File:Cajal bodies PMID12379800.jpg
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Nucleus - Cajal Bodies
Located within the cell nucleus these bodies have also been called: nucleolar accessory bodies, coiled body, gems. Their size is about 0.1 - 2.0 microns, numbering about 1 to 10 in each nucleus. Proposed sites where small nuclear ribonucleoproteins (snRNPs) and small nucleolar RNAs (snoRNPs) are modified.
Ramón y Cajal first identified and christened them "nucleolar accessory bodies".[1]
(A) HeLa cells expressing an FP–coilin fusion protein (arrows indicate Cajal bodies).
(B) Fluorescence micrograph of purified CBs immunolabeled with anticoilin antibodies.
(C) Field emission scanning electron micrograph of a purified CB.
(D) Transmission electron micrograph of a purified CB. Coilin is immunolabeled with 5 nm gold (arrows) and SMN is immunolabeled with 10 nm gold (arrowheads).
Bars: (A and B) 10 μm; (C) 500 nm; (D) 200 nm.
SMN1 - (5q13) encodes a 38 kD protein located in Cajal bodies associated with Spinal muscular atrophy.
Fragile X protein (FMRP) isoforms 6 and 12 (ISO6 and 12) have been localized to the Cajal bodies in cultured human cells.[2]
Fragile X Syndrome (FXS) is the most common form of inherited mental retardation and autism.
- A - HeLa cells expressing an FP–coilin fusion protein (arrows indicate Cajal bodies).
- B - Fluorescence micrograph of purified CBs immunolabeled with anticoilin antibodies.
- C - Field emission scanning electron micrograph of a purified CB.
- D - Transmission electron micrograph of a purified CB. Coilin is immunolabeled with 5 nm gold (arrows) and SMN is immunolabeled with 10 nm gold (arrowheads).
Bars: (A and B) 10 μm; (C) 500 nm; (D) 200 nm.
(CB) Ramon y Cajal originally identified (1903) these small structures located in the cell nucleus. They have various suggested functions including ribonucleoprotein functions and RNA maturation. During the cell cycle they disassemble and reassemble, and are localized to the nucleolar periphery or within the nucleoli. The protein coilin is located within Cajal bodies.
- Links: Spinal muscular atrophy | Image - FMRP and Cahal bodies | Cajal | Fragile X Syndrome | Search PubMed
Reference
Ogg SC & Lamond AI. (2002). Cajal bodies and coilin--moving towards function. J. Cell Biol. , 159, 17-21. PMID: 12379800 DOI.
- ↑ Gall JG. (2003). The centennial of the Cajal body. Nat. Rev. Mol. Cell Biol. , 4, 975-80. PMID: 14685175 DOI.
- ↑ Dury AY, El Fatimy R, Tremblay S, Rose TM, Côté J, De Koninck P & Khandjian EW. (2013). Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. PLoS Genet. , 9, e1003890. PMID: 24204304 DOI.
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