File:Sea Urchin-endomesoderm induction.png

Gene Regulatory Networks Underlying Endomesoderm Induction

(A) The micromere determinant Pmar1 (circled in red) activates the PMC-GRN in micromere progeny and is sufficient for micromere-derived endomesoderm-inducing signals. The E-EM/En-GRNs (up to 17 h postfertilization) integrate the regulatory functions of maternal and zygotic core factors that drive the earliest steps of endomesoderm progenitor specification in sea urchin embryos. The zygotically expressed core factors Z13, Eve, Wnt8, Blimp1, FoxA, and Brachyury (Bra) (circled in black) accumulate in presumptive endomesoderm during early developmental stages and could potentially respond to early inductive inputs from micromere descendants.

(B) Schematic depicting an experiment that reveals micromere-derived endomesoderm inductive signals, which are sufficient to induce ectopic endo16 expression and complete archenteron formation in animal blastomeres, and are also necessary for normal vegetal endo16 expression and timely gastrulation in the sea urchin embryo. The regulatory interactions among these signals and the overall EM-GRN are unknown. GRN diagram is adapted from [8].

See also: myGRN myGRN: a database and visualisation system for the storage and analysis of developmental genetic regulatory networks http://www.ncbi.nlm.nih.gov/pubmed/19500400

Links: sea urchin | endoderm | mesoderm

Reference

Sethi AJ, Angerer RC & Angerer LM. (2009). Gene regulatory network interactions in sea urchin endomesoderm induction. PLoS Biol. , 7, e1000029. PMID: 19192949 DOI.

Copyright

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

doi:10.1371/journal.pbio.1000029.g001

Original file name: Journal.pbio.1000029.g001.png

Cite this page: Hill, M.A. (2024, June 20) Embryology Sea Urchin-endomesoderm induction.png. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Sea_Urchin-endomesoderm_induction.png

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