; Particulate matter PMID: 29530279 DOI: 10.1016/j.biopsych.2018.01.016

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