Talk:Draft 2016

Lymph Nodes

Lymph Node Anatomy

Lymph Node Anatomy
Location throughout the entire body - concentrated in axilla, groin, lung, gastrointestinal tract mesenteries Small (1 mm - 2 cm) encapsulated organ (diffuse lymphoid tissue - no capsule) Antigen transformed lymphocytes from the blood In lymph vessel pathways “filter” lymph Afferent - towards node (A - arrives at the node) Efferent - away from node (E - exits the node) Mesenteric lymph nodes

Lymph Node Functions

Lymph Node Functions
In lymph vessel pathways “filter” (surveillance) lymph Immune - detect infections from peripheral tissues skin, respiratory tract, gastrointestinal tract, etc. secondary lymphoid organ return extracellular fluid to circulation

Lymph Node Structure

Lymph Node Structure
Simplified structure	Lymphocyte (T and B) Traffic Enter from high endothelial venules (HEVs also called post-capillary venules) Spend 8 to 24 h in the lymph node interstitium. Enter a network of medullary sinuses. Drain from sinuses into efferent lymphatic vessels.
	Lymph pathway Afferent vessel Subcapsular sinus Paratrabecular sinus Medullary sinus Efferent vessel Watch T and B Lymphocytes Move   ‎‎Lymph Node 7 Page | Play  ‎‎Lymph Node 8 Page | Play

Lymph Node Histology

Lymph Node Histology

Connective Tissue Capsule - dense connective tissue (irregular CT, some adipocytes)) Trabeculae - dense connective tissue Reticular Tissue - Reticular cells and fibers, supporting meshwork (collagen type III) Reticular cell produces reticular fibers (collagen type III) and surrounds the fibers with its cytoplasm reticular fibres can also be produced by fibroblasts Subcapsular Sinus Follicle Germinal Centre (marginal sinus, continuation of trabecular sinus) Medullary Cords and Sinuses High Endothelial Venues Macrophages Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development Links: Immunobiology - Figure 1.8. Organization of a lymph node