Molecular Development of Endocrine Pancreas Cells
Model placing gastrin cells in the transcriptional hierarchy of endocrine cells in the pancreas.
Four main endocrine adult cell types:
- alpha cells secreting glucagon
- beta cells secreting insulin
- delta cells secreting somatostatin
- PP cells secreting pancreatic polypeptide.
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Pancreatic G cells
- similar to alpha cells in that it is dependent on Arx.
- similar to epsilon cells in that both gastrin and ghrelin are frequently co-expressed with glucagon in the embryonic pancreas.
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- Links: Endocrine ancreas | Pax | Molecular Development
| Factor Information
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- Pdx1 - Pancreas/Duodenum Homeobox Protein 1 OMIM 600733
- transcription (transactivator) factor binds the TAAT element in the promoter region of target genes, mainly those involved in pancreas development.
- Ngn3 - Neurogenin3 OMIM 604882
- basic helix-loop-helix transcription factor involved in the determination of neural precursor cells in the neuroectoderm.
- NeuroD1 - Neurogenic Differentiation 1 OMIM 601724
- a basic helix-loop-helix (bHLH) protein that acts as a transcription factors involved in determining cell type during development.
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- Arx - Aristaless-Related Homeobox, X-Linked OMIM 300382
- homeobox protein that belongs to the Aristaless-related subset of the paired (Prd) class of homeodomain proteins.
- Pax4 - Paired Box Gene 4 OMIM 167413
- transcription factor containing a paired box domain.
- Pax6 Paired Box Gene 6 OMIM 607108
- transcription factor containing a paired box domain.
- Nkx2.2 - NK2 Homeobox 2 OMIM 604612
- homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.
- Nkx6.1 - NK2 Homeobox 6.1 OMIM 602563
- homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.
- required for beta cells development and is completely conserved between rat, mouse, and human.
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References
<pubmed>23940571</pubmed>| PLoS One.
Copyright
© 2013 Suissa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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