File:Mouse- gonadal supporting cell development.jpg

Somatic Sex Determination in Mice

Schematic diagram showing differentiation of gonadal supporting cells (green) into male Sertoli cells (blue) or female pre-granulosa cells (pink). Changes in gene expression driving supporting cell differentiation and the downstream sexual differentiation of other gonadal cell types are indicated.

• green - gonadal supporting cells
• blue - Sertoli cells (male)
• pink - pre-granulosa cells (female)

Reference

Kocer A, Reichmann J, Best D & Adams IR. (2009). Germ cell sex determination in mammals. Mol. Hum. Reprod. , 15, 205-13. PMID: 19218284 DOI.

Copyright

© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed: the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given: if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative word this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Citation: Germ cell sex determination in mammals. Kocer A, Reichmann J, Best D, Adams IR. Mol Hum Reprod. 2009 Apr;15(4):205-13. Epub 2009 Feb 13. Review.

Original File name: Figure 1 http://molehr.oxfordjournals.org/cgi/content/full/15/4/205/GAP008F1